Concordant inter-laboratory derived concentrations of ceramides in human plasma reference materials via authentic standards

Autor: Federico Torta, Nils Hoffmann, Bo Burla, Irina Alecu, Makoto Arita, Takeshi Bamba, Steffany A. L. Bennett, Justine Bertrand-Michel, Britta Brügger, Mónica P. Cala, Dolores Camacho-Muñoz, Antonio Checa, Michael Chen, Michaela Chocholoušková, Michelle Cinel, Emeline Chu-Van, Benoit Colsch, Cristina Coman, Lisa Connell, Bebiana C. Sousa, Alex M. Dickens, Maria Fedorova, Finnur Freyr Eiríksson, Hector Gallart-Ayala, Mohan Ghorasaini, Martin Giera, Xue Li Guan, Mark Haid, Thomas Hankemeier, Amy Harms, Marcus Höring, Michal Holčapek, Thorsten Hornemann, Chunxiu Hu, Andreas J. Hülsmeier, Kevin Huynh, Christina M. Jones, Julijana Ivanisevic, Yoshihiro Izumi, Harald C. Köfeler, Sin Man Lam, Mike Lange, Jong Cheol Lee, Gerhard Liebisch, Katrice Lippa, Andrea F. Lopez-Clavijo, Malena Manzi, Manuela R. Martinefski, Raviswamy G. H. Math, Satyajit Mayor, Peter J. Meikle, María Eugenia Monge, Myeong Hee Moon, Sneha Muralidharan, Anna Nicolaou, Thao Nguyen-Tran, Valerie B. O’Donnell, Matej Orešič, Arvind Ramanathan, Fabien Riols, Daisuke Saigusa, Tracey B. Schock, Heidi Schwartz-Zimmermann, Guanghou Shui, Madhulika Singh, Masatomo Takahashi, Margrét Thorsteinsdóttir, Noriyuki Tomiyasu, Anthony Tournadre, Hiroshi Tsugawa, Victoria J. Tyrrell, Grace van der Gugten, Michael O. Wakelam, Craig E. Wheelock, Denise Wolrab, Guowang Xu, Tianrun Xu, John A. Bowden, Kim Ekroos, Robert Ahrends, Markus R. Wenk

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Abstract In this community effort, we compare measurements between 34 laboratories from 19 countries, utilizing mixtures of labelled authentic synthetic standards, to quantify by mass spectrometry four clinically used ceramide species in the NIST (Na

Externí odkaz: https://doaj.org/article/e8653562ef70466097f27cb7fad363e8

The LIDPAD Mouse Model Captures the Multisystem Interactions and Extrahepatic Complications in MASLD

Autor: Zun Siong Low, Damien Chua, Hong Sheng Cheng, Rachel Tee, Wei Ren Tan, Christopher Ball, Norliza Binte Esmail Sahib, Ser Sue Ng, Jing Qu, Yingzi Liu, Haiyu Hong, Chaonong Cai, Nandini Chilagondanahalli Lakshmi Rao, Aileen Wee, Mark Dhinesh Muthiah, Zoë Bichler, Barbara Mickelson, Mei Suen Kong, Vanessa Shiyun Tay, Zhuang Yan, Jiapeng Chen, Aik Seng Ng, Yun Sheng Yip, Marcus Ivan Gerard Vos, Nicole Ashley Tan, Dao Liang Lim, Debbie Xiu En Lim, Manesh Chittezhath, Jadegoud Yaligar, Sanjay Kumar Verma, Harish Poptani, Xue Li Guan, Sambasivam Sendhil Velan, Yusuf Ali, Liang Li, Nguan Soon Tan, Walter Wahli

Publikováno v: Advanced Science, Vol 11, Iss 35, Pp n/a-n/a (2024)

Abstract Metabolic dysfunction‐associated steatotic liver disease (MASLD) represents an impending global health challenge. Current management strategies often face setbacks, emphasizing the need for preclinical models that faithfully mimic the huma

Externí odkaz: https://doaj.org/article/516eada6ebe94695a2023966be28ab43

Monocyte progenitors give rise to multinucleated giant cells

Autor: Anne Kathrin Lösslein, Florens Lohrmann, Lisa Scheuermann, Kourosh Gharun, Jana Neuber, Julia Kolter, Aaron James Forde, Christian Kleimeyer, Ying Yee Poh, Matthias Mack, Antigoni Triantafyllopoulou, Micah D. Dunlap, Shabaana A. Khader, Maximilian Seidl, Alexandra Hölscher, Christoph Hölscher, Xue Li Guan, Anca Dorhoi, Philipp Henneke

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)

Multinucleated giant cells characterize granuloma formation in mycobacterial infections. Here the authors identify monocyte precursors with distinct immunological and metabolic properties as a source of the granuloma multinucleated giant cell compart

Externí odkaz: https://doaj.org/article/b7de3fe7ad2f4ec7a67aa8fc0ad6eba6

Classical Activation of Macrophages Leads to Lipid Droplet Formation Without de novo Fatty Acid Synthesis

Autor: Mauricio Rosas-Ballina, Xue Li Guan, Alexander Schmidt, Dirk Bumann

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Altered lipid metabolism in macrophages is associated with various important inflammatory conditions. Although lipid metabolism is an important target for therapeutic intervention, the metabolic requirement involved in lipid accumulation during pro-i

Externí odkaz: https://doaj.org/article/321ec069674b4a23b5d6615ab65f87e2

Angiopoietin-like 4 shapes the intrahepatic T-cell landscape via eIF2α signaling during steatohepatitis in diet-induced NAFLD

Autor: Zun Siong Low, Damien Chua, Hong Sheng Cheng, Rachel Tee, Wei Ren Tan, Christopher Ball, Norliza Binte Esmail Sahib, Ser Sue Ng, Jing Qu, Yingzi Liu, Haiyu Hong, Chaonong Cai, Nandini C. L. Rao, Aileen Wee, Mark D. Muthiah, Zoë Bichler, Barbara Mickelson, Jia Qi Lee, Mei Suen Kong, Vanessa S.Y. Tay, Zhuang Yan, Jiapeng Chen, Aik Seng Ng, Yun Sheng Yip, Marcus Ivan Gerard Vos, Debbie Xiu En Lim, Manesh Chittezhath, Jadegoud Yaligar, Sanjay Kumar Verma, Harish Poptani, Xue Li Guan, S. Sendhil Velan, Yusuf Ali, Liang Li, Nguan Soon Tan, Walter Wahli

Adaptive T-cell immune response is essential in conferring protective immunity, a process requiring tight cellular homeostasis regulation. Pathological intrahepatic T-cell landscape has a role in NAFLD propagation; however, its activation remains unk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3fa97f1db42b4fa5bd0adf6381fb62d1
https://doi.org/10.1101/2023.01.10.523354