Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Xuehua Zheng"'
Autor:
Deyan Wu, Xuehua Zheng, Runduo Liu, Zhe Li, Zan Jiang, Qian Zhou, Yue Huang, Xu-Nian Wu, Chen Zhang, Yi-You Huang, Hai-Bin Luo
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 3, Pp 1351-1362 (2022)
Scaffold hopping refers to computer-aided screening for active compounds with different structures against the same receptor to enrich privileged scaffolds, which is a topic of high interest in organic and medicinal chemistry. However, most approache
Externí odkaz:
https://doaj.org/article/35e8bd3e764c47488baa224bfba360df
Autor:
Liqiang Feng, Qian Wang, Chao Shan, Chenchen Yang, Ying Feng, Jia Wu, Xiaolin Liu, Yiwu Zhou, Rendi Jiang, Peiyu Hu, Xinglong Liu, Fan Zhang, Pingchao Li, Xuefeng Niu, Yichu Liu, Xuehua Zheng, Jia Luo, Jing Sun, Yingying Gu, Bo Liu, Yongcun Xu, Chufang Li, Weiqi Pan, Jincun Zhao, Changwen Ke, Xinwen Chen, Tao Xu, Nanshan Zhong, Suhua Guan, Zhiming Yuan, Ling Chen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
A vaccine protecting from SARS-CoV-2 infection is needed. Here the authors generate a replication-incompetent adenovirus based vaccine expressing SARS-CoV-2 spike, show protection from infection in non-human primates, and analyze the immune response
Externí odkaz:
https://doaj.org/article/b2722cb9b68f42f095aa1611002a534b
Autor:
Xuehua Zheng, Xia Rong, Ying Feng, Xikui Sun, Liang Li, Qian Wang, Min Wang, Wenkuan Liu, Chufang Li, Yiyu Yang, Rong Zhou, Jiahai Lu, Liqiang Feng, Ling Chen
Publikováno v:
Emerging Microbes and Infections, Vol 6, Iss 1, Pp 1-8 (2017)
Re-emerging human adenovirus types 14 (Ad14) and 55 (Ad55) have caused severe respiratory diseases and even deaths during recent outbreaks. However, the seroprevalence of neutralizing antibodies (nAbs) in healthy adults, which may reflect previous ci
Externí odkaz:
https://doaj.org/article/cb2c9590e50a4d208f564a80158131cd
Autor:
Xianmiao Ye, Lijun Xiao, Xuehua Zheng, Jinlin Wang, Tao Shu, Ying Feng, Xinglong Liu, Wan Su, Qian Wang, Chufang Li, Ling Chen, Liqiang Feng
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Human adenoviruses type 4 (HAdV4) and 7 (HAdV7) are two major respiratory pathogens and sporadically cause outbreaks of acute respiratory diseases. The neutralizing antibody (nAb) response to these two adenoviruses in civilian populations, which is i
Externí odkaz:
https://doaj.org/article/2cee3d3457824d5ea38c1c9ca922a3b1
Autor:
Wenhao Wu, Xintong Liang, Guoquan Xie, Langdi Chen, Weixiong Liu, Guolin Luo, Peiquan Zhang, Lihong Yu, Xuehua Zheng, Hong Ji, Chao Zhang, Wei Yi
Publikováno v:
Molecules, Vol 23, Iss 10, p 2540 (2018)
A series of novel ligustrazine derivatives 8a–r were designed, synthesized, and evaluated as multi-targeted inhibitors for anti-Alzheimer’s disease (AD) drug discovery. The results showed that most of them exhibited a potent ability to inhibit bo
Externí odkaz:
https://doaj.org/article/eb782a72899441408b0ec518370d0ece
Autor:
Zhe Li, Runduo Liu, Hai-Bin Luo, Chen Zhang, Deyan Wu, Zan Jiang, Qian Zhou, Xu-Nian Wu, Yue Huang, Xuehua Zheng, Yi-You Huang
Publikováno v:
Acta Pharmaceutica Sinica B. 12:1351-1362
Scaffold hopping refers to computer-aided screening for active compounds with different structures against the same receptor to enrich privileged scaffolds, which is a topic of high interest in organic and medicinal chemistry. However, most approache
Corydalis decumbens Alleviates the Migration, Phagocytosis, and Inflammatory Response of Macrophages
Publikováno v:
Evidence-Based Complementary and Alternative Medicine.
Background. The role of Corydalis decumbens (CD) in macrophage activation remains unclear, particularly in the Ras homolog family member A (RhoA) signaling pathway. Therefore, the present study aimed to investigate the effect of CD on the viability,
Publikováno v:
Evidence-based Complementary and Alternative Medicine : eCAM
Evidence-Based Complementary and Alternative Medicine, Vol 2020 (2020)
Evidence-Based Complementary and Alternative Medicine, Vol 2020 (2020)
Yunvjian (YNJ) is a traditional Chinese medicine formula adopted to prevent and treat diabetes. Our previous results from animal experiments showed that YNJ decreased blood glucose. This study aimed to examine the effect of high glucose and high lipi
Autor:
Haisu Yi, Qian Wang, Jiankai Deng, Hengchun Li, Yingkun Zhang, Zhilong Chen, Tianxin Ji, Wenming Liu, Xuehua Zheng, Qinghua Ma, Xinxin Sun, Yudi Zhang, Xuegao Yu, Mengzhang He, Ling Chen, Ying Feng
Publikováno v:
Virologica Sinica. 37(5)
Human adenoviruses type 26 (HAdV26) and type 35 (HAdV35) have increasingly become the choice of adenovirus vectors for vaccine application. However, the population pre-existing immunity to these two adenoviruses in China, which may reduce vaccine eff
Autor:
Liu Xiaolin, Nanshan Zhong, Jia Wu, Fan Zhang, Xuefeng Niu, Chufang Li, Yichu Liu, Jia Luo, Xinglong Liu, Ying Feng, Jincun Zhao, Peiyu Hu, Chenchen Yang, Guan Suhua, Ren-Di Jiang, Xinwen Chen, Ling Chen, Zhiming Yuan, Xuehua Zheng, Qian Wang, Yingying Gu, Chao Shan, Liqiang Feng, Yiwu Zhou, Jing Sun, Yongcun Xu, Changwen Ke, Tao Xu, Weiqi Pan, Bo Liu, Pingchao Li
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
The rapid spread of coronavirus SARS-CoV-2 greatly threatens global public health but no prophylactic vaccine is available. Here, we report the generation of a replication-incompetent recombinant serotype 5 adenovirus, Ad5-S-nb2, carrying a codon-opt