Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Xuchen Hu"'
Autor:
Linna Lu, Lingyu Wang, Wukang Shen, Shuai Fang, Lidong Zhao, Xuchen Hu, Linhua Yang, Gang Wang
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 11, Iss 5, Pp n/a-n/a (2023)
Abstract Background Hemophilia B (HB), a rare bleeding disorder, shows X‐linked recessive inheritance and is caused by heterogeneous variants in the FIX gene (F9) encoding coagulation factor IX (FIX). This study aimed to investigate the molecular p
Externí odkaz:
https://doaj.org/article/03ef4656e4e4417eb81fc58e6c95abbb
Autor:
Chenguang Niu, Ye Tu, Qiaoqiao Jin, Zhanyi Chen, Keyong Yuan, Min Wang, Pengfei Zhang, Junyuan Luo, Hao Li, Yueyi Yang, Xiaoyu Liu, Mengying Mao, Ting Dong, Wenduo Tan, Xuchen Hu, Yihuai Pan, Lili Hou, Rui Ma, Zhengwei Huang
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Metabolic dysfunction-associated fatty liver disease (MAFLD) is a phenotype of liver diseases associated with metabolic syndrome. The pathogenesis MAFLD remains unclear. The liver maintains is located near the intestine and is physiologically interde
Externí odkaz:
https://doaj.org/article/9b311998a14a4460ae6f5cc2b04a9c60
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-16 (2022)
Abstract Background Controlling the adipo-osteogenic lineage commitment of bone marrow mesenchymal stem cell (BMSC) in favor of osteogenesis is considered a promising approach for bone regeneration and repair. Accumulating evidence indicates that oxi
Externí odkaz:
https://doaj.org/article/618e0db723b041408e969e5e6531452e
Autor:
Wenwen Sun, Xuchen Hu, Lingyu Wang, Yanchun Ma, Xialin Zhang, Ruijuan Zhang, Lidong Zhao, Juan Ren, Linhua Yang, Gang Wang
Publikováno v:
Stem Cell Research, Vol 60, Iss , Pp 102682- (2022)
The lack of coagulation factor VIII in patient with nonsense mutation hemophilia A leads to varying degrees of bleeding symptoms, and long-term use of alternative therapies can produce inhibitors that affect the efficacy. In this study, human induced
Externí odkaz:
https://doaj.org/article/ddea1d0c266544188f283d0e1443f286
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The imbalance between bone formation and bone resorption causes osteoporosis, which leads to severe bone fractures. It is known that increases in osteoclast numbers and activities are the main reasons for increasing bone resorption. Although extensiv
Externí odkaz:
https://doaj.org/article/88aaefed3a2b467fa561c0d5901f24fe
Autor:
Wenzhen Lin, Li Gao, Wenxin Jiang, Chenguang Niu, Keyong Yuan, Xuchen Hu, Rui Ma, Zhengwei Huang
Publikováno v:
BMC Oral Health, Vol 19, Iss 1, Pp 1-8 (2019)
Abstract Background Extracellular matrix secretion and odontoblastic differentiation in human dental pulp stem cells (hDPSCs) are the cellular bases for reparative dentinogenesis. Osteomodulin (OMD) is a member of the small leucine-rich proteoglycan
Externí odkaz:
https://doaj.org/article/908ce8bbe3e44b47a72c7eb4fb4d90da
Autor:
Xuchen Hu, Mark W. Sleeman, Kazuya Miyashita, MacRae F. Linton, Christopher M. Allan, Cuiwen He, Mikael Larsson, Yiping Tu, Norma P. Sandoval, Rachel S. Jung, Alaleh Mapar, Tetsuo Machida, Masami Murakami, Katsuyuki Nakajima, Michael Ploug, Loren G. Fong, Stephen G. Young, Anne P. Beigneux
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 1, Pp 208-215 (2017)
GPIHBP1, an endothelial cell protein, binds LPL in the interstitial spaces and shuttles it to its site of action inside blood vessels. For years, studies of human GPIHBP1 have been hampered by an absence of useful antibodies. We reasoned that monoclo
Externí odkaz:
https://doaj.org/article/2cd466d9dd7b46b5858c18eb7905f80f
Autor:
Xuchen Hu, Thomas A Weston, Cuiwen He, Rachel S Jung, Patrick J Heizer, Brian D Young, Yiping Tu, Peter Tontonoz, James A Wohlschlegel, Haibo Jiang, Stephen G Young, Loren G Fong
Publikováno v:
eLife, Vol 8 (2019)
Cultured mouse peritoneal macrophages release large numbers of ~30-nm cholesterol-rich particles. Here, we show that those particles represent fragments of the plasma membrane that are pulled away and left behind during the projection and retraction
Externí odkaz:
https://doaj.org/article/c8058d365a7d44e2aede24f03b4dacae
Autor:
Xuchen Hu, Ken Matsumoto, Rachel S Jung, Thomas A Weston, Patrick J Heizer, Cuiwen He, Norma P Sandoval, Christopher M Allan, Yiping Tu, Harry V Vinters, Linda M Liau, Rochelle M Ellison, Jazmin E Morales, Lynn J Baufeld, Nicholas A Bayley, Liqun He, Christer Betsholtz, Anne P Beigneux, David A Nathanson, Holger Gerhardt, Stephen G Young, Loren G Fong, Haibo Jiang
Publikováno v:
eLife, Vol 8 (2019)
GPIHBP1, a GPI-anchored protein of capillary endothelial cells, binds lipoprotein lipase (LPL) within the subendothelial spaces and shuttles it to the capillary lumen. GPIHBP1-bound LPL is essential for the margination of triglyceride-rich lipoprotei
Externí odkaz:
https://doaj.org/article/c9e3de5bd1f74f16b0b5035d702b97d3
Autor:
Christopher M. Allan, Mikael Larsson, Xuchen Hu, Cuiwen He, Rachel S. Jung, Alaleh Mapar, Constance Voss, Kazuya Miyashita, Tetsuo Machida, Masami Murakami, Katsuyuki Nakajima, André Bensadoun, Michael Ploug, Loren G. Fong, Stephen G. Young, Anne P. Beigneux
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 10, Pp 1889-1898 (2016)
LPL contains two principal domains: an amino-terminal catalytic domain (residues 1–297) and a carboxyl-terminal domain (residues 298–448) that is important for binding lipids and binding glycosylphosphatidylinositol-anchored high density lipoprot
Externí odkaz:
https://doaj.org/article/ac99a4b067b747f9917164d4c2dcfb51