Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Xueji WU"'
Publikováno v:
Cell Death and Disease, Vol 13, Iss 7, Pp 1-19 (2022)
Abstract As a substrate and major effector of the mammalian target of rapamycin complex 1 (mTORC1), the biological functions of ribosomal protein S6 kinase (S6K) have been canonically assigned for cell size control by facilitating mRNA transcription,
Externí odkaz:
https://doaj.org/article/8893c1f5511440e3becb3e29ca2cca71
Autor:
Qiwei Jiang, Xiaomei Zhang, Xiaoming Dai, Shiyao Han, Xueji Wu, Lei Wang, Wenyi Wei, Ning Zhang, Wei Xie, Jianping Guo
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
The direct upstream regulation of PDK1 is not fully understood. Here the authors demonstrate that S6K1 directly phosphorylates PDK1 to inhibit AKT kinase activity and its ability to drive tumourigenesis.
Externí odkaz:
https://doaj.org/article/dd74b68e0cca4a7483049e2018684696
Autor:
Jing Liao, Xueji Wu, Caixuan Wang, Xiaochun Xiao, Yiyuan Cai, Min Wu, Yuyang Liu, Xiongfei Chen, Shaolong Wu, Yung Jen Yang, Dong (Roman) Xu
Publikováno v:
BMC Geriatrics, Vol 20, Iss 1, Pp 1-11 (2020)
Abstract Background China’s limited health care resources cannot meet the needs of chronic disease treatment and management of its rapid growing ageing population. The improvement and maintenance of patient’s self-management is essential to disea
Externí odkaz:
https://doaj.org/article/b142ba6f78bf45d7adf8037542ceb127
Autor:
Jianping Guo, Ji Cheng, Nana Zheng, Xiaomei Zhang, Xiaoming Dai, Linli Zhang, Changjiang Hu, Xueji Wu, Qiwei Jiang, Depei Wu, Hitoshi Okada, Pier Paolo Pandolfi, Wenyi Wei
Publikováno v:
Advanced Science, Vol 8, Iss 18, Pp n/a-n/a (2021)
Abstract Copper plays pivotal roles in metabolic homoeostasis, but its potential role in human tumorigenesis is not well defined. Here, it is revealed that copper activates the phosphoinositide 3‐kinase (PI3K)‐protein kinase B (PKB, also termed A
Externí odkaz:
https://doaj.org/article/5e98693847e44d0daa8c582e1450c2bd
Autor:
Yuyang Liu, Xiaocun Xiao, Chaonan Peng, Tianyi Zhao, Yanjuan Wu, Wanwen Yu, Liping Ou, Xiongfei Chen, Xueji Wu, Dong Roman Xu, Jing Liao
Publikováno v:
Frontiers in Public Health, Vol 9 (2021)
Background: To mobilize family's positive involvement in improving and sustaining self-management activities of older adults with diabetes, we developed a couple-based collaborative management model (CCMM) for community-dwelling older Chinese.Methods
Externí odkaz:
https://doaj.org/article/4c8a27f2b7f7474492b221e1d60289f5
Publikováno v:
BMC Public Health, Vol 19, Iss 1, Pp 1-9 (2019)
Abstract Background Health literacy and health-information seeking behaviour (HISB) play vital roles in health outcome improvements. This study examines the extent of income-related inequality in health literacy and health-information seeking as well
Externí odkaz:
https://doaj.org/article/c37961fb49ec40208394abe5fa39ed12
Autor:
Yuchen Wang, Huali Xu, Wenwen Fu, Zeyuan Lu, Minyu Guo, Xueji Wu, Mingyang Sun, Yanzhe Liu, Xiaofeng Yu, Dayun Sui
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
20(S)-Protopanaxadiol (PPD) is one of the major active metabolites in ginseng saponin. Our previous studies revealed a broad spectrum of antitumor effects of PPD. Angiotensin II (Ang II), the biologically active peptide of the renin-angiotensin syste
Externí odkaz:
https://doaj.org/article/f24acdb50e7d4aa9a951aea8ecb06b9e
Autor:
Xiaomei DONG, Jiaming RAO, Yunfeng YE, Minhui PANG, Jianwei YANG, Haiqing WANG, Jiayi ZHANG, Bingying PAN, Xueji WU, Xiongfei CHEN
Publikováno v:
Iranian Journal of Public Health, Vol 47, Iss 2 (2018)
Background: We aimed to describe the trends and associated factors of hypertension among residents aged ³15 yr in Guangzhou, China. Methods: Three standardized cross-sectional health surveys were conducted in 2004, 2009 and 2013 using a multi-stage
Externí odkaz:
https://doaj.org/article/ddc07cb5a638493a8d2c0d1382e66830
Autor:
Huiying Liang, Xi Chen, Qiaozhu Chen, Yulin Wang, Xueji Wu, Yaohui Li, Bingying Pan, Huazhang Liu, Ming Li
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74121 (2013)
OBJECTIVES: This research aimed to (i) determine the prevalence of metabolic syndrome (MetS) and its components; (ii) assess factors associated with MetS, and (iii) define optimal ethnic-specific cutoffs of obesity- and atherogenic-based markers to p
Externí odkaz:
https://doaj.org/article/a460428b8b6243f99e218a08f06aace8
Autor:
Le Zhao, W David Tolbert, Bryan Ericksen, Changyou Zhan, Xueji Wu, Weirong Yuan, Xu Li, Marzena Pazgier, Wuyuan Lu
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e78937 (2013)
HNP1 is a human alpha defensin that forms dimers and multimers governed by hydrophobic residues, including Tyr¹⁶, Ile²⁰, Leu²⁵, and Phe²⁸. Previously, alanine scanning mutagenesis identified each of these residues and other hydrophobic re
Externí odkaz:
https://doaj.org/article/c17d0909fdc345c2ba7a22a763017c52