Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Xuefang Pan"'
Autor:
Xuefang Pan, Antoine Caillon, Shuxian Fan, Shaukat Khan, Shunji Tomatsu, Alexey V. Pshezhetsky
Publikováno v:
Cells, Vol 13, Iss 10, p 877 (2024)
Mucopolysaccharidosis III type C (MPS IIIC) is an untreatable neuropathic lysosomal storage disease caused by a genetic deficiency of the lysosomal N-acetyltransferase, HGSNAT, catalyzing a transmembrane acetylation of heparan sulfate. HGSNAT is a tr
Externí odkaz:
https://doaj.org/article/fd13f0cf23ba4e43b07b59d0a19541e4
Autor:
Rui Sun, Tao Wu, Shu Xing, Sheng Wei, John K. Bielicki, Xuefang Pan, Mingyang Zhou, Jianbin Chen
Publikováno v:
Journal of Pharmacological Sciences, Vol 151, Iss 2, Pp 110-118 (2023)
Caffeic acid has been indicated to benefit cholesterol balance, but the effect of pure caffeic acid on atherosclerosis in vivo has not been tested. Given that atherosclerosis and Alzheimer's disease share common features including distracted lipid ba
Externí odkaz:
https://doaj.org/article/bfbacbe8c32546bb9f6300a59c007abb
Autor:
Ikhui Kho, Ekaterina P. Demina, Xuefang Pan, Irene Londono, Christopher W. Cairo, Luisa Sturiale, Angelo Palmigiano, Angela Messina, Domenico Garozzo, Roth-Visal Ung, Fabrice Mac-Way, Éric Bonneil, Pierre Thibault, Mathieu Lemaire, Carlos R. Morales, Alexey V. Pshezhetsky
Publikováno v:
JCI Insight, Vol 8, Iss 20 (2023)
Sialidosis is an ultra-rare multisystemic lysosomal disease caused by mutations in the neuraminidase 1 (NEU1) gene. The severe type II form of the disease manifests with a prenatal/infantile or juvenile onset, bone abnormalities, severe neuropatholog
Externí odkaz:
https://doaj.org/article/020e7d15b3464b17be3a39d683d06c32
Autor:
Camila Pará, Poulomee Bose, Luigi Bruno, Erika Freemantle, Mahsa Taherzadeh, Xuefang Pan, Chanshuai Han, Peter S. McPherson, Jean-Claude Lacaille, Éric Bonneil, Pierre Thibault, Claire O’Leary, Brian Bigger, Carlos Ramon Morales, Graziella Di Cristo, Alexey V. Pshezhetsky
Publikováno v:
JCI Insight, Vol 6, Iss 15 (2021)
The majority of patients affected with lysosomal storage disorders (LSD) exhibit neurological symptoms. For mucopolysaccharidosis type IIIC (MPSIIIC), the major burdens are progressive and severe neuropsychiatric problems and dementia, primarily thou
Externí odkaz:
https://doaj.org/article/410c3252a7a24808ba1808d744c3aabd
Autor:
Ekaterina P. Demina, Victoria Smutova, Xuefang Pan, Anne Fougerat, Tianlin Guo, Chunxia Zou, Radhika Chakraberty, Brendan D. Snarr, Tze C. Shiao, Rene Roy, Alexander N. Orekhov, Taeko Miyagi, Muriel Laffargue, Donald C. Sheppard, Christopher W. Cairo, Alexey V. Pshezhetsky
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 4 (2021)
Background Chronic vascular disease atherosclerosis starts with an uptake of atherogenic modified low‐density lipoproteins (LDLs) by resident macrophages, resulting in formation of arterial fatty streaks and eventually atheromatous plaques. Increas
Externí odkaz:
https://doaj.org/article/e7dc017e27064f1db8d43dacecc291d0
Autor:
Anne Fougerat, Xuefang Pan, Victoria Smutova, Nikolaus Heveker, Christopher W. Cairo, Tarik Issad, Bruno Larrivée, Jeffrey A. Medin, Alexey V. Pshezhetsky
Publikováno v:
Molecular Metabolism, Vol 12, Iss , Pp 76-88 (2018)
Objectives: Neuraminidase 1 (NEU1) cleaves terminal sialic acids of glycoconjugates during lysosomal catabolism. It also modulates the structure and activity of cellular surface receptors affecting diverse pathways. Previously we demonstrated that NE
Externí odkaz:
https://doaj.org/article/541e8d755b704d37851988c197c97c88
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0172854 (2017)
Vasoactive and mitogenic peptide, endothelin-1 (ET-1) plays an important role in physiology of the ocular tissues by regulating the growth of corneal epithelial cells and maintaining the hemodynamics of intraocular fluids. We have previously establis
Externí odkaz:
https://doaj.org/article/8ad01cae92694c4ab4cf66615eada381
Autor:
Carlos R. Morales, Lubov S. Grigoryeva, Xuefang Pan, Luigi Bruno, Gilles Hickson, Michael H. Ngo, Christopher R. McMaster, Mark E. Samuels, Alexey V. Pshezhetsky
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 1, Iss C, Pp 407-411 (2014)
Heterozygous mutations in the UBIAD1 gene cause Schnyder corneal dystrophy characterized by abnormal cholesterol and phospholipid deposits in the cornea. Ubiad1 protein was recently identified as Golgi prenyltransferase responsible for biosynthesis o
Externí odkaz:
https://doaj.org/article/cfd9cf3fbd0747f3aa66e5d116e39e7b
Autor:
Elizaveta Katorcha, Nina Klimova, Natallia Makarava, Regina Savtchenko, Xuefang Pan, Ida Annunziata, Kohta Takahashi, Taeko Miyagi, Alexey V Pshezhetsky, Alessandra d'Azzo, Ilia V Baskakov
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0143218 (2015)
The central molecular event underlying prion diseases involves conformational change of the cellular form of the prion protein (PrPC), which is a sialoglycoprotein, into the disease-associated, transmissible form denoted PrPSc. Recent studies reveale
Externí odkaz:
https://doaj.org/article/f520cdeeb80445b8846673b7feed90cd
Autor:
Xuefang Pan, Lubov Grigoryeva, Volkan Seyrantepe, Junzheng Peng, Katrin Kollmann, Johanne Tremblay, Julie L Lavoie, Aleksander Hinek, Torben Lübke, Alexey V Pshezhetsky
Publikováno v:
PLoS Genetics, Vol 10, Iss 2, p e1004146 (2014)
The potent vasoconstrictor peptides, endothelin 1 (ET-1) and angiotensin II control adaptation of blood vessels to fluctuations of blood pressure. Previously we have shown that the circulating level of ET-1 is regulated through its proteolytic cleava
Externí odkaz:
https://doaj.org/article/a52a5f441dab48ebbd8044eab43b9068