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Akademický článek

Microtubule asters anchored by FSD1 control axoneme assembly and ciliogenesis

Autor: Hai-Qing Tu, Xuan-He Qin, Zhi-Bin Liu, Zeng-Qing Song, Huai-Bin Hu, Yu-Cheng Zhang, Yan Chang, Min Wu, Yan Huang, Yun-Feng Bai, Guang Wang, Qiu-Ying Han, Ai-Ling Li, Tao Zhou, Feng Liu, Xue-Min Zhang, Hui-Yan Li

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)

Microtubule asters originate from centrosomes but their role during interphase remains largely unknown. Here, the authors find that microtubule asters anchored by previously-uncharacterized FSD1 play a role in ciliogenesis by maintaining the dynamic

Externí odkaz: https://doaj.org/article/11c8b38ba9bf4af5aa4846beb8f509dd

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Akademický článek

Signaling protein signature predicts clinical outcome of non-small-cell lung cancer

Publikováno v: BMC Cancer, Vol 18, Iss 1, Pp 1-12 (2018)

Abstract Background Non-small-cell lung cancer (NSCLC) is characterized by abnormalities of numerous signaling proteins that play pivotal roles in cancer development and progression. Many of these proteins have been reported to be correlated with cli

Externí odkaz: https://doaj.org/article/4c3796d5eb42404c84422808102b6129

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LUBAC regulates ciliogenesis by promoting CP110 removal from the mother centriole

Publikováno v: Journal of Cell Biology. 221

Primary cilia transduce diverse signals in embryonic development and adult tissues. Defective ciliogenesis results in a series of human disorders collectively known as ciliopathies. The CP110–CEP97 complex removal from the mother centriole is an ea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f16c7e03de68cc1e8caaf0ed5621357
https://doi.org/10.1083/jcb.202105092

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LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores

Autor: Guang Wang, Rui Mu, Duan Xiaotao, Qiu-Ying Han, Yu-Cheng Zhang, Hai-Qing Tu, Kazuhiro Iwai, Huai-Bin Hu, Li Huiyan, Xue-Min Zhang, Wei-Hua Li, Weina Zhang, Min Wu, Yan Chang, Tao Zhou, Ai-Ling Li, Xuan-He Qin

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications

Faithful chromosome segregation requires proper chromosome congression at prometaphase and dynamic maintenance of the aligned chromosomes at metaphase. Chromosome missegregation can result in aneuploidy, birth defects and cancer. The kinetochore-boun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2ccc3c52a998c10a525f2ba7ed474cf
http://link.springer.com/article/10.1038/s41467-018-08043-7

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Microtubule asters anchored by FSD1 control axoneme assembly and ciliogenesis

Autor: Yu-Cheng Zhang, Qiu-Ying Han, Ai-Ling Li, Min Wu, Yan Chang, Hui-Yan Li, Feng Liu, Tao Zhou, Hai-Qing Tu, Yan Huang, Huai-Bin Hu, Xuan-He Qin, Yun-Feng Bai, Guang Wang, Zhibin Liu, Xue-Min Zhang, Zeng-Qing Song

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Nature Communications

Defective ciliogenesis causes human developmental diseases termed ciliopathies. Microtubule (MT) asters originating from centrosomes in mitosis ensure the fidelity of cell division by positioning the spindle apparatus. However, the function of microt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4314de420fd6e764a0f12e8bb2d41dd
https://doaj.org/article/11c8b38ba9bf4af5aa4846beb8f509dd

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Signaling protein signature predicts clinical outcome of non-small-cell lung cancer

Publikováno v: BMC Cancer
BMC Cancer, Vol 18, Iss 1, Pp 1-12 (2018)

Background Non-small-cell lung cancer (NSCLC) is characterized by abnormalities of numerous signaling proteins that play pivotal roles in cancer development and progression. Many of these proteins have been reported to be correlated with clinical out

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bba186c83cf044cc273e95e2d0fab9e
https://pubmed.ncbi.nlm.nih.gov/29510676

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Ubiquitin-associated Domain-containing Ubiquitin Regulatory X (UBX) Protein UBXN1 Is a Negative Regulator of Nuclear Factor κB (NF-κB) Signaling*

Autor: Yan Chang, Min Wu, Xuan-He Qin, Yu-Cheng Zhang, Rui Mu, Bo Tan, Ai-Ling Li, Xue-Min Zhang, Sai-Sai Guo, Yu-Bo Wang, Hui-Yan Li, Tao Li, Wei-Hua Li, Hai-Qing Tu

Excessive nuclear factor κB (NF-κB) activation should be precisely controlled as it contributes to multiple immune and inflammatory diseases. However, the negative regulatory mechanisms of NF-κB activation still need to be elucidated. Various type

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b09977f0bba6ce85d892be8a148a340
https://europepmc.org/articles/PMC4400349/

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RNF4 negatively regulates NF-κB signaling by down-regulating TAB2

Autor: Yu-Cheng Zhang, Hui-Yan Li, Xue-Min Zhang, Ai-Ling Li, Sai-Sai Guo, Hai-Qing Tu, Yu-Bo Wang, Yan Chang, Wei-Hua Li, Rui Mu, Bo Tan, Xuan-He Qin, Min Wu, Tao Li

Publikováno v: FEBS Letters. (19):2850-2858

Most of NF-κB (nuclear factor kappa B) signaling molecules have various types of post-translational modifications. In this study, we focused on ubiquitination and designed a siRNA library including most ubiquitin-binding domains. With this library,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36fb30ff0fd79a50e9a1dc84e5321453

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Akademický článek

Ubiquitin-associated Domain-containing Ubiquitin Regulatory X (UBX) Protein UBXN1 Is a Negative Regulator of Nuclear Factor κB (NF-κB) Signaling.

Autor: Yu-Bo Wang¹, Bo Tan¹, Rui Mu¹, Yan Chang¹, Min Wu¹, Hai-Qing Tu¹, Yu-Cheng Zhang¹, Sai-Sai Guo¹, Xuan-He Qin¹, Tao Li¹, Wei-Hua Li¹, Ai-Ling Li¹, Xue-Min Zhang¹, Hui-Yan Li¹ hyli@ncba.ac.cn

Publikováno v: Journal of Biological Chemistry. 4/17/2015, Vol. 290 Issue 16, p10395-10405. 11p.

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