Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Xuedong Chi"'
Autor:
Xuedong Chi, Meir1, Anselmi, Kristin1, Watkins, Simon2, Gandhi, Chandrashekhar R.1,3 Gandhies@msx.upmc.edu
Publikováno v:
British Journal of Pharmacology. Jun2003, Vol. 139 Issue 4, p765-774. 10p. 9 Graphs.
Autor:
Emily K. Larsen, Anas Younes, Ajay K. Gopal, Eric L. Sievers, Joseph M. Connors, Andreas Engert, Andrei R. Shustov, Barbara Pro, Dana A. Kennedy, Xuedong Chi
Background: Independent central review of clinical imaging remains the standard for oncology clinical trials with registration potential. A limited independent central review strategy has been proposed for solid tumor trials based on concordance betw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4db6f8a44d2ec67f8329f3a190e414b3
https://europepmc.org/articles/PMC5572138/
https://europepmc.org/articles/PMC5572138/
Autor:
Xuedong Chi, Paul P. Tak, Clarissa E. Vergunst, Danielle M. Gerlag, Lisa L. von Moltke, Michael Karol, Ellen Matzkin, Tim Wyant, T. Leach
Publikováno v:
Arthritis and rheumatism, 60(12), 3572-3581. John Wiley and Sons Inc.
Objective To assess the efficacy, safety, pharmacokinetics, and pharmacodynamics of the CC chemokine receptor CCR1 antagonist MLN3897 in patients with rheumatoid arthritis (RA) receiving methotrexate (MTX). Methods In this phase IIa, proof-of-concept
Autor:
Eric L. Sievers, Joseph M. Connors, Joseph D. Rosenblatt, Andreas Engert, Emily K. Larsen, Scott E. Smith, Kerry J. Savage, Robert T. Chen, Stephen M. Ansell, Xuedong Chi, Ajay K. Gopal, Anas Younes
We present response and survival outcomes of a pivotal phase 2 trial of the antibody-drug conjugate brentuximab vedotin in patients with relapsed/refractory Hodgkin lymphoma following autologous stem cell transplant (N = 102) after a median observati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f35e5f2d358d548f3b29b825e57e89e3
https://europepmc.org/articles/PMC4335079/
https://europepmc.org/articles/PMC4335079/
Autor:
Christopher I. Amos, Xuedong Chi, Patrick M. Lynch, J. Shawn Jones, Marsha L. Frazier, Xiangjun Gu
Publikováno v:
Clinical Cancer Research. 10:5845-5849
Purpose: Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant syndrome of familial malignancies. Colorectal and endometrial cancers are most frequently observed. The syndrome results mainly from germ-line mutations in DNA mismat
Publikováno v:
British Journal of Pharmacology. 139:765-774
Physiologically, perisinusoidal hepatic stellate cells (HSC) are quiescent and store retinoids. During liver injury and in cell culture, HSC transform into proliferating myofibroblast-like cells that express α-smooth muscle actin (α-sma) and produc
Publikováno v:
Neurological Research. 23:506-512
beta-amyloid (A beta), the major component of senile plaques in Alzheimer's disease (AD), normally circulates in the blood at nanomolar levels but is elevated in AD. Previous studies have found that high concentrations (10(-5)-10(-4) M) of A beta res
Publikováno v:
Neuroscience Letters. 290:9-12
There is increasing evidence that the cerebrovasculture may be involved in the pathology of Alzheimer's disease. Here, we report that potassium channel openers (KCOs) inhibit dose and time dependent necrosis induced by beta-amyloid (Abeta) in culture
Publikováno v:
Neurological Research. 21:345-351
Amyloid angiopathy is characterized by amyloid beta-peptide (A beta) deposition and may contribute to the cerebrovascular abnormalities that precede the onset of Alzheimer's Disease (AD). That aberrant potassium (K+) channel function occurs in AD pat
Publikováno v:
SPIE Proceedings.
Conventional monitoring of the anesthetization process relies on the measurement of the blood pressure and heart rate, and on human observations. Such measures and observations do not provide specific assessment of the depth and other aspects of anes