Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Xuejia Kang"'
Publikováno v:
Pharmaceutics, Vol 16, Iss 9, p 1228 (2024)
Chimeric antigen receptor (CAR) T cell therapy has emerged as a groundbreaking treatment for hematological cancers, yet it faces significant hurdles, particularly regarding its efficacy in solid tumors and concerning associated adverse effects. This
Externí odkaz:
https://doaj.org/article/59015efb40964d1bb5d9c11e268d11c8
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Metabolic reprogramming is a hallmark of cancers, but pan-cancer level roles of lipid metabolism in cancer development are remains poorly understood. We investigated the possible roles of lipid metabolic genes (LMGs) in 14 cancer types. The
Externí odkaz:
https://doaj.org/article/147b8e80138e409aa82bcd1599608d83
Autor:
Chetan Pundkar, Ferrin Antony, Xuejia Kang, Amarjit Mishra, R. Jayachandra Babu, Pengyu Chen, Feng Li, Amol Suryawanshi
Publikováno v:
Heliyon, Vol 9, Iss 6, Pp e16688- (2023)
The aberrant activation of Wnt/β-catenin signaling in tumor cells and immune cells in the tumor microenvironment (TME) promotes malignant transformation, metastasis, immune evasion, and resistance to cancer treatments. The increased Wnt ligand expre
Externí odkaz:
https://doaj.org/article/d0e476ae385048e2814172ef12023c24
Publikováno v:
Pharmaceutics, Vol 16, Iss 2, p 251 (2024)
Immunosuppressive elements within the tumor microenvironment are the primary drivers of tumorigenesis and malignant advancement. The presence, as well as the crosstalk between myeloid-derived suppressor cells (MDSCs), osteosarcoma-associated macropha
Externí odkaz:
https://doaj.org/article/484c121b8f044d4ea53f7872a71ca876
Autor:
Xuejia Kang, Yongzhuo Huang, Huiyuan Wang, Sanika Jadhav, Zongliang Yue, Amit K. Tiwari, R. Jayachandra Babu
Publikováno v:
Pharmaceutics, Vol 16, Iss 1, p 61 (2023)
The tumor microenvironment (TME) is pivotal in tumor growth and metastasis, aligning with the “Seed and Soil” theory. Within the TME, tumor-associated macrophages (TAMs) play a central role, profoundly influencing tumor progression. Strategies ta
Externí odkaz:
https://doaj.org/article/0e033b9300234d20a1e62a7ac4a4f198
Autor:
Yuan Ma, Nicola Murgia, Yu Liu, Zixuan Li, Chaweewan Sirakawin, Ruslan Konovalov, Nikolai Kovzel, Yang Xu, Xuejia Kang, Anshul Tiwari, Patrick Malonza Mwangi, Donglei Sun, Holger Erfle, Witold Konopka, Qingxuan Lai, Syeda Sadia Najam, Ilya A. Vinnikov
Publikováno v:
Molecular Metabolism, Vol 61, Iss , Pp 101507- (2022)
Objective: Obesity, a growing threat to the modern society, represents an imbalance of metabolic queues that normally signal to the arcuate hypothalamic nucleus, a critical brain region sensing and regulating energy homeostasis. This is achieved by v
Externí odkaz:
https://doaj.org/article/8c533b024cce4a5abfb4fbffd651c7c4
Autor:
Xuejia Kang, Sanika Jadhav, Manjusha Annaji, Chung-Hui Huang, Rajesh Amin, Jianzhong Shen, Charles R. Ashby, Amit K. Tiwari, R. Jayachandra Babu, Pengyu Chen
Publikováno v:
Pharmaceutics, Vol 15, Iss 6, p 1567 (2023)
Disulfiram (DSF) is a thiocarbamate based drug that has been approved for treating alcoholism for over 60 years. Preclinical studies have shown that DSF has anticancer efficacy, and its supplementation with copper (CuII) significantly potentiates the
Externí odkaz:
https://doaj.org/article/fddf486e54154ddf9dc9752b92d103d3
Autor:
Xuejia Kang, Qi Wang, Siqi Wu, Chuanyu Wang, Manjusha Annaji, Chung-Hui Huang, Jianzhong Shen, Pengyu Chen, R. Jayachandra Babu
Publikováno v:
Biomolecules, Vol 13, Iss 5, p 744 (2023)
Therapeutic strategies for ARID1A-mutant ovarian cancers are limited. Higher basal reactive oxygen species (ROS) and lower basal glutathione (GSH) empower the aggressive proliferation ability and strong metastatic property of OCCCs, indicated by the
Externí odkaz:
https://doaj.org/article/c6d4a8faa4974807963c66a2624a08d2
Autor:
Qin Xu, Bing Wang, Yang He, Zening Zheng, Jiaxin Zhang, Jizong Jiang, Wenyuan Zhang, Xiaopeng Mo, Xuejia Kang, Yongzhuo Huang
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background Glioblastoma (GBM) treatment is undermined by the suppressive tumor immune microenvironment (TIME). Seek for effective methods for brain TIME modulation is a pressing need. However, there are two major challenges against achieving the goal
Externí odkaz:
https://doaj.org/article/0dda15541a5146faaf6598e56e03b49a
Autor:
Ferrin Antony, Xuejia Kang, Chetan Pundkar, Chuanyu Wang, Amarjit Mishra, Pengyu Chen, R. Jayachandra Babu, Amol Suryawanshi
Publikováno v:
International Journal of Pharmaceutics. 640:123043
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bec867cf395b1e17aff03ead46a0db6
https://doi.org/10.1016/j.ijpharm.2023.123043
https://doi.org/10.1016/j.ijpharm.2023.123043