Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Xue Wei Meng"'
Autor:
Xue Wei Meng, Kevin L. Peterson, Haiming Dai, Paula Schneider, Sun-Hee Lee, Jin-San Zhang, Alexander Koenig, Steve Bronk, Daniel D. Billadeau, Gregory J. Gores, Scott H. Kaufmann
Publikováno v:
Journal of Biological Chemistry. 298:101980
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d7a57d1016845d91ccb0bb59e69585f
https://doi.org/10.1016/j.jbc.2022.101980
https://doi.org/10.1016/j.jbc.2022.101980
MLN4924 induces Noxa upregulation in acute myelogenous leukemia and synergizes with Bcl-2 inhibitors
Autor:
Allan D. Hess, Xue Wei Meng, Judith E. Karp, Scott H. Kaufmann, B D Smith, Paula A. Schneider, Katherine L. B. Knorr, Haiming Dai
Publikováno v:
Cell Death & Differentiation. 22:2133-2142
MLN4924 (pevonedistat), an inhibitor of the Nedd8 activating enzyme (NAE), has exhibited promising clinical activity in acute myelogenous leukemia (AML). Here we demonstrate that MLN4924 induces apoptosis in AML cell lines and clinical samples via a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f31d7efa72440eb3da7f11e20d491eb
https://doi.org/10.1038/cdd.2015.74
https://doi.org/10.1038/cdd.2015.74
Publikováno v:
Cell Death & Differentiation. 20:64-76
Phosphatidylserine (PS) exposure on the external leaflet of the plasma membrane is widely observed during apoptosis and forms the basis for the annexin V binding assay to detect apoptotic cell death. Current efforts to explain PS exposure focus on tw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc7daef832857e8bbdca37d55887db17
https://doi.org/10.1038/cdd.2012.93
https://doi.org/10.1038/cdd.2012.93
Autor:
Gregory J. Gores, Steve F. Bronk, Haiming Dai, Paula A. Schneider, Scott H. Kaufmann, Daniel D. Billadeau, Xue Wei Meng, Jin San Zhang, Alexander Koenig, Sun Hee Lee, Kevin L. Peterson
Publikováno v:
Journal of Biological Chemistry. 286:35823-35833
Previous studies have suggested that there are two signaling pathways leading from ligation of the Fas receptor to induction of apoptosis. Type I signaling involves Fas ligand-induced recruitment of large amounts of FADD (FAS-associated death domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72e370b6bda5b4c8c472066cab249268
https://doi.org/10.1074/jbc.m111.240432
https://doi.org/10.1074/jbc.m111.240432
Autor:
Gail J. Roboz, Paula A. Schneider, Scott H. Kaufmann, Ellen K. Ritchie, Steven D. Gore, Nga T. Dai, Karen S. Flatten, Son B. Le, Valerie Ironside, Timothy Talbott, Xue Wei Meng, Lawrence E. Morris, Mark J. Levis, Alex A. Adjei, David A. Loegering, B. Douglas Smith, Eric J. Feldman, Rebecca M. Ricklis, John J. Wright, Elizabeth Garrett-Mayer, Jacqueline Greer, Judith E. Karp
Publikováno v:
Blood. 113:4841-4852
The farnesyltransferase inhibitor tipifarnib exhibits modest activity against acute myelogenous leukemia. To build on these results, we examined the effect of combining tipifarnib with other agents. Tipifarnib inhibited signaling downstream of the fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b587d701d95192028c34cebf72e9829
https://doi.org/10.1182/blood-2008-08-172726
https://doi.org/10.1182/blood-2008-08-172726
Autor:
Paula A. Schneider, Nga T. Dai, Chunrong Yu, B. Douglas Smith, Haiming Dai, Sun Hee Lee, Scott H. Kaufmann, David A. Loegering, Karen S. Flatten, Judith E. Karp, Xue Wei Meng, Alex A. Adjei, Shaji Kumar
Publikováno v:
Journal of Biological Chemistry. 282:29831-29846
Previous studies have suggested that Mcl-1, an antiapoptotic Bcl-2 homolog that does not exhibit appreciable affinity for the caspase 8-generated C-terminal Bid fragment (tBid), diminishes sensitivity to tumor necrosis factor-alpha-related apoptosis-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea0e5a5c40826152f6b2d7c10f8ef1aa
https://doi.org/10.1074/jbc.m706110200
https://doi.org/10.1074/jbc.m706110200
Publikováno v:
Current Opinion in Cell Biology. 18:668-676
A common feature of cancer cells is their ability to evade apoptosis as a result of alterations that block cell death signaling pathways. The extensive research efforts that elucidated these signaling pathways over the past decade have set the stage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7e9fc12599944d3197eedcb48c5e3a2
https://doi.org/10.1016/j.ceb.2006.10.008
https://doi.org/10.1016/j.ceb.2006.10.008
Autor:
Scott H. Kaufmann, Joya Chandra, Judith E. Karp, Timothy Kottke, Steven D. Gore, Xue Wei Meng, Judy Sebolt-Leopold, Keri Van Becelaere, David A. Loegering
Publikováno v:
Journal of Biological Chemistry. 278:47326-47339
Because the MAPK pathway plays important roles in cell proliferation and inhibition of apoptosis, this pathway has emerged as a potential therapeutic target for solid tumors and leukemia. At the present time there is little information about activati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34745b13f5ddb4ac995ec640bc6a5887
https://doi.org/10.1074/jbc.m304793200
https://doi.org/10.1074/jbc.m304793200
Publikováno v:
Journal of Biological Chemistry. 277:3776-3783
Regulation of death receptor-mediated apoptosis is incompletely understood. Previous studies have demonstrated that phorbol 12-myristate 13-acetate (PMA), a protein kinase C activator, inhibits Fas (CD95)-mediated apoptosis in Jurkat (type II) cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::386a4233b78318cfd9ba5484db330264
https://doi.org/10.1074/jbc.m107218200
https://doi.org/10.1074/jbc.m107218200
Autor:
A A-M de Narvajas, Z. Deng, Marta Herreros-Villanueva, Scott H. Kaufmann, Xue Wei Meng, Alexander Koenig, J.-S. Zhang, Timothy S. Gomez, Luis Bujanda, Volker Ellenrieder, Xiucui Li, Daniel D. Billadeau
Publikováno v:
Addi. Archivo Digital para la Docencia y la Investigación
instname
Cell Death & Disease
instname
Cell Death & Disease
While TRAIL is a promising anticancer agent due to its ability to selectively induce apoptosis in neoplastic cells, many tumors, including pancreatic ductal adenocarcinoma (PDA), display intrinsic resistance, highlighting the need for TRAIL-sensitizi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f4a7fb02ddbdf54a8eeea562c21f599
http://hdl.handle.net/10810/17385
http://hdl.handle.net/10810/17385
