Výsledky vyhledávání - "Xue‐Jiao Leng"

Akademický článek

Preclinical characterization of danatinib as a novel FLT3 inhibitor with excellent efficacy against resistant acute myeloid leukemia

Publikováno v: Biomedicine & Pharmacotherapy, Vol 169, Iss , Pp 115905- (2023)

The therapeutic benefits of available FLT3 inhibitors for AML are limited by drug resistance, which is related to mutations, as well toxicity caused by off-target effects. In this study, we introduce a new small molecule FLT3 inhibitor called danatin

Externí odkaz: https://doaj.org/article/b4a16bb41b1041b8acc5195b558148af

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Discovery of 4‐(4‐aminophenyl)‐6‐phenylisoxazolo[3,4‐ b ]pyridine‐3‐amine derivatives as novel FLT3 covalent inhibitors for the intervention of acute myeloid leukemia

Publikováno v: Drug Development Research. 84:296-311

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6899df1c68e1c20799636d9816200ece
https://doi.org/10.1002/ddr.22032

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Design and synthesis of selective FLT3 inhibitors via exploration of back pocket II

Publikováno v: Future Medicinal Chemistry. 15:57-71

Aim: The clinical benefits of FLT3 inhibitors against acute myeloid leukemia (AML) have been limited by selectivity and resistance mutations. Thus, to identify FLT3 inhibitors possessing high selectivity and potency is of necessity. Methods & results

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4e2c6feedaad9225b8c2e4b4b234b20
https://doi.org/10.4155/fmc-2022-0231

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Scaffold-hopping of Linifanib to Design 6-Phenylisoxazolo[3,4-b]pyridin-3-amine Derivatives as FLT3 Inhibitors for Treating Acute Myeloid Leukemia

Publikováno v: Letters in Drug Design & Discovery. 20

Background: Acute myeloid leukemia (AML) is the most common type of blood cancer. Fms-like tyrosine kinase 3 (FLT3) is a member of the class III receptor tyrosine kinase family. Overexpression of FLT3 was found in 70-100% of patients with acute myelo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9250921b9447897024d7ae8b81f00588
https://doi.org/10.2174/1570180820666230519140242

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Synthesis and Biological Evaluation of 2-Amino-1-phenyl-benzimidazole Derivatives as BACE1 Inhibitors

Publikováno v: Letters in Drug Design & Discovery. 20

Background: Alzheimer’s disease (AD), a chronic neurodegenerative disorder predominantly occurs among the elderly, is the leading cause of dementia. The accumulation of β-amyloid (Aβ) is considered the main pathogenies of AD, and β-site APP-clea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::39196b9a437c00d50c0a0593f56125f8
https://doi.org/10.2174/1570180820666230223151850

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Comparative metabolites in plasma and urine of normal and type 2 diabetic rats after oral administration of the traditional Chinese scutellaria-coptis herb couple by ultra performance liquid chromatography-tandem mass spectrometry

Autor: Min Zhao, Dawei Qian, Shu Jiang, Jianming Guo, Erxin Shang, Jin-Ao Duan, Pei Liu, Xue-jiao Leng, Jun Xu, Leyue Du, Shulan Su

Publikováno v: Journal of Chromatography B. 965:27-32

Scutellaria-coptis herb couple is widely used traditional Chinese medicine (TCM) in treating type 2 diabetes; however, the in vivo integrated metabolism of its main bioactive components in type 2 diabetic rats remains unknown. In this paper, ultra-pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4f18387e2e8c0a354843a19b6d54978
https://doi.org/10.1016/j.jchromb.2014.05.028

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Identification of the metabolites of myricitrin produced by human intestinal bacteriain vitrousing ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry

Autor: Dawei Qian, Pei Liu, Su Shulan, Erxin Shang, Jun Xu, Leyue Du, Duan Jinao, Xue-jiao Leng, Shu Jiang, Min Zhao, Guo Jianming

Publikováno v: Expert Opinion on Drug Metabolism & Toxicology. 10:921-931

To investigate the metabolic routes and metabolites of myricitrin, an important active ingredient of traditional herbal medicine, yielded by the isolated human intestinal bacteria, which have not been reported previously.Fresh human fecal samples wer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::912315d6beaa1bddda82d069a2ced2f9
https://doi.org/10.1517/17425255.2014.918954

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Akademický článek

Autor: Shu Jiang¹ jiangshu2000@163.com, Jun Xu¹, Da-wei Qian¹, Er-xin Shang¹, Pei Liu¹, Shu-lan Su¹, Xue-jiao Leng¹, Jian-ming Guo¹, Jin-ao Duan¹ dja@njutcm.edu.cn, Leyue Du¹, Min Zhao¹

Publikováno v: Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences. Aug2014, Vol. 965, p27-32. 6p.

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