Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Xue Qing D. Wang"'
Autor:
Yibo Xue, Brian Meehan, Elizabeth Macdonald, Sriram Venneti, Xue Qing D. Wang, Leora Witkowski, Petar Jelinic, Tim Kong, Daniel Martinez, Geneviève Morin, Michelle Firlit, Atefeh Abedini, Radia M. Johnson, Regina Cencic, Jay Patibandla, Hongbo Chen, Andreas I. Papadakis, Aurelie Auguste, Iris de Rink, Ron M. Kerkhoven, Nicholas Bertos, Walter H. Gotlieb, Blaise A. Clarke, Alexandra Leary, Michael Witcher, Marie-Christine Guiot, Jerry Pelletier, Josée Dostie, Morag Park, Alexander R. Judkins, Ralf Hass, Douglas A. Levine, Janusz Rak, Barbara Vanderhyden, William D. Foulkes, Sidong Huang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is driven by SMARCA4 loss. Here the authors demonstrate that SCCOHT cells are highly sensitive to CDK4/6 inhibition and provide mechanistic insights, whereby this druggable vulnerability
Externí odkaz:
https://doaj.org/article/a9bfc57c02f44dfc91dacd68ff8a6a66
Autor:
Yibo Xue, Brian Meehan, Zheng Fu, Xue Qing D. Wang, Pierre Olivier Fiset, Ralf Rieker, Cameron Levins, Tim Kong, Xianbing Zhu, Geneviève Morin, Lashanda Skerritt, Esther Herpel, Sriram Venneti, Daniel Martinez, Alexander R. Judkins, Sungmi Jung, Sophie Camilleri-Broet, Anne V. Gonzalez, Marie-Christine Guiot, William W. Lockwood, Jonathan D. Spicer, Abbas Agaimy, William A. Pastor, Josée Dostie, Janusz Rak, William D. Foulkes, Sidong Huang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Non-small cell lung cancers with inactivating SMARCA4 mutations are currently undruggable. Here, the authors show that the absence of SMARCA4/2 reduces chromatin accessibility at the CCND1 locus, leading to a subsequent reduction in cyclin D1 express
Externí odkaz:
https://doaj.org/article/f919a450f672493c812a00c6c5045ab6
Publikováno v:
Cancer Research. 82:B017-B017
DNA methylation Canyons (DMCs) are genomic regions devoid of DNA methylation over 3.5kb in hematopoietic stem cells (HSCs). DMCs form ultra long-range interactions spanning decades of megabases specifically in HSCs. These ultra-long DMC interactions
Autor:
Anne V. Gonzalez, Sungmi Jung, William A. Pastor, Tim Kong, Cameron Levins, Lashanda Skerritt, Brian Meehan, Alexander R. Judkins, Marie-Christine Guiot, Daniel Martinez, Janusz Rak, Zheng Fu, Xianbing Zhu, Pierre Fiset, William W. Lockwood, William D. Foulkes, Xue Qing D. Wang, Sophie Camilleri-Broët, Geneviève Morin, Sriram Venneti, Ralf J. Rieker, Esther Herpel, Jonathan Spicer, Sidong Huang, Abbas Agaimy, Yibo Xue, Josée Dostie
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications
Tumor suppressor SMARCA4 (BRG1), a key SWI/SNF chromatin remodeling gene, is frequently inactivated in cancers and is not directly druggable. We recently uncovered that SMARCA4 loss in an ovarian cancer subtype causes cyclin D1 deficiency leading to
Autor:
Alexander R. Judkins, Jerry Pelletier, Sidong Huang, Regina Cencic, Ron M. Kerkhoven, Douglas A. Levine, Yibo Xue, William D. Foulkes, Morag Park, Barbara C. Vanderhyden, Radia M. Johnson, Nicholas Bertos, Janusz Rak, Alexandra Leary, Aurélie Auguste, Jay R. Patibandla, Leora Witkowski, Marie-Christine Guiot, Hongbo Chen, Michelle Firlit, Brian Meehan, Daniel Martinez, Xue Qing D. Wang, Tim Kong, Petar Jelinic, Blaise A. Clarke, Michael Witcher, Geneviève Morin, Josée Dostie, Andreas I. Papadakis, Sriram Venneti, Elizabeth Macdonald, Walter H. Gotlieb, Ralf Hass, Iris de Rink, Atefeh Abedini
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Inactivating mutations in SMARCA4 (BRG1), a key SWI/SNF chromatin remodelling gene, underlie small cell carcinoma of the ovary, hypercalcemic type (SCCOHT). To reveal its druggable vulnerabilities, we perform kinase-focused RNAi screens and uncover t