Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Xuejun Cai, Zhang"'
Autor:
Yiqing Wei, Zhuoya Yu, Lili Wang, Xiaojing Li, Na Li, Qinru Bai, Yuhang Wang, Renjie Li, Yufei Meng, Hao Xu, Xianping Wang, Yanli Dong, Zhuo Huang, Xuejun Cai Zhang, Yan Zhao
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract The voltage-gated calcium channel CaV1.2 is essential for cardiac and vessel smooth muscle contractility and brain function. Accumulating evidence demonstrates that malfunctions of CaV1.2 are involved in brain and heart diseases. Pharmacolog
Externí odkaz:
https://doaj.org/article/706f3355e9a64b0ca96ce68fc3837a0d
Autor:
Yang Yang, Hye Jin Kang, Ruogu Gao, Jingjing Wang, Gye Won Han, Jeffrey F. DiBerto, Lijie Wu, Jiahui Tong, Lu Qu, Yiran Wu, Ryan Pileski, Xuemei Li, Xuejun Cai Zhang, Suwen Zhao, Terry Kenakin, Quan Wang, Raymond C. Stevens, Wei Peng, Bryan L. Roth, Zihe Rao, Zhi-Jie Liu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Hydroxyl-carboxylic acid receptor 2 (HCA2) functions as a high-affinity receptor for nicotinic acid (vitamin B3). Here, authors report the cryo-EM structure of the HCA2-Gi complex with the agonist MK-6892 and inactive state crystal structures of muta
Externí odkaz:
https://doaj.org/article/f2f56268a33144af8505eff4c3edac34
Autor:
Yiwei Gao, Shuai Xu, Xiaoli Cui, Hao Xu, Yunlong Qiu, Yiqing Wei, Yanli Dong, Boling Zhu, Chao Peng, Shiqi Liu, Xuejun Cai Zhang, Jianyuan Sun, Zhuo Huang, Yan Zhao
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
The CaV2.3 channel is involved in synaptic plasticity and neurological disorders. Here, authors resolve the human CaV2.3 structure to explore functional heterogeneity of VSDs and elucidated the closed- and open-state inactivation mechanisms of the ch
Externí odkaz:
https://doaj.org/article/31904ce1f2d8423dbb6f6cc958e2934c
Autor:
Xiaojing Li, Feng Xu, Hao Xu, Shuli Zhang, Yiwei Gao, Hongwei Zhang, Yanli Dong, Yanchun Zheng, Bei Yang, Jianyuan Sun, Xuejun Cai Zhang, Yan Zhao, Daohua Jiang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
NaV1.3 is involved in neuronal development, hormone secretion and pain perception. Here, the authors elucidate the molecular mechanism for modulation of NaV1.3 by a site-2 neurotoxin bulleyaconitine A and a subtype selective antagonist ICA121431.
Externí odkaz:
https://doaj.org/article/4638d0c72f164f5d8a96ae7095873380
Autor:
Yanli Dong, Yiwei Gao, Shuai Xu, Yuhang Wang, Zhuoya Yu, Yue Li, Bin Li, Tian Yuan, Bei Yang, Xuejun Cai Zhang, Daohua Jiang, Zhuo Huang, Yan Zhao
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109931- (2021)
Summary: N-type voltage-gated calcium (CaV) channels mediate Ca2+ influx at presynaptic terminals in response to action potentials and play vital roles in synaptogenesis, release of neurotransmitters, and nociceptive transmission. Here, we elucidate
Externí odkaz:
https://doaj.org/article/3f815d9bfcb64a66b3a15ec8b32f971b
Autor:
Yiqing Wei, Zhuoya Yu, Lili Wang, Xiaojing Li, Na Li, Qinru Bai, Yuhang Wang, Renjie Li, Yufei Meng, Hao Xu, Xianping Wang, Yanli Dong, Zhuo Huang, Xuejun Cai Zhang, Yan Zhao
Publikováno v:
Nature Communications; 3/30/2024, Vol. 15 Issue 1, p1-11, 11p, 4 Graphs
Publikováno v:
eLife, Vol 8 (2019)
Multiple subtypes of dopamine receptors within the GPCR superfamily regulate neurological processes through various downstream signaling pathways. A crucial question about the dopamine receptor family is what structural features determine the subtype
Externí odkaz:
https://doaj.org/article/f2dd1514f1fb4cdfbfc8e25d3ba32b2f
Autor:
Hang Li, Yiwei Gao, Yanli Dong, Xuejun Cai Zhang, Yuhan Ge, Bin Li, Yun Stone Shi, Jiahui Sun, Weidong An, Yuhang Wang, Yan Zhao, Lingli He, Bei Yang
Glutamate-gated kainate receptors are ubiquitous in the central nervous system of vertebrates, mediate synaptic transmission at the postsynapse and modulate transmitter release at the presynapse1–7. In the brain, the trafficking, gating kinetics an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a7f34576e70c99e4838724be773f99b
Autor:
Yiwei Gao, Shuai Xu, Xiaoli Cui, Hao Xu, Yunlong Qiu, Yiqing Wei, Yanli Dong, Boling Zhu, Chao Peng, Shiqi Liu, Xuejun Cai Zhang, Jianyuan Sun, Zhuo Huang, Yan Zhao
High-voltage-activated R-type CaV2.3 channel plays pivotal roles in many physiological activities and is implicated in epilepsy, convulsions, and other neurodevelopmental impairments. Here, we determine the high-resolution cryo-electron microscopy (c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::740aea160856adb47e27ce756d824fd4
https://doi.org/10.1101/2022.12.19.521133
https://doi.org/10.1101/2022.12.19.521133
Autor:
Yanli Dong, Hang Li, Alina Ilie, Yiwei Gao, Annie Boucher, Xuejun Cai Zhang, John Orlowski, Yan Zhao
Publikováno v:
Science Advances. 8
Sodium-proton exchanger 3 (NHE3/SLC9A3) located in the apical membrane of renal and gastrointestinal epithelia mediates salt and fluid absorption and regulates pH homeostasis. As an auxiliary regulatory factor of NHE proteins, calcineurin B homologou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05eee619cf1f2abe7f4cee507fd9fe96
https://doi.org/10.1126/sciadv.abn3925
https://doi.org/10.1126/sciadv.abn3925