Výsledky vyhledávání

The long persistence of pyrrolizidine alkaloid-derived pyrrole-protein adducts in vivo: Kinetic study following multiple exposures of a pyrrolizidine alkaloid containing extract of Gynura japonica

Autor: Changhong Wang, Aizhen Xiong, Li Yang, Fen Xiong, Weiqian Wang, Yan Chen, Gang Deng, Kaiyuan Jiang, Xuanling Ye, Zhengtao Wang

Publikováno v: Toxicology Letters. 323:41-47

Gynura japonica (also named Tusanqi in Chinese) is used as a folk herbal medicine for treating blood stasis or traumatic injury. However, hundreds of hepatic sinusoidal obstruction syndrome (HSOS) cases have been reported after consumption of prepara

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcc09da044404eea3193e438555d30e1
https://doi.org/10.1016/j.toxlet.2020.01.021

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A TMT-based shotgun proteomics uncovers overexpression of thrombospondin 1 as a contributor in pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome

Autor: Weiqian Wang, Yan Chen, Yue Yin, Xunjiang Wang, Xuanling Ye, Kaiyuan Jiang, Yi Zhang, Jiwei Zhang, Wei Zhang, Yuzheng Zhuge, Li Chen, Chao Peng, Aizhen Xiong, Li Yang, Zhengtao Wang

Publikováno v: Archives of toxicology. 96(7)

Hepatic sinusoidal obstruction disease (HSOS) is a rare but life-threatening vascular liver disease. However, its underlying mechanism and molecular changes in HSOS are largely unknown, thus greatly hindering the development of its effective treatmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b9ad1c47c5d1875165ac7405837f692
https://pubmed.ncbi.nlm.nih.gov/35357534

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Autor: Weiqian Wang, Xiao Yang, Yan Chen, Xuanling Ye, Kaiyuan Jiang, Aizhen Xiong, Li Yang, Zhengtao Wang

Publikováno v: Journal of Applied Toxicology. 40

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::657cb55ec3e56134bb5bd0c085bfb3fb
https://doi.org/10.1002/jat.3865

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Seneciphylline, a main pyrrolizidine alkaloid in Gynura japonica, induces hepatotoxicity in mice and primary hepatocytes via activating mitochondria-mediated apoptosis

Autor: Weiqian Wang, Li Yang, Zhengtao Wang, Kaiyuan Jiang, Xiao Yang, Yan Chen, Xuanling Ye, Aizhen Xiong

Publikováno v: Journal of applied toxicology : JATREFERENCES. 40(11)

Herbal drug-induced liver injury has been reported worldwide and gained global attention. Thousands of hepatic sinusoidal obstruction syndrome (HSOS) cases have been reported after consumption of herbal medicines and preparations containing pyrrolizi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b0db9edca9cb9d6a49d0ebd99ac8ab6
https://pubmed.ncbi.nlm.nih.gov/32618019

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