Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Xueyang Jiang"'
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 10, Iss 2, Pp 207-238 (2020)
Blocking the biological functions of scaffold proteins and aggregated proteins is a challenging goal. PROTAC proteolysis-targeting chimaera (PROTAC) technology may be the solution, considering its ability to selectively degrade target proteins. Recen
Externí odkaz:
https://doaj.org/article/bcabdc2eb59e4a3faa27a5bb8131d408
Autor:
Yao Chen, Jie Zhu, Jun Mo, Hongyu Yang, Xueyang Jiang, Hongzhi Lin, Kai Gu, Yuqiong Pei, Liang Wu, Renxiang Tan, Jing Hou, Jingyi Chen, Yang Lv, Yaoyao Bian, Haopeng Sun
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 290-302 (2018)
Small molecule cholinesterases inhibitor (ChEI) provides an effective therapeutic strategy to treat Alzheimer’s disease (AD). Currently, the discovery of new ChEI with multi-target effect is still of great importance. Herein, we report the synthesi
Externí odkaz:
https://doaj.org/article/245b93a03cc84762bfc4b70874b4d80a
Autor:
Hongzhi Lin, Qihang Li, Qi Li, Jie Zhu, Kai Gu, Xueyang Jiang, Qianqian Hu, Feng Feng, Wei Qu, Yao Chen, Haopeng Sun
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 777-793 (2018)
Histone demethylation is a vital process in epigenetic regulation of gene expression. A number of histone demethylases are present to control the methylated states of histone. Among these enzymes, KDM4s are one subfamily of JmjC KDMs and play importa
Externí odkaz:
https://doaj.org/article/cb64bc416d7349de9d190406a383f058
Publikováno v:
Molecules, Vol 23, Iss 7, p 1715 (2018)
A facile one-pot synthetic method of building aryloxyalkyl esters was developed using various types of phenolic esters with halogenated alcohols. The ready availability of both starting materials, coupled with the required simple experimental techniq
Externí odkaz:
https://doaj.org/article/1ffaaa0df0f648f9b53a4369561b65f9
Autor:
Feng Feng, Wenyuan Liu, Jian Xu, Yun-Wei Hu, Wan-Qi Xu, Yu-Ying Wang, Ying Liu, Xueyang Jiang, Yan Gao, Er-Yan Guo
Publikováno v:
Journal of Natural Products. 84:1889-1897
Chemotherapy resistance is one of the main causes of lung cancer treatment failure, and a combination regimen may be an effective way to overcome this. Here we report 5 new (1-3, 7, and 9) and 15 known polyketides, isolated from an endozoic Aspergill
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::675f98c729ef3e92db08629592449b47
https://doi.org/10.1021/acs.jnatprod.0c01262
https://doi.org/10.1021/acs.jnatprod.0c01262
Autor:
Hongwei Wang, Enjing Cui, Jiaming Li, Xiaodong Ma, Xueyang Jiang, Shuaishuai Du, Shihu Qian, Le Du
Publikováno v:
European journal of medicinal chemistry. 241
Microglia-mediated neuroinflammation plays an important role in ischemic stroke (IS). In this work, a series of novel indole and indazole-piperazine pyrimidine derivatives with anti-neuroinflammatory and neuroprotective activities were designed and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65610cc8ebefcc3b645004d1a646eace
https://pubmed.ncbi.nlm.nih.gov/35931005
https://pubmed.ncbi.nlm.nih.gov/35931005
Autor:
Xueyang Jiang, Junting Zhou, Hongli Jiang, Haopeng Sun, Siyu He, Wenyuan Liu, Feng Feng, Wei Qu
Publikováno v:
Journal of Medicinal Chemistry. 62:8881-8914
Due to the complexity of multifactorial diseases, single-target drugs do not always exhibit satisfactory efficacy. Recently, increasing evidence indicates that simultaneous modulation of multiple targets may improve both therapeutic safety and effica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e60c516d9299b8a635bfbfaa6dded8e
https://doi.org/10.1021/acs.jmedchem.9b00017
https://doi.org/10.1021/acs.jmedchem.9b00017
Autor:
Xiaoxia Zhu, Xueyang Jiang, Feng Feng, Jian Xu, Xin Lv, Yunwei Hu, Zhaoxia Shi, Ying Liu, Yuanyuan Yu
Publikováno v:
Chemistry & Biodiversity. 18
One new dioxolanone derivative, guignardianone G (1) and twelve known compounds (2-13) were isolated from the 95 % ethanol extract of the plant endophytic fungus Phyllosticta capitalensis cultured in rice medium. Among these known compounds, isoalten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bf4273617198bbce3cb7e2521a717dd
https://doi.org/10.1002/cbdv.202100314
https://doi.org/10.1002/cbdv.202100314
Autor:
Feng Feng, Wenyuan Liu, Haopeng Sun, Yao Chen, Xin Lu, Hongyu Yang, Yijun Liu, Nan Qin, Yuting Qiao, You Zhou, Xueyang Jiang
Publikováno v:
Future medicinal chemistry. 13(13)
Background: Alzheimer's disease is a multifactorial neurological disorder seen in elderly people. Loss of cholinergic transmission and unbalanced tryptophan metabolism kynurenine pathway have been demonstrated in neuropsychiatric diseases. Methods &
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16c3aba134cdbfceb7aa8ca2751b55d3
https://pubmed.ncbi.nlm.nih.gov/33960203
https://pubmed.ncbi.nlm.nih.gov/33960203
Autor:
Qianqian, Zhang, Xi, Zhang, Pengpeng, Duan, Xueyang, Jiang, Haojie, Shen, Xiaoyuan, Yan, Zhengqin, Xiong
Publikováno v:
The Science of the total environment. 769
Numerous studies reporting a transient decrease in soil nitrous oxide (N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::522c472bf124f4dd1a806d9456b82712
https://pubmed.ncbi.nlm.nih.gov/33482542
https://pubmed.ncbi.nlm.nih.gov/33482542