1,3-Benzodioxole-Modified Noscapine Analogues: Synthesis, Antiproliferative Activity, and Tubulin-Bound Structure

Autor: Andrea E. Prota, Stefan D. Tomlins, Xuexin Gao, Cassandra Yong, Anne-Catherine Abel, Peter J. Scammells, Shane M. Devine, Michel O. Steinmetz, Ben Capuano, Richard Callaghan, Divya Muthiah

Publikováno v: ChemMedChem. 16(18)

Since the revelation of noscapine's weak anti-mitotic activity, extensive research has been conducted over the past two decades, with the goal of discovering noscapine derivatives with improved potency. To date, noscapine has been explored at the 1,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7004ca1037939e5650a0ec57bf074897
https://pubmed.ncbi.nlm.nih.gov/34159741

New Evidence for P-gp-Mediated Export of Amyloid-β Peptides in Molecular, Blood-Brain Barrier and Neuronal Models

Autor: Amanda B. Chai, Xuexin Gao, Anika M.S. Hartz, Richard Callaghan, Ingrid C. Gelissen, Alryel Yang

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 246, p 246 (2021)
Volume 22
Issue 1

Defective clearance mechanisms lead to the accumulation of amyloid-beta (A&beta
) peptides in the Alzheimer&rsquo
s brain. Though predominantly generated in neurons, little is known about how these hydrophobic, aggregation-prone, and tightl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::858e5f3d560af313a8fda830e03164ed
http://europepmc.org/articles/PMC7795149

Research of Reuse Technology of Test Case Based on Function Calling Path

Autor: Yongmin Mu, Meie Shen, Xuexin Gao

Publikováno v: Chinese Journal of Electronics. 27:768-775

In the process of software testing, it requires a lot of manpower and time to design test cases. Test cases of high similarities can be modified to reduce the workload of test case design, and improve the test efficiency. A test case reuse method bas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::224475a1d47917c635451ec0cd8c5732
https://doi.org/10.1049/cje.2018.04.012

Community delivery of semiautomated fractal analysis tool in cardiac mr for trabecular phenotyping

Autor: Catalina Tobon-Gomez, Dina Radenkovic, David A. Bluemke, Matthias G. Friedrich, Nay Aung, James C. Moon, Steffen E. Petersen, Xuexin Gao, Yu Liu, Perry M. Elliott, Filip Zemrak, Chunming Li, Gabriella Captur

Publikováno v: Journal of Magnetic Resonance Imaging. 46:1082-1088

Contract grant sponsor: UK National Institute for Health Research Rare Diseases Translational Research Collaboration; contract grant number: NIHR RD-TRC, 171603; Contract grant sponsor: NIHR University College London Hospitals Biomedical Research Cen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::33e9ac11ece6197cbc80f4989c9e938e
https://doi.org/10.1002/jmri.25644

MODERATED EPOSTERS1385Longitudinal strain assessment in dilated cardiomyopathy patients using a novel accelerated DENSE sequence1407Simultaneous T1 and T2 cardiac quantification with CABIRIA: initial clinical experience1423Head-to-head comparison of acceleration algorithms in 4-dimensional flow CMR1502Left ventricular function and size evaluated by hybrid cardiac positron emission tomography-magnetic resonance: Intraindividual comparison of left ventricular ejection fraction and ventricular volumes derived by two modalities1510Left Atrium assessed by Cardiovascular Magnetic Resonance at 1.5 and 3 Tesla – age and gender effects1514Comparison of Free Breathing Cardiac MRI Radial technique to the Standard Multi breath-hold cine SSFP CMR technique for the assessment of LV Volumes and Function1536Self-navigated free-breathing isotropic 3D whole heart phase sensitive inversion recovery magnetic resonance without navigator for detection of myocardial infarction1547Assessment of Right Ventricular Strain Using Myocardial Deformation Recovery Semi Automated Technique: Initial Experience and Normal Values1586Tissue tracking myocardial deformation analysis and prediction of left ventricular remodeling in acute myocardial infarction1589Investigating strategies for optimal 31P MRS clinical cardiac at 3T: Initial Results1620Quantitative Criteria for the Diagnosis of the Congenital Absence of Pericardium by Cardiac Magnetic Resonance1632Widespread tissue injury during acute myocardial infarction: evidence from advanced CMR relaxometry1322Computed tomography coronary angiography verSus sTRess cArdiac magneTic rEsonance for the manaGement of sYmptomatic revascularized patients: a cost effectiveness study (STRATEGY study)1339Comparison of low- versus high-dose of gadobutrol for late gadolinium enhancement imaging at 1.5 Tesla: a clinical feasibility study1347Multi-parametric Cardiac Magnetic Resonance for Prediction of Cardiac Complications in Thalassemia Intermedia: a Prospective Multicenter Study1461Prognostic value of Cardiovascular Magnetic Resonance derived indexes of myocardial fibrosis in heart transplant recipients1523The role of CMR in the acute phase of hospitalization: changing paradigms1542Preoperative CMR-based score predict ventricular response after surgical left ventricular reconstruction in ischemic heart failure patients1555Excellent response rate to cardiac resynchronization therapy guided with magnetic resonance imaging1626The ECG as a predictor of arrhythmogenic substrate on Cardiac Magnetic Resonance Imaging in patients undergoing ablation for premature ventricular contractions1649Comparison of T1-mapping at 3.0T CMR and angiographic APPROACH score for area at risk assessment in ST-segment elevation myocardial infarction1340Pathological correlates of left bundle branch disease in patients with non-ischemic cardiomyopathy: a cardiovascular magnetic resonance study1342Myocardial remodelling and fibrosis in nonischaemic dilated cardiomyopathy: insights from cardiovascular magnetic resonance1411The association between fibrosis and contractile dysfunction in hypertrophic cardiomyopathy assessed by cardiovascular magnetic resonance1622Persistent myocardial inflammation due to intramyocardial haemorrhage in reperfused STEMI as a precursor to adverse LV remodelling - insights from multi-parametric mapping1566Semiquantitative analysis of low and high b value DWI for detecting myocardial edema in acute myocarditis1567Value of Cardiac MRI In Detecting Coronary Artery Disease In Newly Diagnosed Systolic Dysfunction1570Usefulness of cardiac magnetic resonance in tuberous sclerosis complex1578Papillary muscles offer further insight into hypertrophied hearts: a cardiovascular magnetic resonance study1627Diagnostic and clinical implications of CMR timing (early versus late) in patients with troponin positive acute coronary syndromes and unobstructed coronary arteries: Table 1

Autor: Amardeep Ghosh Dastidar, Rebecca Kozor, Zorba Blázquez Bermejo, L.M. Desroche, J. Broncano, Heerajnarain Bulluck, Peter P Swoboda, A Barison, Chrysanthos Grigoratos, Sheraz A. Nazir, S. Oebel, R. Kockova, Giulia Careri, Estefania De Garate, Patrizia Pedrotti, Antonella Meloni, Gianluca Pontone, F. Macaione, R. Murdoch, F. Valente, Komal S Safdar, Tobias Rutz, Shimon Kolker, Stephanie Funk, D. Beitzke, P. Garg, Alexandros Kallifatidis, Upasana Tayal, Andrew D Scott, Rick Wage, Pedro Ferreira, Dudley Pennell, Xiaodong Zhong, Fred Epstein, David Firmin, Sanjay Prasad, Anastasios Prousalis, Sophia-Anastasia Mouratoglou, George Giannakoulas, Xenia Deligianni, Michail Bakaloudis, Nikolaos Magganaris, George Sianos, Haralampos Karvounis, Francesco Santini, R. Aziz, J.R.J. Foley, G. Fent, T.A. Musa, P. Haaf, L. Dobson, P.P. Swoboda, J.P. Greenwood, S. Plein, R.J.V.D. Geest, J.J.M. Westenberg, S. Rasul, W. Wadsak, M. Mitterhauser, R. Nolz, M. Stelzmueller, C. Loewe, M. Hacker, Josephine Kermer, Serkan Dogangüzel, Florian von Knobelsdorff-Brenkenhoff, Jeanette Schulz-Menger, Giora Weisz, Naama Bogot, Irit Hadas Halpern, Arik Wolak, Giulia Ginami, Davide Piccini, Simone Coppo, Gabriella Vincenti, Matthias Stuber, Jürg Schwitter, Xuexin Gao, Stephanie Ambach, Michal D Taylor, Ryan Moore, Robin J Taylor, Olga Toro-Salazar, John L Jeffries, Cheryl Bartone, Subha V Raman, Wojciech Mazur, J.F. Rodriguez-Palomares, L. Gutierrez, V. Pineda, B. Agliano, L. Galian, G. Teixido, M.T. Gonzalez-Alujas, A. Evangelista, D. Garcia-Dorado, S. Gandy, R. Nicholas, G. Houston, P. Martin, J. Muir, S. Matthew, P. Guntur- Ramkumar, I. Cavin, A. Barison, I. Pescetelli, F. Pali, F. Pizzino, A. Terrizzi, D. Di Lisi, G. Novo, G. Todiere, P. Assennato, S. Novo, G.D. Aquaro, Elisa McAlindon, Jonathan Rodrigues, Anna Baritussio, Alessandra Scatteia, Chris Benny Lawton, Tamas Erdei, Gergely Szantho, Mark Hamilton, Chiara Bucciarelli-Ducci, Daniele Andreini, Cristina Rota, Marco Guglielmo, Saima Mushtaq, Andrea Baggiano, Virginia Beltrama, Anna Solbiati, Andrea I. Guaricci, Mauro Pepi, Konstantinos Bratis, Markus Henningson, Matteo Dell'Omodarme, Valentina O. Puntmann, Eike Nagel, Nicola Giunta, Pietro Giuliano, Maria Giovanna Neri, Gennaro Restaino, Stefania Renne, Alessandra Quota, Vincenzo Positano, Daniele De Marchi, Alessia Pepe, Paola Campadello, Gabriella Masciocco, Rita Facchetti, Angela Milazzo, Giuseppina Quattrocchi, Cristina Giannattasio, Maria Frigerio, Alberto Roghi, Ornella Rimoldi, Antonio Amadu, Giuseppe Venuti, Jonathan C. Rodrigues, Serenella Castelvecchio, Antonia Camporeale, Francesco Secchi, Lorenzo Menicanti, Massimo Lombardi, K. Sedlacek, D. Wichterle, V. Sikula, J. Tintera, L. Sukupova, D. Kautznerova, M. Segetova, A. Praveckova, R. Langova, L. Kryze, W. El-Husseini, J. Kautzner, B. Dinov, A. Arya, S. Hilbert, P. Sommer, A. Bollmann, G. Hindricks, I. Paetsch, C. Jahnke, John P. Greenwood, Abhishek Shetye, Jamal N. Khan, Anvesha Singh, Prathap Kanagala, Daniel Swarbrick, Gaurav Gulsin, Matthew Graham-Brown, Anthony Gershlick, Gerry P. McCann, Riccardo Liga, Elena Bennatti, Andrea Barison, Giancarlo Todiere, Giovanni Donato Aquaro, Michele Emdin, Pier Giorgio Masci, A Ortalda, G Todiere, C Grigoratos, G Vergaro, G Mirizzi, N Martini, D De Marchi, P Keilberg, C Passino, GD Aquaro, M Emdin, Adam K McDiarmid, Bara Erhayiem, Graham J Fent, Laura E Dobson, Pankaj Garg, Tarique A Musa, James R Foley, Stephen P Page, John P Greenwood, Sven Plein, Stefania Rosmini, Amna Abdel-Gadir, Anish Bhuva, Thomas A Treibel, Steven K White, Marianna Fontana, Manish Ramlall, Ashraf Hamarneh, Alex Sirker, Anna Herrey, Charlotte Manisty, Derek M Yellon, Peter Kellman, James C Moon, Derek J Hausenloy, A. Luna, T. Martin – Noguerol, P. Caro, R. Toro-Cebada, J. Sanchez – Gonzalez, O. Milleron, B. Safar, Y. Lavie-Badie, D. Millischer, J. Abtan, G. Jondeau, Emilio Cuesta, Sandra O. Rosillo, Gabriela Guzmán, Inmaculada Pinilla, Óscar González, Juan Caro, Inés Ponz, Teresa López, Elena Refoyo, Sabrina Nordin, Silvia Castelleti, Gabriella Captur, Rick Steeds, Shanat Baig, Stuart M Grieve, Gemma A Figtree, Priyanka Singhal, Julian Strange, Angus Nightingale, Andreas Baumbach, Tom Johnson, Victoria Delgado

Publikováno v: European Heart Journal – Cardiovascular Imaging. 17:i24-i36

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fbb8ef44308e8dd4194d7636c1d92010
https://doi.org/10.1093/ehjci/jew182