Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Xue-li Bian"'
Autor:
Xue-li Bian, Hang-zi Chen, Peng-bo Yang, Ying-ping Li, Fen-na Zhang, Jia-yuan Zhang, Wei-jia Wang, Wen-xiu Zhao, Sheng Zhang, Qi-tao Chen, Yu Zheng, Xiao-yu Sun, Xiao-min Wang, Kun-Yi Chien, Qiao Wu
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Gluconeogenesis is downregulated in hepatocellular carcinoma. Here, the authors show that nuclear receptor Nur77 acts as a tumour suppressor sustaining gluconeogenesis by enhancing phosphoenolpyruvate carboxykinase (PEPCK1) stability via regulating i
Externí odkaz:
https://doaj.org/article/08531e386b7c4c13a7c8af733ca4b208
Publikováno v:
Cell Metabolism. 33:33-50
Key pathological, including oncogenic, signaling pathways regulate the canonical functions of metabolic enzymes that serve the cellular metabolic needs. Importantly, these signaling pathways also confer a large number of metabolic enzymes to have non
Publikováno v:
The Journal of Experimental Medicine
Dysregulation in lipid metabolism is among the most prominent metabolic alterations in cancer. This review discusses current knowledge about the advances in understanding lipid metabolism regulation in cancer cells and introduces therapies that disru
Autor:
Hongfei Jiang, Dongming Xing, Zhimin Lu, Wei Guo, Xue-li Bian, Qi Xue, Lei Zhu, Yibo Gao, Fei Shao, Daqian Xu, Shuai Wang, Gaoxiang Zhao, Jie He
Publikováno v:
European journal of cancer (Oxford, England : 1990). 142
Background Metabolic enzymes have non-canonical functions and play vital roles in the regulation of various cellular activities. Phosphoenolpyruvate carboxykinase 1 (PCK1), a gluconeogenic enzyme, was recently identified as an AKT-dependent protein k
Autor:
Philip L. Lorenzi, Rui Liu, Yan Xia, Qianming Chen, Yanhua Zheng, Rilei Yu, Zhimin Lu, Xue Li Bian, Jong Ho Lee, Jingyi Li, Lin Tan
Publikováno v:
Molecular cell. 81(13)
Lipid droplets are important for cancer cell growth and survival. However, the mechanism underlying the initiation of lipid droplet lipolysis is not well understood. We demonstrate here that glucose deprivation induces the binding of choline kinase (
Autor:
Pei-pei Hou, Sheng-fu Wu, Dawang Zhou, Wenxiu Zhao, Jianming Liu, Qiao Wu, Hang-zi Chen, Xiaomin Wang, Li-juan Luo, Lu-ming Yao, Qinghua Chen, Xue-li Bian, Zhi-yuan Zhang, Jia-xin Zhou, Qi-tao Chen
Publikováno v:
Molecular cell. 78(6)
Tumor-derived extracellular vesicles are important mediators of cell-to-cell communication during tumorigenesis. Here, we demonstrated that hepatocellular carcinoma (HCC)-derived ectosomes remodel the tumor microenvironment to facilitate HCC progress
Autor:
Hang-zi Chen, Jian-ping He, Tianwei Lin, Feng-wei Li, Hong-Kui Zhang, Yong-zhen Xing, Qixu Cai, Pei-pei Hou, Pei-Qiang Huang, Yuan Wang, Bo Zhou, Qiao Wu, Xue-li Bian, Wei-jia Wang
Publikováno v:
Chemistry & Biology. 22(8):1040-1051
SummaryApoptotic resistance is becoming a significant obstacle for cancer therapy as the majority of treatment takes the route of apoptotic induction. It is of great importance to develop an alternative strategy to induce cancer cell death. We previo
Autor:
Wei-jia Wang, Ying-ping Li, Peng-bo Yang, Qi-tao Chen, Yu Zheng, Qiao Wu, Hang-zi Chen, Jia-yuan Zhang, Xiao-yu Sun, Kun-Yi Chien, Fen-na Zhang, Xiaomin Wang, Sheng Zhang, Xue-li Bian, Wenxiu Zhao
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Gluconeogenesis, an essential metabolic process for hepatocytes, is downregulated in hepatocellular carcinoma (HCC). Here we show that the nuclear receptor Nur77 is a tumour suppressor for HCC that regulates gluconeogenesis. Low Nur77 expression in c
Autor:
Tianwei Lin, Qian Zhang, Xu-yang Tian, Feng-wei Li, An-zhong Li, Bo Zhou, Qiao Wu, Chen Ping, Hong-Kui Zhang, Rong Wu, Lu-ming Yao, Bi-xing Zhao, Xue-li Bian, Yan Chen, Friedrich Beermann, Jie Zhang, Wei-jia Wang, Jiahuai Han, Yong-zhen Xing, Li Li, Pei-Qiang Huang, Yuan Wang, Mian Wu, Yuan Liu, Hang-zi Chen, Yi Zhang
Publikováno v:
Nature chemical biology. 10(2)
Autophagy is linked to cell death, yet the associated mechanisms are largely undercharacterized. We discovered that melanoma, which is generally resistant to drug-induced apoptosis, can undergo autophagic cell death with the participation of orphan n