Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Xueqiu Lin"'
Autor:
Leiping Zeng, Yanxia Liu, Xammy Huu Nguyenla, Timothy R. Abbott, Mengting Han, Yanyu Zhu, Augustine Chemparathy, Xueqiu Lin, Xinyi Chen, Haifeng Wang, Draven A. Rane, Jordan M. Spatz, Saket Jain, Arjun Rustagi, Benjamin Pinsky, Adrianna E. Zepeda, Anastasia P. Kadina, John A. Walker, Kevin Holden, Nigel Temperton, Jennifer R. Cochran, Annelise E. Barron, Michael D. Connolly, Catherine A. Blish, David B. Lewis, Sarah A. Stanley, Marie F. La Russa, Lei S. Qi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
A major challenge in coronavirus vaccination and treatment is to counteract rapid viral evolution and mutations. Here the authors show that CRISPR-Cas13d can be used as a broad-spectrum antiviral to inhibit human coronaviruses, including new SARS-CoV
Externí odkaz:
https://doaj.org/article/b19524c1f85b4105af7741efdca8ff41
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-13 (2020)
Abstract Genome-wide pooled CRISPR-Cas-mediated knockout, activation, and repression screens are powerful tools for functional genomic investigations. Despite their increasing importance, there is currently little guidance on how to design and analyz
Externí odkaz:
https://doaj.org/article/83f327fae159409aba8562bc507f9781
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 4, Pp 100245- (2021)
Summary: The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) and variants has led to significant mortality. We recently reported that an RNA-targeting CRISPR-Cas13 system, called pro
Externí odkaz:
https://doaj.org/article/f7fd26593e5e4550b3e9ebda34ee2d1a
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-13 (2018)
Abstract Pooled CRISPR screens allow researchers to interrogate genetic causes of complex phenotypes at the genome-wide scale and promise higher specificity and sensitivity compared to competing technologies. Unfortunately, two problems exist, partic
Externí odkaz:
https://doaj.org/article/cfe3404772dd4881b5deb3b9c5c449ba
Autor:
Jianzhong Su, Yung-Hsin Huang, Xiaodong Cui, Xinyu Wang, Xiaotian Zhang, Yong Lei, Jianfeng Xu, Xueqiu Lin, Kaifu Chen, Jie Lv, Margaret A. Goodell, Wei Li
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-12 (2018)
Abstract Background Cancers have long been recognized to be not only genetically but also epigenetically distinct from their tissues of origin. Although genetic alterations underlying oncogene upregulation have been well studied, to what extent epige
Externí odkaz:
https://doaj.org/article/ee2290fc8e834289a57ea339e90d7744
Autor:
Tianpeng Gu, Xueqiu Lin, Sean M. Cullen, Min Luo, Mira Jeong, Marcos Estecio, Jianjun Shen, Swanand Hardikar, Deqiang Sun, Jianzhong Su, Danielle Rux, Anna Guzman, Minjung Lee, Lei Stanley Qi, Jia-Jia Chen, Michael Kyba, Yun Huang, Taiping Chen, Wei Li, Margaret A. Goodell
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-15 (2018)
Abstract Background DNA methylation is a heritable epigenetic mark, enabling stable but reversible gene repression. In mammalian cells, DNA methyltransferases (DNMTs) are responsible for modifying cytosine to 5-methylcytosine (5mC), which can be furt
Externí odkaz:
https://doaj.org/article/6fd2d3e46453433ea4d4e102f933e748
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-10 (2017)
Abstract Background Whole-genome bisulfite sequencing (WGBS) is the gold standard for studying landscape DNA methylation. Current computational methods for WGBS are mainly designed for gene regulatory regions with multiple under-methylated CpGs (UMCs
Externí odkaz:
https://doaj.org/article/16523061bec345eebbd6d305ab48651d
Autor:
Xueqiu Lin1, Yanxia Liu1, Shuai Liu2, Xiang Zhu3,4,5, Lingling Wu1, Yanyu Zhu1, Dehua Zhao1, Xiaoshu Xu1, Chemparathy, Augustine6, Haifeng Wang1, Yaqiang Cao2, Muneaki Nakamura1, Noordermeer, Jasprina N.1, Russa, Marie La1, Wing Hung Wong3,7, Keji Zhao2, Qi, Lei S.1,8,9 stanley.qi@stanford.edu
Publikováno v:
Science. 9/2/2022, Vol. 377 Issue 6610, p1077-1085. 9p. 6 Color Photographs.
Autor:
Tianpeng Gu, Dapeng Hao, Junsung Woo, Teng-Wei Huang, Lei Guo, Xueqiu Lin, Anna G. Guzman, Ayala Tovy, Carina Rosas, Mira Jeong, Yubin Zhou, Benjamin Deneen, Yun Huang, Wei Li, Margaret A. Goodell
Publikováno v:
Nat Genet
DNA methyltransferase 3a (DNMT3A) plays a crucial role during mammalian development. Two isoforms of DNMT3A are differentially expressed from stem cells to somatic tissues, but their individual functions remain largely uncharacterized. Here we report
Autor:
Lucie Y. Guo, Jing Bian, Alexander E. Davis, Pingting Liu, Hannah R. Kempton, Xiaowei Zhang, Augustine Chemparathy, Baokun Gu, Xueqiu Lin, Draven A. Rane, Xiaoshu Xu, Ryan M. Jamiolkowski, Yang Hu, Sui Wang, Lei S. Qi
Publikováno v:
Nature Cell Biology. 24:590-600
Multiplexed modulation of endogenous genes is crucial for sophisticated gene therapy and cell engineering. CRISPR-Cas12a systems enable versatile multiple-genomic-loci targeting by processing numerous CRISPR RNAs (crRNAs) from a single transcript; ho