Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Xue-Feng Pei"'
Autor:
Tara H. Gupta, Yumika Kaneko, Richard W. Fitch, Xue-Feng Pei, Dan Shi, Irina Federova, John W. Daly
Publikováno v:
Bioorganic & Medicinal Chemistry. 12:179-190
Homoepiboxidine (3) and the corresponding N-methyl (4) and N-benzyl (5) derivatives were prepared from a 6β-carbomethoxynortropane (8). Affinities and functional activities at neuromuscular, central neuronal and ganglionic-type nicotinic receptors w
Autor:
Xue-Feng Pei, David G. Covell, John B. Ewell, Arnold Brossi, N Y Nguyen, Ruoli Bai, Ernest Hamel
Publikováno v:
Journal of Biological Chemistry. 275:40443-40452
2-Chloroacetyl-2-demethylthiocolchicine (2CTC) and 3-chloroacetyl-3-demethylthiocolchicine (3CTC) resemble colchicine in binding to tubulin and react covalently with beta-tubulin, forming adducts with cysteine residues 239 and 354. The adducts at Cys
Publikováno v:
Journal of Medicinal Chemistry. 43:2514-2522
A series of esters of 6beta-hydroxynortropane and the N-methyl analogue 6beta-tropanol were synthesized and screened versus binding of an antagonist (quinuclidinyl benzilate) and an agonist (oxotremorine-M) at sites on human m(1)-, m(2)-, m(3)-, and
Publikováno v:
Journal of Medicinal Chemistry. 41:2047-2055
A series of tropane derivatives, related in structure to baogongteng A (1), an alkaloid from a Chinese herb, were synthesized. 6beta-Acetoxynortropane (5) had weak affinity (Ki 22 microM) for central (M1) muscarinic receptors in a [3H]quinuclidinyl b
Publikováno v:
Journal of Medicinal Chemistry. 40:2895-2901
N(8)-Benzylesermethole (6) was prepared from 5-methoxytryptamine (1) in five steps. Resolution of compound 6 by dibenzoyl- and ditoluyltartaric acid provided enantiomers (-)- and (+)-7. After demethylation, reaction with isocyanates and catalytic deb
Autor:
Dorey Speer, Arnold Brossi, Namisha Patel, Nigel H. Greig, Xue-Feng Pei, Donald K. Ingram, Hiroyuki Ikari, Edward L. Spangler
Publikováno v:
NeuroReport. 6:481-484
A new generation of cholinesterase inhibitors is expected to overcome some limitations of the therapeutic use of anticholinesterases. Phenserine is a long-acting and selective inhibitor of acetylcholinesterase with a preferential brain uptake. We hav
Publikováno v:
Medicinal Research Reviews. 15:3-31
I . Historical Background . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11. Target of Physostigmine an oids: Cholinesterase Enzymes . . . . . . . . A. Localization and Function . . . . . . . . . . . . . . .
Publikováno v:
ChemInform. 25
Publikováno v:
ChemInform. 26
I . Historical Background . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11. Target of Physostigmine an oids: Cholinesterase Enzymes . . . . . . . . A. Localization and Function . . . . . . . . . . . . . . .
Publikováno v:
ChemInform. 26