Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Xuanyao Liu"'
Autor:
Xuanyao Liu, Joel A. Mefford, Andrew Dahl, Yuan He, Meena Subramaniam, Alexis Battle, Alkes L. Price, Noah Zaitlen
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-14 (2020)
Abstract The observation that disease-associated genetic variants typically reside outside of exons has inspired widespread investigation into the genetic basis of transcriptional regulation. While associations between the mRNA abundance of a gene an
Externí odkaz:
https://doaj.org/article/97aec9537a544a67b0ff379b0fc4f860
Autor:
Fumihiko Takeuchi, Tomohiro Katsuya, Ryosuke Kimura, Toru Nabika, Minoru Isomura, Takayoshi Ohkubo, Yasuharu Tabara, Ken Yamamoto, Mitsuhiro Yokota, Xuanyao Liu, Woei-Yuh Saw, Dolikun Mamatyusupu, Wenjun Yang, Shuhua Xu, Japanese Genome Variation Consortium, Yik-Ying Teo, Norihiro Kato
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0185487 (2017)
The contemporary Japanese populations largely consist of three genetically distinct groups-Hondo, Ryukyu and Ainu. By principal-component analysis, while the three groups can be clearly separated, the Hondo people, comprising 99% of the Japanese, for
Externí odkaz:
https://doaj.org/article/a0c95a512d02403484900f36c0cc0695
Autor:
Lai-Ping Wong, Jason Kuan-Han Lai, Woei-Yuh Saw, Rick Twee-Hee Ong, Anthony Youzhi Cheng, Nisha Esakimuthu Pillai, Xuanyao Liu, Wenting Xu, Peng Chen, Jia-Nee Foo, Linda Wei-Lin Tan, Seok-Hwee Koo, Richie Soong, Markus Rene Wenk, Wei-Yen Lim, Chiea-Chuen Khor, Peter Little, Kee-Seng Chia, Yik-Ying Teo
Publikováno v:
PLoS Genetics, Vol 10, Iss 5, p e1004377 (2014)
South Asia possesses a significant amount of genetic diversity due to considerable intergroup differences in culture and language. There have been numerous reports on the genetic structure of Asian Indians, although these have mostly relied on genoty
Externí odkaz:
https://doaj.org/article/6b70d61ba9ab4cd6a6b016539874d966
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110974 (2014)
Body fat deposition and distribution differ between East Asians and Europeans, and for the same level of obesity, East Asians are at higher risks of Type 2 diabetes (T2D) and other metabolic disorders. This observation has prompted the reclassificati
Externí odkaz:
https://doaj.org/article/c1a96c5077a94123b693ac3a2c641698
Nearly all trait-associated variants identified in GWAS are non-coding. Thecisregulatory effects of these variants have been extensively characterized, but how they impact gene regulation intranshas been the subject of much fewer studies. Mappingtran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef985cc15906c8840c012dc75c28b288
https://doi.org/10.1101/2022.11.11.516189
https://doi.org/10.1101/2022.11.11.516189
Genome-wide association studies (GWAS) are overwhelmingly biased toward European ancestries. Nearly all existing studies agree that transferring genetic predictions from European ancestries to other populations results in a substantial loss of accura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e654117556e4565f8a8636bb72dea33
https://doi.org/10.1101/2022.10.21.22281371
https://doi.org/10.1101/2022.10.21.22281371
Autor:
Alka Singh, Nikita Babushkin, Michael Korzinkin, Viktoria Sarkisova, Vasudha Mishra, Ari Rosenberg, Mark Lingen, Justin Bishop, Alex Zhavoronkov, Nyall London, Nishant Agrawal, Xuanyao Liu, Evgeny Izumchenko
Publikováno v:
Cancer Research. 83:6077-6077
Approximately 50-80% of sinonasal tract cancers are sinonasal squamous cell carcinoma (SNSCC), a rare malignancy which occur in the nasal cavity and maxillary sinus. These lesions possess a propensity for local invasion into adjacent structures inclu
Autor:
Xuanyao Liu, Mefford, Joel A., Dahl, Andrew, He, Yuan, Subramaniam, Meena, Battle, Alexis, Alkes L. Price, Zaitlen, Noah
Additional file 1: Supplementary Tables and Figures. Tables S2. 90 trans-eGenes identified by SNP-based trans-eQTL mapping at 10% FDR. Table S3. Replication of trans signals in subsets of DGN. Table S4. Gene-ontology enrichment of 157 regulators iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18017125a290e56a3ae739be8a4792a3
Autor:
Xuanyao Liu, Mefford, Joel A., Dahl, Andrew, He, Yuan, Subramaniam, Meena, Battle, Alexis, Alkes L. Price, Zaitlen, Noah
Additional file 3. Review history
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38fac3320fa4534bf7bd6b65f93a4617
Annotations capturing cell type-specific TF binding explain a large fraction of disease heritability
Autor:
Alexander Gusev, Bryce van de Geijn, Yakir A. Reshef, Xuanyao Liu, Farhad Hormozdiari, Hilary K. Finucane, Steven Gazal, Tiffany Amariuta, Gleb Kichaev, Po-Ru Loh, Alkes L. Price, Soumya Raychauduri
Publikováno v:
Hum Mol Genet
Regulatory variation plays a major role in complex disease and that cell type-specific binding of transcription factors (TF) is critical to gene regulation. However, assessing the contribution of genetic variation in TF-binding sites to disease herit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c9fcfb6fdd73d7973f90f7b3e094ebd
https://europepmc.org/articles/PMC7206853/
https://europepmc.org/articles/PMC7206853/