WW domain containing E3 ubiquitin protein ligase 1 (WWP1) negatively regulates TLR4-mediated TNF-α and IL-6 production by proteasomal degradation of TNF receptor associated factor 6 (TRAF6).

Autor: Xiao-Wen Lin, Wei-Cheng Xu, Jian-Gang Luo, Xue-Jiao Guo, Tao Sun, Xu-Li Zhao, Zhi-Jian Fu

Publikováno v: PLoS ONE, Vol 8, Iss 6, p e67633 (2013)

Toll-like receptors (TLRs) play a pivotal role in the defense against invading pathogens by detecting pathogen-associated molecular patterns (PAMPs). TLR4 recognizes lipopolysaccharides (LPS) in the cell walls of Gram-negative bacteria, resulting in

Externí odkaz: https://doaj.org/article/d0179db6118147a09d209d30748bdc36

A lipophilic prodrug of Danshensu: preparation, characterization, and in vitro and in vivo evaluation

Autor: Bin Qiao, Xue-Jiao Guo, Xue-Jiao Fan, Zhi-Qiang Ge

Publikováno v: Chinese Journal of Natural Medicines. 15:355-362

Danshensu [3-(3, 4-dihydroxyphenyl) lactic acid, DSS], one of the significant cardioprotective components, is extracted from the root of Salvia miltiorrhiza. In the present study, an ester prodrug of Danshensu (DSS), palmitoyl Danshensu (PDSS), was s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ede49eeb8492d93290d5bc2223ef983
https://doi.org/10.1016/s1875-5364(17)30056-0

Constructing Yeast Chimeric Pathways To Boost Lipophilic Terpene Synthesis

Autor: Hong Liu, Hao Qi, Ying-Jin Yuan, Xue-Jiao Guo, Jin-Lai Zhang, Bin Jia, Duo Liu

Publikováno v: ACS synthetic biology. 8(4)

Synthetic chimeric biological system offers opportunities to illuminate principles of designing life, and a primary step is constructing synthetic chimeric pathways. Here, we constructed yeast chimeric pathways by transferring the genes from Saccharo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47cbf46832bbc6d64ca89cd0a6c03395
https://pubmed.ncbi.nlm.nih.gov/30779549

'Perfect' designer chromosome V and behavior of a ring derivative

Autor: Ning Zhi Liu, Wen Zheng Zhang, Qiu Hui Lin, Ting Liu, Jing Sheng Cheng, Mei Qing Fu, Kun Yang, Ming Zhu Ding, Ran Tao, J. Andrew Martin, Yue Shen, Xia Li, Jef D. Boeke, Guo Zhen Jiang, Zhi Chao Yu, Si Chen, Wan Su, Jin Gui Liu, Jian Jun Qiao, Yan Wang, Shi Yang Liu, Wen Qian Zhang, Su Wang, Hang Xu, Shi Lei Han, Wei Liu, Ken Chen, Yi Wu, Yue Liu, Ze-Xiong Xie, Juan Zhao, Yi Lin Liu, Roy Walker, Li Xiang Song, Ye Xuan Deng, Xuya Wang, Xia Wang, Rui Guo, Leslie A. Mitchell, Joel S. Bader, Ting Ting Zhang, Ming Hua Shen, Guang Rong Zhao, Xiao Tong Wei, Xiao Ran Xu, Bing-Zhi Li, Jun Qi Zhu, Ying-Jin Yuan, Hao Xing Du, Bo Xuan Zeng, Yi Ran Wang, Bin Jia, Zheng Kuang, Shi Lan Yang, Ting Li, Lan Meng Qu, Jia Qing Zhu, Kai Ren Tian, Ping Sheng Ma, Tian Qing Song, Xue Nan Li, Guang Xin Ye, Cheng Hu, Huanming Yang, Jia Fei Lv, Wei Zhang, Yisha Luo, Qi Feng, Zhu Jin, Zhen Ning Liu, Wen Qi Ding, Fang Zhai, Xin Qi, Jin Hua Zhang, Xiao Le Wu, Yizhi Cai, Meng Zhao, Xue Jiao Guo, Xue Bai, Jun Jun Dai, Meng Long Hu, Fei Fei Li, Si Yu Xin, Xiao Na Yang, En Xu Wang, Giovanni Stracquadanio, Hui Min Liu, Lin Ting Wang, Chun-Ting Zhang, Zheng Bao Xia, Da Shuai Li, Yun Wang, Nan Jia

Publikováno v: Xie, Z-X, Li, B-Z, Mitchell, L A, Wu, Y, Qi, X, Jin, Z, Jia, B, Wang, X, Zeng, B-X, Liu, H-M, Wu, X-L, Feng, Q, Zhang, W-Q, Liu, W, Ding, M-Z, Li, X, Zhao, G-R, Qiao, J-J, Cheng, J-S, Zhao, M, Kuang, Z, Wang, X, Martin, J A, Stracquadanio, G, Yang, K, Bai, X, Zhao, J, Hu, M-L, Lin, Q-H, Zhang, W-Q, Shen, M-H, Chen, S, Su, W, Wang, E-X, Guo, R, Zhai, F, Guo, X-J, Du, H-X, Zhu, J-Q, Song, T-Q, Dai, J-J, Li, F-F, Jiang, G-Z, Han, S-L, Liu, S-Y, Yu, Z-C, Yang, X-N, Chen, K, Hu, C, Li, D-S, Jia, N, Liu, Y, Wang, L-T, Wang, S, Wei, X-T, Fu, M-Q, Qu, L-M, Xin, S-Y, Liu, T, Tian, K-R, Li, X-N, Zhang, J-H, Song, L-X, Liu, J-G, Lv, J-F, Xu, H, Tao, R, Wang, Y, Zhang, T-T, Deng, Y-X, Wang, Y-R, Li, T, Ye, G-X, Xu, X-R, Xia, Z-B, Zhang, W, Yang, S-L, Liu, Y-L, Ding, W-Q, Liu, Z-N, Zhu, J-Q, Liu, N-Z, Walker, R, Luo, Y, Wang, Y, Shen, Y, Yang, H, Cai, Y, Ma, P-S, Zhang, C-T, Bader, J S, Boeke, J D & Yuan, Y-J 2017, ' "Perfect" designer chromosome V and behavior of a ring derivative ', Science, vol. 355, no. 6329 . https://doi.org/10.1126/science.aaf4704

INTRODUCTION The Saccharomyces cerevisiae 2.0 project (Sc2.0) aims to modify the yeast genome with a series of densely spaced designer changes. Both a synthetic yeast chromosome arm (synIXR) and the entirely synthetic chromosome (synIII) function wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e38923b67576ca15f20973c8d990e9b6
https://doi.org/10.1126/science.aaf4704

WW domain containing E3 ubiquitin protein ligase 1 (WWP1) negatively regulates TLR4-mediated TNF-α and IL-6 production by proteasomal degradation of TNF receptor associated factor 6 (TRAF6)

Autor: Xu-Li Zhao, Jiangang Luo, Zhijian Fu, Xiaowen Lin, Tao Sun, Xue-Jiao Guo, Wei-Cheng Xu

Publikováno v: PLoS ONE, Vol 8, Iss 6, p e67633 (2013)
PLoS ONE

Background Toll-like receptors (TLRs) play a pivotal role in the defense against invading pathogens by detecting pathogen-associated molecular patterns (PAMPs). TLR4 recognizes lipopolysaccharides (LPS) in the cell walls of Gram-negative bacteria, re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b2b1f52ff2175ce9f12fac27c3447d4
http://europepmc.org/articles/PMC3684580?pdf=render