Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Xue Lin Kwang"'
Autor:
Nicholas Ching Wei Ho, Josephine Yu Yan Yap, Zixuan Zhao, Yunyun Wang, Kanishka Fernando, Constance H Li, Xue Lin Kwang, Hong Sheng Quah, Camille Arcinas, N. Gopalakrishna Iyer, Eliza Li Shan Fong
Publikováno v:
Advanced Science, Vol 11, Iss 20, Pp n/a-n/a (2024)
Abstract Recently mapped transcriptomic landscapes reveal the extent of heterogeneity in cancer‐associated fibroblasts (CAFs) beyond previously established single‐gene markers. Functional analyses of individual CAF subsets within the tumor microe
Externí odkaz:
https://doaj.org/article/29d702fb4fab4690857b4ee587c042cf
Autor:
Ankur Sharma, Elaine Yiqun Cao, Vibhor Kumar, Xiaoqian Zhang, Hui Sun Leong, Angeline Mei Lin Wong, Neeraja Ramakrishnan, Muhammad Hakimullah, Hui Min Vivian Teo, Fui Teen Chong, Shumei Chia, Matan Thangavelu Thangavelu, Xue Lin Kwang, Ruta Gupta, Jonathan R. Clark, Giridharan Periyasamy, N. Gopalakrishna Iyer, Ramanuj DasGupta
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Drug resistance is one of the major causes of cancer-related deaths. Here, the authors using single cell RNA-seq of oral squamous cell carcinoma patient samples pre- and post-cisplatin treatment show that phenotypically homogenous cell populations di
Externí odkaz:
https://doaj.org/article/4c8180ac64824e05a63db761c9056b3c
Autor:
Rahul Nahar, Weiwei Zhai, Tong Zhang, Angela Takano, Alexis J. Khng, Yin Yeng Lee, Xingliang Liu, Chong Hee Lim, Tina P. T. Koh, Zaw Win Aung, Tony Kiat Hon Lim, Lavanya Veeravalli, Ju Yuan, Audrey S. M. Teo, Cheryl X. Chan, Huay Mei Poh, Ivan M. L. Chua, Audrey Ann Liew, Dawn Ping Xi Lau, Xue Lin Kwang, Chee Keong Toh, Wan-Teck Lim, Bing Lim, Wai Leong Tam, Eng-Huat Tan, Axel M. Hillmer, Daniel S. W. Tan
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
EGFR mutant lung adenocarcinoma (LUAD) exhibit diverse clinical outcomes in response to targeted therapies. Here the authors show that these LUADs involve a complex genomic landscape with high intratumor heterogeneity, providing insights into the evo
Externí odkaz:
https://doaj.org/article/358b10958e814ff3ae9b2917b6e35d5b
Autor:
Matan Thangavelu Thangavelu, Hui Min Vivian Teo, Fui Teen Chong, Jonathan R. Clark, Ankur Sharma, Ruta Gupta, Muhammad Hakimullah, Giridharan Periyasamy, Vibhor Kumar, Elaine Yiqun Cao, Xue Lin Kwang, Neeraja Ramakrishnan, Hui Sun Leong, Shumei Chia, N. Gopalakrishna Iyer, Angeline Mei Lin Wong, Xiaoqian Zhang, Ramanuj DasGupta
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Chemo-resistance is one of the major causes of cancer-related deaths. Here we used single-cell transcriptomics to investigate divergent modes of chemo-resistance in tumor cells. We observed that higher degree of phenotypic intra-tumor heterogeneity (
Autor:
Neha Rohatgi, Hui-Sun Leong, Anders Jacobsen Skanderup, Stephen Qi Rong Wong, Giridharan Periyasamy, Matan Thangavelu Thangavelu, Judice Lie Yong Koh, Fui-Teen Chong, Xiaoqian Zhang, Ramanuj DasGupta, N. Gopalakrishna Iyer, Dawn Pingxi Lau, Daniel Shao Weng Tan, Jane Vin Chan, Xue-Lin Kwang, Joo-Leng Low, Shivaji Rikka
Publikováno v:
EBioMedicine
EBioMedicine, Vol 64, Iss, Pp 103220-(2021)
EBioMedicine, Vol 64, Iss, Pp 103220-(2021)
Background Overexpression of epidermal growth factor receptor (EGFR), and downstream pathway activation appears to be a common oncogenic driver in the majority of head and neck squamous cell cancers (HNSCCs); yet targeting EGFR for the treatment of H
Autor:
Axel M. Hillmer, Lavanya Veeravalli, Bing Lim, Tong Zhang, Chong Hee Lim, Huay Mei Poh, Rahul Nahar, Tony Kiat Hon Lim, Alexis Jiaying Khng, Yin Yeng Lee, Ju Yuan, Xue Lin Kwang, Daniel Shao-Weng Tan, Wai Leong Tam, Xingliang Liu, Wan-Teck Lim, Dawn Pingxi Lau, Audrey S.M. Teo, Eng Huat Tan, Tina P.T. Koh, Audrey Ann Liew, Zaw Win Aung, Weiwei Zhai, Cheryl Xueli Chan, Chee Keong Toh, Angela Takano, Ivan M. L. Chua
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications
Nature Communications
EGFR-mutant lung adenocarcinomas (LUAD) display diverse clinical trajectories and are characterized by rapid but short-lived responses to EGFR tyrosine kinase inhibitors (TKIs). Through sequencing of 79 spatially distinct regions from 16 early stage
Autor:
Joo-Leng Low, Dawn Pingxi Lau, Xiaoqian Zhang, Xue-Lin Kwang, Neha Rohatgi, Jane Vin Chan, Fui-Teen Chong, Stephen Qi Rong Wong, Hui-Sun Leong, Matan Thangavelu Thangavelu, Shivaji Rikka, Anders Martin Jacobsen Skanderup, Daniel Shao Weng Tan, Giridharan Periyasamy, Judice Lie Yong Koh, N Gopalakrishna Iyer, Ramanuj DasGupta
Publikováno v:
EBioMedicine, Vol 66, Iss, Pp 103297-(2021)
EBioMedicine
EBioMedicine
Overexpression of epidermal growth factor receptor (EGFR), and downstream pathway activation appears to be a common oncogenic driver in the majority of head and neck squamous cell cancers (HNSCCs); yet targeting EGFR for the treatment of HNSCC has me
Autor:
Patrick Tan, Giridharan Periyasamy, Matan Thangavelu Thangavelu, Judice L. Y. Koh, Hiang Khoon Tan, Shen Yon Toh, Daniel Shao-Weng Tan, Joo-Leng Low, Yan Su, Ankur Sharma, Thakshayeni Skanthakumar, Jacqueline S.G. Hwang, Alexander Lezhava, Iain Beehuat Tan, Hannes Hentze, Hui-Sun Leong, Shumei Chia, N. Gopalakrishna Iyer, Xue-Lin Kwang, Kok-Hing Lim, Xiaoqian Zhang, Ramanuj DasGupta, Siang Hui Choo, Fui-Teen Chong, Denis Bertrand
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Nature Communications
Nature Communications
Genomics-driven cancer therapeutics has gained prominence in personalized cancer treatment. However, its utility in indications lacking biomarker-driven treatment strategies remains limited. Here we present a “phenotype-driven precision-oncology”
Autor:
Tony Kiat Hon Lim, Amit Jain, Weiwei Zhai, Angela Takano, Wan-Teck Lim, Mei-Kim Ang, Yin Yeng Lee, Xue Lin Kwang, Daniel Shao-Weng Tan, Gek San Tan, Alvin Soon Tiong Lim, Wai Leong Tam, Chee Keong Toh, Sze Huey Tan, Eng Huat Tan, Perry J R Liew, G. Lai, T. Rajasekaran, Chow Wei Too, Bien Soo Tan, John K.C. Lim, Anantham Devanand, Ju Yuan, Rahul Nahar, Ravindran Kanesvaran, Axel M. Hillmer, Quan Sing Ng, B.H. Ong, Apoorva Gogna, Dawn P. Lau, Zaw Win Aung, N. Gopalakrishna Iyer, Tina P.T. Koh, Wan Ling Tan, Tse Hui Lim
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 37(11)
Purpose Mesenchymal epithelial transition factor ( MET) activation has been implicated as an oncogenic driver in epidermal growth factor receptor ( EGFR)–mutant non–small-cell lung cancer (NSCLC) and can mediate primary and secondary resistance t
Autor:
Oi Lian Kon, Nicholas B. Shannon, Ke Li, Gerald Tay, Yudong Chen, Hiang Khoon Tan, N. Gopalakrishna Iyer, Jacqueline S.G. Hwang, Daniel Shao-Weng Tan, Khee Chee Soo, Chin-Ann Johnny Ong, Sze Min Lek, Josephine Hendrikson, Tony Kiat Hon Lim, Fui Teen Chong, Qiu Xuan Tan, Mei Kim Ang, Hui Jun Lim, Natascha Putri, Hui Sun Leong, Kelvin K.N. Koh, Xue Lin Kwang, Thakshayeni Skanthakumar, Ngian Chye Tan, Wai Har Ng, Joey W. S. Tan
Publikováno v:
Oral Oncology. 111:105035
OBJECTIVES We have previously identified and validated a panel of molecular prognostic markers (ATP13A3, SSR3, and ANO1) for Head and Neck Squamous Cell Carcinoma (HNSCC). The aim of this study was to investigate the consequence of ATP13A3 dysregulat