Zobrazeno 1 - 10
of 209
pro vyhledávání: '"Xuechu Zhen"'
Autor:
Yang Tong, Pei An, Puxian Tang, Rui Mu, Yuteng Zeng, Hang Sun, Mei Zhao, Ziyan Lv, Pan Wang, Wanjun Han, Chunshan Gui, Xuechu Zhen, Liang Han
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 6, Pp 2716-2731 (2024)
Lipogenesis is often highly upregulated in breast cancer brain metastases to adapt to intracranial low lipid microenvironments. Lipase inhibitors hold therapeutic potential but their intra-tumoral distribution is often blocked by the blood‒tumor ba
Externí odkaz:
https://doaj.org/article/63fcfa2c915e490095d73c7d7e02c137
The NTE domain of PTENα/β promotes cancer progression by interacting with WDR5 via its SSSRRSS motif
Autor:
Xiaolei Huang, Cheng Zhang, Xinci Shang, Yichang Chen, Qin Xiao, Zhengguo Wei, Guanghui Wang, Xuechu Zhen, Guoqiang Xu, Jinrong Min, Shaoming Shen, Yanli Liu
Publikováno v:
Cell Death and Disease, Vol 15, Iss 5, Pp 1-14 (2024)
Abstract PTENα/β, two variants of PTEN, play a key role in promoting tumor growth by interacting with WDR5 through their N-terminal extensions (NTEs). This interaction facilitates the recruitment of the SET1/MLL methyltransferase complex, resulting
Externí odkaz:
https://doaj.org/article/d3b06edb1e344054a5eb52a029e29ea3
Autor:
Pengju Yan, Ningning Li, Ming Ma, Zhaoli Liu, Huicui Yang, Jinnan Li, Chunlei Wan, Shuliu Gao, Shuai Li, Longtai Zheng, John L. Waddington, Lin Xu, Xuechu Zhen
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-15 (2023)
Abstract Substance use disorder remains a major challenge, with an enduring need to identify and evaluate new, translational targets for effective treatment. Here, we report the upregulation of Hypoxia-inducible factor-1α (HIF-1α) expression by rox
Externí odkaz:
https://doaj.org/article/9b23d58ed68d4f6f8c75bcff84ed78fb
Autor:
Yanli Liu, Aman Iqbal, Weiguo Li, Zuyao Ni, Yalong Wang, Jurupula Ramprasad, Karan Joshua Abraham, Mengmeng Zhang, Dorothy Yanling Zhao, Su Qin, Peter Loppnau, Honglv Jiang, Xinghua Guo, Peter J. Brown, Xuechu Zhen, Guoqiang Xu, Karim Mekhail, Xingyue Ji, Mark T. Bedford, Jack F. Greenblatt, Jinrong Min
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The SMN protein recognizes symmetric dimethylarginine by its Tudor domain, and SMN deficiency leads to spinal muscular atrophy. Here, Liu et al. discover a small molecule that binds to the SMN Tudor domain and disrupts the interaction between SMN and
Externí odkaz:
https://doaj.org/article/a0e6fffeffbb41e8b6c0ef99920dda4b
Autor:
Junjie Cheng, Rong Zhang, Zhirou Xu, Youliang Ke, Renjuan Sun, Huicui Yang, Xiaohu Zhang, Xuechu Zhen, Long-Tai Zheng
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-18 (2021)
Abstract Background Microglial activation-mediated neuroinflammation plays an important role in the progression of neurodegenerative diseases. Inflammatory activation of microglial cells is often accompanied by a metabolic switch from oxidative phosp
Externí odkaz:
https://doaj.org/article/6d3d4d626b494c44b73c826e8b0ecd7b
Autor:
Gufang Zhang, Shuangshuang Chen, Jia Jia, Chun Liu, Weipeng Wang, Hongjian Zhang, Xuechu Zhen
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Epidemiologic data reveal that diabetes patients taking metformin exhibit lower incidence of stroke and better functional outcomes during post-stroke neurologic recovery. We previously demonstrated that chronic post-ischemic administration of metform
Externí odkaz:
https://doaj.org/article/4624910ceb5142e8bcb3d0f4dd20dc49
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2020)
Alongside positive and negative symptomatology, deficits in working memory, attention, selective learning processes, and executive function have been widely documented in schizophrenia spectrum psychosis. These cognitive abnormalities are strongly as
Externí odkaz:
https://doaj.org/article/7fe34619d39a45ae9c4e583f8473d0d2
Autor:
Yafei Zhao, Panpan Wang, Shuangshuang Chen, Chaojun Han, Qiuting Yan, Longtai Zheng, Jia Jia, Zhaoxiang Ren, Xuechu Zhen
Publikováno v:
Journal of Functional Foods, Vol 33, Iss , Pp 76-84 (2017)
Dihydromyricetin (DHM), a natural flavonoid compound extracted from the fruit Ampelopsis grossedentata, exerts various pharmacological effects. We explored the neuroprotective effects of DHM following cerebral ischemia. Male ICR mice were intraperito
Externí odkaz:
https://doaj.org/article/c4b71feaab5048edb2858ad20d9c06c3
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
A large body of evidence indicates that sigma-1 receptors (Sig-1R) are important drug targets for a number of neuropsychiatric disorders. Sig-1Rs are enriched in central nervous system (CNS). In addition to neurons, both cerebral microglia and astroc
Externí odkaz:
https://doaj.org/article/ffef9a9f946145ed82db1914d95700fc
LLDT-8 protects against cerebral ischemia/reperfusion injury by suppressing post-stroke inflammation
Autor:
Yanke Chen, Li Zhang, Jingshu Ni, Xiaoyu Wang, Jian Cheng, Yuanchao Li, Xuechu Zhen, Ting Cao, Jia Jia
Publikováno v:
Journal of Pharmacological Sciences, Vol 131, Iss 2, Pp 131-137 (2016)
Aim: (5R)-5-Hydroxytriptolide (LLDT-8), an analogue of triptolide, displays lower toxicity compared to triptolide and has comparable immunosuppressive effects. We investigated the anti-inflammatory and neuroprotective effects of LLDT-8 on cerebral is
Externí odkaz:
https://doaj.org/article/9cff7bbc103148a593bcad85d8c3c7f1