Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Xuesen Hu"'
Autor:
Tianrun Xu, Hang Li, Peng Dou, Yuanyuan Luo, Siming Pu, Hua Mu, Zhihao Zhang, Disheng Feng, Xuesen Hu, Ting Wang, Guang Tan, Chuang Chen, Haiyang Li, Xianzhe Shi, Chunxiu Hu, Guowang Xu
Publikováno v:
Advanced Science, Vol 11, Iss 16, Pp n/a-n/a (2024)
Abstract High‐coverage mass spectrometry analysis of single‐cell metabolomics remains challenging due to the extremely low abundance and wide polarity of metabolites and ultra‐small volume in single cells. Herein, a novel concentric hybrid ioni
Externí odkaz:
https://doaj.org/article/cc77e21d86594b7ab3b56ab3199c2bc7
Autor:
Tsz Cheung, Chong, Iris L K, Wong, Jiahua, Cui, Man Chun, Law, Xuezhen, Zhu, Xuesen, Hu, Jason W Y, Kan, Clare S W, Yan, Tak Hang, Chan, Larry M C, Chow
Publikováno v:
International journal of molecular sciences. 23(21)
Overexpression of breast cancer resistance transporter (BCRP/ABCG2) in cancers has been explained for the failure of chemotherapy in clinic. Inhibition of the transport activity of BCRP during chemotherapy should reverse multidrug resistance. In this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::37c1ff8947a2264dd2d4dfa61a2d7324
https://pubmed.ncbi.nlm.nih.gov/36362047
https://pubmed.ncbi.nlm.nih.gov/36362047
Publikováno v:
TrAC Trends in Analytical Chemistry. 157:116763
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::483e13861636c23d0fe14ede73cb003b
https://doi.org/10.1016/j.trac.2022.116763
https://doi.org/10.1016/j.trac.2022.116763
Autor:
Kwok-Ho Lui, Clara Hiu-Ling Hung, Yanjuan Gu, Wai Sum Lo, Xuesen Hu, Tik-Hung Tsoi, William Chi-Shing Tai, Xin Li, Wing Tak Wong, Shiying Li
Publikováno v:
Nanoscale Advances. 1:554-564
The acidic microenvironment of tumor tissues has been proven to be a major characteristic for differentiation from normal tissues, thereby providing a desirable target for both disease diagnosis and functional imaging. We herein introduce a way to en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a52eb69304d21f7effc856a9dea096a
https://doi.org/10.1039/c8na00190a
https://doi.org/10.1039/c8na00190a
Autor:
Kin-Fai Chan, Xuesen Hu, Man Chun Law, Tak Hang Chan, Larry M.C. Chow, Xuezhen Zhu, Aya M. Y. Lo, Iris L. K. Wong
Publikováno v:
Journal of Medicinal Chemistry. 61:9931-9951
A 300-member flavonoid dimer library of multidrug resistance-associated protein 1 (MRP1, ABCC1) modulators was rapidly assembled using “click chemistry”. Subsequent high-throughput screening has led to the discovery of highly potent (EC50 ranging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cec24452c3f44f63c9802b880f83955
https://doi.org/10.1021/acs.jmedchem.8b00834
https://doi.org/10.1021/acs.jmedchem.8b00834
Autor:
Tsz Cheung Chong, Iris L. K. Wong, Kin-Fai Chan, Xuezhen Zhu, Jiahua Cui, Larry M.C. Chow, Man Chun Law, Tak Hang Chan, Xuesen Hu
Publikováno v:
Journal of medicinal chemistry. 62(18)
The present work describes the syntheses of diverse triazole bridged flavonoid dimers and identifies potent, nontoxic, and highly selective BCRP inhibitors. A homodimer, Ac22(Az8)2, with m-methoxyc...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42028e016a19b53895555a1f5cf8f143
https://pubmed.ncbi.nlm.nih.gov/31465686
https://pubmed.ncbi.nlm.nih.gov/31465686
Autor:
Shiying, Li, Kwok-Ho, Lui, Tik-Hung, Tsoi, Wai-Sum, Lo, Xin, Li, Xuesen, Hu, William, Chi-Shing Tai, Clara, Hiu-Ling Hung, Yan-Juan, Gu, Wing-Tak, Wong
Publikováno v:
Nanoscale advances. 1(2)
The acidic microenvironment of tumor tissues has been proven to be a major characteristic for differentiation from normal tissues, thereby providing a desirable target for both disease diagnosis and functional imaging. We herein introduce a way to en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::29f7575d3bb0e59a685c086da57817e8
https://pubmed.ncbi.nlm.nih.gov/36132235
https://pubmed.ncbi.nlm.nih.gov/36132235
Autor:
Zhang Xiao Yu, Tao Jiang, Xuesen Hu, Wan Sheng Biao, Iris L. K. Wong, Larry M.C. Chow, Li Fu Xing, Jin Wen Bin
Publikováno v:
Journal of Medicinal Chemistry. 56:9057-9070
A novel series of permethyl ningalin B analogues were synthesized and evaluated for their P-glycoprotein (P-gp)-modulating activities in a P-gp-overexpressing breast cancer cell line (LCC6MDR). Compounds 35 and 37, which possess one methoxy group and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2c32f9356bf8a722199cc788194730e
https://doi.org/10.1021/jm400930e
https://doi.org/10.1021/jm400930e
Publikováno v:
Archiv der Pharmazie. 344:71-77
This experiment was designed to synthesize 18 kinds of polyhydroxybenzophenones by using Friedel-Crafts reaction, and to measure the inhibitory activity on α-glucosidase with p-nitrophenyl-β-D-galactopyranoside (PNPG) as a substrate. Here, acarbose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b81fb25b99c1419865a397674f4816d5
https://doi.org/10.1002/ardp.201000147
https://doi.org/10.1002/ardp.201000147
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry. 26:449-452
A series of polyhydroxy benzophenone were synthesized and evaluated as mushroom tyrosinase inhibitors. The results demonstrated that most of the target compounds had remarkable inhibitory activities on mushroom tyrosinase. Among all these compounds,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecb242b4cfbb6791512f778eab6e47f1
https://doi.org/10.3109/14756366.2010.521745
https://doi.org/10.3109/14756366.2010.521745