Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Xuekun Wang"'
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
A series of para-quinone methide derivatives were evaluated their anti-inflammatory activity. Through the screening of the lipopolysaccharide (LPS)-induced inflammatory cell model in Raw264.7 cells, it was found that the inhibitory activity of meta-s
Externí odkaz:
https://doaj.org/article/47f386b327044e26ab45954121a3bdbd
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
AbstractIn this study, four series of piperazine derivatives were designed, synthesised and subjected to biological test, and compound 6a with potential antidepressant activity was obtained. An affinity assay of compound 6a with 5-hydroxytryptamine (
Externí odkaz:
https://doaj.org/article/895c3580ab554513b587867a61650fd5
Publikováno v:
Molecules, Vol 29, Iss 21, p 5077 (2024)
Antimetabolite antitumor drugs interfere with nucleic acid and DNA synthesis, causing cancer cell death. However, they also affect rapidly dividing normal cells and cause serious side effects. Doxifluridine (5′-deoxy-5-fluorouridine [5′-DFUR]), a
Externí odkaz:
https://doaj.org/article/06502ad1158b4f7da083177d11b144c5
Autor:
Xuekun Wang, Jin Xu, Qingcheng Guo, Zhenhua Li, Jiawei Cao, Rongrong Fu, Mengjiao Xu, Xiang Zhao, Fugui Wang, Xinmeng Zhang, Taimin Dong, Xu Li, Weizhu Qian, Shen Hou, Lusha Ji, Dapeng Zhang, Huaizu Guo
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
The Chinese hamster ovarian (CHO) cells serve as a common choice in biopharmaceutical production, traditionally cultivated in stirred tank bioreactors (STRs). Nevertheless, the pursuit of improved protein quality and production output for commercial
Externí odkaz:
https://doaj.org/article/f622f91f8c874caca261685bcf9c9c2e
Publikováno v:
Antibiotics, Vol 13, Iss 8, p 744 (2024)
Infections caused by multidrug-resistant pathogens have emerged as a serious threat to public health. To develop new antibacterial agents to combat such drug-resistant bacteria, a class of novel amphiphilic xanthoangelol-derived compounds were design
Externí odkaz:
https://doaj.org/article/6100413314cf497e941684849408cbd8
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
The aging population has become an issue that cannot be ignored, and research on aging is receiving increasing attention. PL 1-3 possesses diverse pharmacological properties including anti-oxidative stress, inhibits inflammatory responses and anti-ap
Externí odkaz:
https://doaj.org/article/cb00e6aa1b3e41c28ee36ea0c7bc353f
Autor:
Zhenzhen Gao, Xiaoming Zhou, Dandan Liu, Baoshen Nie, Hanchong Lu, Xiaotong Chen, Jiahui Wu, Lei Li, Xuekun Wang
Publikováno v:
Molecules, Vol 29, Iss 11, p 2593 (2024)
In this paper, an interesting γ′-carbon 1,6-conjugate addition for phosphine-catalyzed α-succinimide substituted allenoates has been disclosed. A wide array of substrates was found to participate in the reaction, resulting in the production of di
Externí odkaz:
https://doaj.org/article/51ea62abd5754de7b993e00eca45a66c
Autor:
Yuefeng Zhang, Aijuan Zhao, Lijun Mu, Xiao Teng, Yingxin Ma, Ru Li, Kang Lei, Lusha Ji, Xuekun Wang, Pan Li
Publikováno v:
Plants, Vol 13, Iss 9, p 1171 (2024)
Nicosulfuron, an acetolactate synthase (ALS) inhibitor herbicide, is a broad-spectrum and highly effective post-emergence herbicide. Glycosyltransferases (GTs) are widely found in organisms and transfer sugar molecules from donors to acceptors to for
Externí odkaz:
https://doaj.org/article/d4ec9aa366494e7b9bda09c9faff667f
Publikováno v:
Molecules, Vol 29, Iss 1, p 86 (2023)
With the intensification of population aging, aging-related diseases are attracting more and more attention, thus, the study of aging mechanisms and anti-aging drugs is becoming increasingly urgent. Resveratrol is a potential candidate as an anti-agi
Externí odkaz:
https://doaj.org/article/899eae5ba54847ea8e2a91ba441f2bbc
Autor:
Xuekun Wang, Mario Andrea Marchisio
Publikováno v:
Synthetic and Systems Biotechnology, Vol 6, Iss 4, Pp 254-261 (2021)
The need for co-ordinate, high-level, and stable expression of multiple genes is essential for the engineering of biosynthetic circuits and metabolic pathways. This work outlines the functionality and design of IRES- and 2 A-peptide-based constructs
Externí odkaz:
https://doaj.org/article/8c7a8fae5c8a49088ab4f161f7f45c1a