Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Xuanye Cao"'
Autor:
Xuanye Cao, Jianfeng Xu, Ying L. Lin, Robert M. Cabrera, Qiuying Chen, Chaofan Zhang, John W. Steele, Xiao Han, Steven S. Gross, Bogdan J. Wlodarczyk, James R. Lupski, Wei Li, Hongyan Wang, Richard H. Finnell, Yunping Lei
Publikováno v:
Cell Discovery, Vol 9, Iss 1, Pp 1-5 (2023)
Externí odkaz:
https://doaj.org/article/cac18d4dab7a40cb90efaf4b8f0c2cda
Autor:
Tian Tian, Xinyuan Lai, Kuanhui Xiang, Xiao Han, Shengju Yin, Robert M. Cabrera, John W. Steele, Yunping Lei, Xuanye Cao, Richard H. Finnell, Linlin Wang, Aiguo Ren
Publikováno v:
Epigenetics, Vol 17, Iss 2, Pp 133-146 (2022)
Neural tube defects (NTDs) are a group of common and severe congenital malformations. The PI3K-AKT signalling pathway plays a crucial role in the neural tube development. There is limited evidence concerning any possible association between aberrant
Externí odkaz:
https://doaj.org/article/b4ad165030fe41eeb2c7a7ef1707b370
Autor:
Abdel Rahman Abdel Fattah, Brian Daza, Gregorius Rustandi, Miguel Ángel Berrocal-Rubio, Benjamin Gorissen, Suresh Poovathingal, Kristofer Davie, Jorge Barrasa-Fano, Mar Cóndor, Xuanye Cao, Derek Hadar Rosenzweig, Yunping Lei, Richard Finnell, Catherine Verfaillie, Maurilio Sampaolesi, Peter Dedecker, Hans Van Oosterwyck, Stein Aerts, Adrian Ranga
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Mechanical forces, along with gene regulatory networks and cell-cell signalling, play an important role in the complex organization of tissues. Here the authors describe devices that actively apply mechanical force to developing neural tube, demonstr
Externí odkaz:
https://doaj.org/article/506e1172f48248a2922027f6f24d172b
Publikováno v:
Reproductive and Developmental Medicine, Vol 4, Iss 2, Pp 72-77 (2020)
Objective: The purpose of this study was to examine the role of rare variants in the one-carbon metabolic pathway in the etiology of the cerebral folate deficiency (CFD) syndrome. The CFD syndrome is a neurometabolic syndrome identified by low concen
Externí odkaz:
https://doaj.org/article/5ab37128d3664ca1b9c8d8367d4e9f5d
Autor:
Xiao Han, Xuanye Cao, Robert M. Cabrera, Paula Andrea Pimienta Ramirez, Cuilian Zhang, Vincent T. Ramaekers, Richard H. Finnell, Yunping Lei
Publikováno v:
Biology, Vol 12, Iss 1, p 74 (2022)
(1) Background: The genetic etiology of most patients with cerebral folate deficiency (CFD) remains poorly understood. KDM6B variants were reported to cause neurodevelopmental diseases; however, the association between KDM6B and CFD is unknown; (2) M
Externí odkaz:
https://doaj.org/article/96a3e0824dad41afaf523a1275d91bd3
Autor:
Sung-Eun Kim, Karla Robles-Lopez, Xuanye Cao, Kristyn Liu, Pooja J. Chothani, Nikitha Bhavani, Lauren Rahman, Saikat Mukhopadhyay, Bogdan J. Wlodarczyk, Richard H. Finnell
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Sonic hedgehog (Shh) signaling regulates multiple morphogenetic processes during embryonic neurogenesis and craniofacial skeletal development. Gpr161 is a known negative regulator of Shh signaling. Nullizygous Gpr161 mice are embryonic lethal, presen
Externí odkaz:
https://doaj.org/article/ecc5e70a6a5042ecb24eddb2d625d9c3
Autor:
Richard H. Finnell, Carlo Donato Caiaffa, Sung-Eun Kim, Yunping Lei, John Steele, Xuanye Cao, Gabriel Tukeman, Ying Linda Lin, Robert M. Cabrera, Bogdan J. Wlodarczyk
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Human structural congenital malformations are the leading cause of infant mortality in the United States. Estimates from the United States Center for Disease Control and Prevention (CDC) determine that close to 3% of all United States newborns presen
Externí odkaz:
https://doaj.org/article/c93c33257ec34a14be44dd25ec610947
Autor:
Tian Tian, Xuanye Cao, Yongyan Chen, Lei Jin, Zhiwen Li, Xiao Han, Ying Lin, Bogdan J. Wlodarczyk, Richard H. Finnell, Zhengwei Yuan, Linlin Wang, Aiguo Ren, Yunping Lei
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
BackgroundNeural tube defects (NTDs) are among the most common and severe congenital defects in humans. Their genetic etiology is complex and remains poorly understood. The Mediator complex (MED) plays a vital role in neural tube development in anima
Externí odkaz:
https://doaj.org/article/1f3c4fe37f1a4a6cbef24f54e1a82c68
Autor:
Zhongzhong Chen, Yunping Lei, Xuanye Cao, Yufang Zheng, Fang Wang, Yihua Bao, Rui Peng, Richard H. Finnell, Ting Zhang, Hongyan Wang
Publikováno v:
BMC Medical Genomics, Vol 11, Iss 1, Pp 1-9 (2018)
Abstract Background Mouse homozygous mutants in Wnt/planar cell polarity (PCP) pathway genes have been shown to cause neural tube defects (NTDs) through the disruption of normal morphogenetic processes critical to neural tube closure (NTC). Knockout
Externí odkaz:
https://doaj.org/article/f48163f5b49945be8f314ce200133e02
Autor:
Linlin Wang, Aiguo Ren, Tian Tian, Nan Li, Xuanye Cao, Peng Zhang, Lei Jin, Zhiwen Li, Yan Shen, Bo Zhang, Richard H. Finnell, Yunping Lei
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
BackgroundAnencephaly is a lethal neural tube defect (NTD). Although variants in several genes have been implicated in the development of anencephaly, a more complete picture of variants in the genome, especially de novo variants (DNVs), remains unre
Externí odkaz:
https://doaj.org/article/8942ef76107741349719995daa448c93