Zobrazeno 1 - 10
of 303
pro vyhledávání: '"Xuechu, Zhen"'
Publikováno v:
Fundamental Research, Vol 4, Iss 6, Pp 1375-1388 (2024)
Macrophage migration inhibitory factor (MIF) is a multifunctional protein that possesses cytokine, enzyme, and endocrine activities and acts as a chaperone-like molecule. Owing to its immune-inflammatory regulatory properties, the role of MIF has lon
Externí odkaz:
https://doaj.org/article/93141dc427d345d1a52bf93f5847404d
Autor:
Yang Tong, Pei An, Puxian Tang, Rui Mu, Yuteng Zeng, Hang Sun, Mei Zhao, Ziyan Lv, Pan Wang, Wanjun Han, Chunshan Gui, Xuechu Zhen, Liang Han
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 6, Pp 2716-2731 (2024)
Lipogenesis is often highly upregulated in breast cancer brain metastases to adapt to intracranial low lipid microenvironments. Lipase inhibitors hold therapeutic potential but their intra-tumoral distribution is often blocked by the blood‒tumor ba
Externí odkaz:
https://doaj.org/article/63fcfa2c915e490095d73c7d7e02c137
The NTE domain of PTENα/β promotes cancer progression by interacting with WDR5 via its SSSRRSS motif
Autor:
Xiaolei Huang, Cheng Zhang, Xinci Shang, Yichang Chen, Qin Xiao, Zhengguo Wei, Guanghui Wang, Xuechu Zhen, Guoqiang Xu, Jinrong Min, Shaoming Shen, Yanli Liu
Publikováno v:
Cell Death and Disease, Vol 15, Iss 5, Pp 1-14 (2024)
Abstract PTENα/β, two variants of PTEN, play a key role in promoting tumor growth by interacting with WDR5 through their N-terminal extensions (NTEs). This interaction facilitates the recruitment of the SET1/MLL methyltransferase complex, resulting
Externí odkaz:
https://doaj.org/article/d3b06edb1e344054a5eb52a029e29ea3
Publikováno v:
PLoS Biology, Vol 22, Iss 7, p e3002716 (2024)
Heterologous sensitization of adenylyl cyclase (AC) results in elevated cAMP signaling transduction that contributes to drug dependence. Inhibiting cullin3-RING ligases by blocking the neddylation of cullin3 abolishes heterologous sensitization, howe
Externí odkaz:
https://doaj.org/article/730a3d481ac94ac2b6659576808641c3
Publikováno v:
Biomolecules, Vol 14, Iss 9, p 1185 (2024)
A wide array of biological abnormalities in psychotic illness appear to reflect non-cerebral involvement. This review first outlines the evidence for such a whole-body concept of schizophrenia pathobiology, focusing particularly on cardiovascular dis
Externí odkaz:
https://doaj.org/article/5a97af81fadd4bde93b7d0acea606acc
Autor:
Pengju Yan, Ningning Li, Ming Ma, Zhaoli Liu, Huicui Yang, Jinnan Li, Chunlei Wan, Shuliu Gao, Shuai Li, Longtai Zheng, John L. Waddington, Lin Xu, Xuechu Zhen
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-15 (2023)
Abstract Substance use disorder remains a major challenge, with an enduring need to identify and evaluate new, translational targets for effective treatment. Here, we report the upregulation of Hypoxia-inducible factor-1α (HIF-1α) expression by rox
Externí odkaz:
https://doaj.org/article/9b23d58ed68d4f6f8c75bcff84ed78fb
Autor:
Yanli Liu, Aman Iqbal, Weiguo Li, Zuyao Ni, Yalong Wang, Jurupula Ramprasad, Karan Joshua Abraham, Mengmeng Zhang, Dorothy Yanling Zhao, Su Qin, Peter Loppnau, Honglv Jiang, Xinghua Guo, Peter J. Brown, Xuechu Zhen, Guoqiang Xu, Karim Mekhail, Xingyue Ji, Mark T. Bedford, Jack F. Greenblatt, Jinrong Min
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The SMN protein recognizes symmetric dimethylarginine by its Tudor domain, and SMN deficiency leads to spinal muscular atrophy. Here, Liu et al. discover a small molecule that binds to the SMN Tudor domain and disrupts the interaction between SMN and
Externí odkaz:
https://doaj.org/article/a0e6fffeffbb41e8b6c0ef99920dda4b
Autor:
Junjie Cheng, Rong Zhang, Zhirou Xu, Youliang Ke, Renjuan Sun, Huicui Yang, Xiaohu Zhang, Xuechu Zhen, Long-Tai Zheng
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-18 (2021)
Abstract Background Microglial activation-mediated neuroinflammation plays an important role in the progression of neurodegenerative diseases. Inflammatory activation of microglial cells is often accompanied by a metabolic switch from oxidative phosp
Externí odkaz:
https://doaj.org/article/6d3d4d626b494c44b73c826e8b0ecd7b
Autor:
Gufang Zhang, Shuangshuang Chen, Jia Jia, Chun Liu, Weipeng Wang, Hongjian Zhang, Xuechu Zhen
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Epidemiologic data reveal that diabetes patients taking metformin exhibit lower incidence of stroke and better functional outcomes during post-stroke neurologic recovery. We previously demonstrated that chronic post-ischemic administration of metform
Externí odkaz:
https://doaj.org/article/4624910ceb5142e8bcb3d0f4dd20dc49
Autor:
Gufang Zhang, Qi Li, Weijie Tao, Pingping Qin, Jiali Chen, Huicui Yang, Jiaojiao Chen, Hua Liu, Qijun Dai, Xuechu Zhen
Publikováno v:
Theranostics. 13:543-559
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c8aa788fb4c291bbb3c3c409385de0d
https://doi.org/10.7150/thno.77088
https://doi.org/10.7150/thno.77088