Zobrazeno 1 - 10
of 154
pro vyhledávání: '"Xueyi Dong"'
Autor:
Yue You, Xueyi Dong, Yong Kiat Wee, Mhairi J. Maxwell, Monther Alhamdoosh, Gordon K. Smyth, Peter F. Hickey, Matthew E. Ritchie, Charity W. Law
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-21 (2023)
Abstract Group heteroscedasticity is commonly observed in pseudo-bulk single-cell RNA-seq datasets and its presence can hamper the detection of differentially expressed genes. Since most bulk RNA-seq methods assume equal group variances, we introduce
Externí odkaz:
https://doaj.org/article/d10773884bdb4c46881828200216a0c4
Autor:
Nan Zhao, Chunsheng Ni, Shuai Fan, Na Che, Yanlei Li, Song Wang, Yongli Li, Xueyi Dong, Yuhong Guo, Xiulan Zhao, Tieju Liu
Publikováno v:
Cancers, Vol 16, Iss 1, p 15 (2023)
Triple-negative breast cancer (TNBC) has a shorter survival time and higher mortality rate than other molecular subtypes. RSRC2 is a newly discovered tumor suppressor gene. However, the potential functional mechanism of RSRC2 in TNBC remains unknown
Externí odkaz:
https://doaj.org/article/403b893560614c1db916c1b390fa1329
Autor:
Huizhi Sun, Jing Mo, Runfen Cheng, Fan Li, Yue Li, Yuhong Guo, Yanlei Li, Yanhui Zhang, Xiaoyu Bai, Yalei Wang, Xueyi Dong, Danfang Zhang, Jihui Hao
Publikováno v:
Cancer Biology & Medicine, Vol 19, Iss 11, Pp 1598-1616 (2022)
Objective: Hypoxia is an important feature of pancreatic ductal adenocarcinoma (PDAC). Previously, we found that hypoxia promotes ENO1 expression and PDAC invasion. However, the underlying molecular mechanism was remains unclear. Methods: The relatio
Externí odkaz:
https://doaj.org/article/353761a4dd4048a1b59236abeed331ee
Autor:
Huizhi Sun, Yanlei Li, Yanhui Zhang, Xiulan Zhao, Xueyi Dong, Yuhong Guo, Jing Mo, Na Che, Xinchao Ban, Fan Li, Xiaoyu Bai, Yue Li, Jihui Hao, Danfang Zhang
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
IntroductionHypoxia is an important characteristic of solid tumors. However, spatial transcriptomics (ST) of hypoxia-associated heterogeneity is not clear.MethodsThis study integrated Spatial Transcriptomics (ST) with immunofluorescence to demonstrat
Externí odkaz:
https://doaj.org/article/c3b25f10ed784398a6b4b85d3dd20e1d
Autor:
Nan Zhao, Yanhui Zhang, Runfen Cheng, Danfang Zhang, Fan Li, Yuhong Guo, Zhiqiang Qiu, Xueyi Dong, Xinchao Ban, Baocun Sun, Xiulan Zhao
Publikováno v:
Cancer Cell International, Vol 22, Iss 1, Pp 1-18 (2022)
Abstract Background Hepatocellular carcinoma (HCC) often presents with satellite nodules, rendering current curative treatments ineffective in many patients. The heterogeneity of HCC is a major challenge in personalized medicine. The emergence of spa
Externí odkaz:
https://doaj.org/article/327e4d53d57f42e8baf85e057bdc95ec
Autor:
Fan Li, Huizhi Sun, Yue Li, Xiaoyu Bai, Xueyi Dong, Nan Zhao, Jie Meng, Baocun Sun, Danfang Zhang
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-20 (2021)
Abstract Background The expression and activation of eukaryotic translation initiation factor 4E (eIF4E) is associated with cell transformation and tumor initiation, but the functional role and the mechanism whereby it drives immune cell infiltration
Externí odkaz:
https://doaj.org/article/027c2e73ae684ee8b3648a02d0b6e99a
Autor:
Yue You, Luyi Tian, Shian Su, Xueyi Dong, Jafar S. Jabbari, Peter F. Hickey, Matthew E. Ritchie
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-32 (2021)
Abstract Background Single-cell RNA-sequencing (scRNA-seq) technologies and associated analysis methods have rapidly developed in recent years. This includes preprocessing methods, which assign sequencing reads to genes to create count matrices for d
Externí odkaz:
https://doaj.org/article/52b16953cfe04fc5a8828e3325d5735b
Autor:
Luyi Tian, Jafar S. Jabbari, Rachel Thijssen, Quentin Gouil, Shanika L. Amarasinghe, Oliver Voogd, Hasaru Kariyawasam, Mei R. M. Du, Jakob Schuster, Changqing Wang, Shian Su, Xueyi Dong, Charity W. Law, Alexis Lucattini, Yair David Joseph Prawer, Coralina Collar-Fernández, Jin D. Chung, Timur Naim, Audrey Chan, Chi Hai Ly, Gordon S. Lynch, James G. Ryall, Casey J. A. Anttila, Hongke Peng, Mary Ann Anderson, Christoffer Flensburg, Ian Majewski, Andrew W. Roberts, David C. S. Huang, Michael B. Clark, Matthew E. Ritchie
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-24 (2021)
Abstract A modified Chromium 10x droplet-based protocol that subsamples cells for both short-read and long-read (nanopore) sequencing together with a new computational pipeline (FLAMES) is developed to enable isoform discovery, splicing analysis, and
Externí odkaz:
https://doaj.org/article/b1aa5d4188e746cca4e60723f7229ae1
Autor:
Yue You, Xueyi Dong, Yong Kiat Wee, Mhairi J. Maxwell, Monther Alhamdoosh, Gordon K. Smyth, Peter F. Hickey, Matthew E. Ritchie, Charity W. Law
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/069db538e8c34bdfb20f76f929315fd0
Autor:
Huizhi Sun, Danfang Zhang, Chongbiao Huang, Yuhong Guo, Zhao Yang, Nan Yao, Xueyi Dong, Runfen Cheng, Nan Zhao, Jie Meng, Baocun Sun, Jihui Hao
Publikováno v:
Cancer Biology & Medicine, Vol 18, Iss 2, Pp 616-630 (2021)
Objective: Hypoxia is a significant feature of solid tumors, including pancreatic ductal adenocarcinoma (PDAC). It is associated with tumor invasion, metastasis, and drug resistance. However, the spatial distribution of hypoxia-related heterogeneity
Externí odkaz:
https://doaj.org/article/ed1ddd0f573e437d87dea544786c4cfc