Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Xue Y. Zhu"'
Autor:
Raviteja Bulusu, Nkafu B. Ndemazie, Esther K. Frimpong, Andriana Inkoom, Joy C. Okoro, Xue Y. Zhu
Publikováno v:
Cancer Research. 83:839-839
The purpose of the study is to characterize modified 5-FU (MFU) and investigate its anticancer activity in liposomal nanoparticles (MFU-Lnps) against colorectal and pancreatic cancer cell lines. Methods: The synthesized MFU was characterized by NMR a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0fb5898418244d866f2e1c80f745329
https://doi.org/10.1158/1538-7445.am2023-839
https://doi.org/10.1158/1538-7445.am2023-839
Autor:
Gladys Asong, Terrick Andey, Felix Amissah, Barbara A. Bricker, Xue Y. Zhu, Seth Y. Ablordeppey, Nazarius S. Lamango
Publikováno v:
Bioorg Med Chem
Our previous study has revealed 4-(4-(4-chlorophenyl)-1,4-diazepan-1-yl)-1-(4-fluorophenyl)butan-1-one·2HCl (SYA013) 1 as a sigma ligand with moderate selectivity for the sigma-2 receptor. Given the overexpression of sigma receptors in solid tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b92f52f1276b37ee25030be5ecfa32d8
https://doi.org/10.1016/j.bmc.2019.04.012
https://doi.org/10.1016/j.bmc.2019.04.012
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:2421-2426
Several lines of evidence suggest that selective sigma-2 (σ2) ligands might be useful for the treatment of solid tumors. However, very few selective σ2 ligands have been identified. This study was aimed at identifying new selective σ2 receptor lig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e6d76dceb3000191698bf98c8db3262
https://doi.org/10.1016/j.bmc.2019.01.035
https://doi.org/10.1016/j.bmc.2019.01.035
Publikováno v:
Cancer Research. 81:PO-047
Purpose: Pancreatic ductal adenocarcinoma (PDAC) is the most aggressive and scourging soft tissue tumor worldwide. Its current incidence is 13 per 100,000 US population with a very low 5-years survival rate (5%) and estimated to be the second leading
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b13f55175d5a44d1af7e3fb20281acd
https://doi.org/10.1158/1538-7445.panca21-po-047
https://doi.org/10.1158/1538-7445.panca21-po-047
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:5730-5740
Diseases of the CNS are often complex and involve multiple receptor systems and thus, the treatment options for these diseases must focus on targeting the multiple receptors implicated in the various disorders. Schizophrenia and depression are exampl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6aace01084defef0d91e64b1b1fb265
https://doi.org/10.1016/j.bmc.2016.09.019
https://doi.org/10.1016/j.bmc.2016.09.019
Autor:
Barbara A. Bricker, Edem K. Onyameh, Hye Jin Kang, Jagan R. Etukala, Xue Y. Zhu, Suresh Eyunni, Xi Ping Huang, Bryan L. Roth, Edward Ofori, Seth Y. Ablordeppey
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:3671-3679
Several known D2 pharmacophores have been explored as templates for identifying ligands with multiple binding affinities at dopamine and serotonin receptors considered as clinically relevant receptors in the treatment of neuropsychiatric diseases. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e79bcd639d59eb30bb9052da0a497ea
https://doi.org/10.1016/j.bmc.2016.06.011
https://doi.org/10.1016/j.bmc.2016.06.011
Publikováno v:
Bioorg Med Chem
Several lines of evidence suggest that selective sigma-2 (σ(2)) ligands might be useful for the treatment of solid tumors. However, very few selective σ(2) ligands have been identified. This study was aimed at identifying new selective σ(2) recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e730d7d0f92b24f2a94ad89d40f1b205
https://pubmed.ncbi.nlm.nih.gov/30737135
https://pubmed.ncbi.nlm.nih.gov/30737135
Autor:
Seth Y. Ablordeppey, Shabana I. Khan, Jagan R. Etukala, Xue Y. Zhu, Comfort A. Boateng, Melissa R. Jacob, Sidney Bolden, Suresh Eyunni
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:7194-7201
The 3-dimensional quantitative structure-activity relationship (3D-QSAR) molecular modeling technique or comparative molecular field analysis (CoMFA) has been used to design analogs of the natural product cryptolepine (1). Twenty-three compounds with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee84f966089a5bc69cb079299968c197
https://doi.org/10.1016/j.bmc.2013.08.043
https://doi.org/10.1016/j.bmc.2013.08.043
Autor:
Jagan R. Etukala, Kamanski R. Jordan, Xi Ping Huang, Hye Jin Kang, Adia A. Adkins, Seth Y. Ablordeppey, Kwakye Peprah, Edward Ofori, Bryan L. Roth, Barbara A. Bricker, Xue Y. Zhu
5-HT1A and 5-HT7 receptors have been at the center of discussions recently due in part to their major role in the etiology of major central nervous system diseases such as depression, sleep disorders, and schizophrenia. As part of our search to ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c78c2ce58495c6ce652aa44806197c4b
https://europepmc.org/articles/PMC5060005/
https://europepmc.org/articles/PMC5060005/
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:1291-1297
Using haloperidol as a scaffold, new agents were designed to investigate the structural contributions of various groups to binding at CNS receptors associated with atypical antipsychotic pharmacology. It is clear that each pharmacophoric group, the b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04668edaea2da7fdf7b5a56b1cd091b5
https://doi.org/10.1016/j.bmc.2011.12.019
https://doi.org/10.1016/j.bmc.2011.12.019