Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Xuan-Chuan Yu"'
Autor:
Simon D.P. Baugh, Praveen K. Pabba, Joseph Barbosa, Eric Coulter, Urvi Desai, Jason P. Gay, Suma Gopinathan, Qiang Han, Rajee Hari, S. David Kimball, Huy V. Nguyen, Chi-You Ni, David R. Powell, Arian Smith, Kristen M. Terranova, Alan Wilson, Xuan-Chuan Yu, Victoria K. Lombardo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:3836-3839
The synthesis, SAR, and in vivo activity of inhibitors of delta-5 desaturase are described. Ring-constraint of the initial series provided access to a variety of in vitro active chemotypes, from which the indazole was selected. Examples from the inda
Autor:
Cynthia Anne Fink, Michael Alan Green, Thomas H. Lanthorn, Alan Wilson, G. Greg Zipp, Xuan-Chuan Yu, Katerina V. Savelieva, Amr Nouraldeen, Joseph Barbosa, Kristen M. Terranova, S. David Kimball
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:3886-3890
The incidence of cognitive disorders such as Alzheimer's disease continues to increase unabated. While cures for such diseases have eluded investigators, progress is being made on alleviating certain symptoms of these diseases. Mouse knockouts of the
Autor:
Ziye Liu, Maricar Miranda, Xuan Chuan Yu, Nghi Nguyen, Kenneth G. Carson, Qingyun Liu, Shiv Patel, Jonathan C. Swaffield
Publikováno v:
SLAS Discovery. 15:72-79
Deoxycytidine kinase (dCK) phosphorylates deoxycytidine, deoxyguanosine, and deoxyadenosine and plays an important role in the salvage pathway of nucleoside metabolism. dCK is also required for the phosphorylation of several antiviral and anticancer
Autor:
E-Chiang Lee, Urvi Desai, Gennady Gololobov, Seokjoo Hong, Xiao Feng, Xuan-Chuan Yu, Jason Gay, Nat Wilganowski, Cuihua Gao, Ling-Ling Du, Joan Chen, Yi Hu, Sharon Zhao, Laura Kirkpatrick, Matthias Schneider, Brian P. Zambrowicz, Greg Landes, David R. Powell, William K. Sonnenburg
Publikováno v:
Journal of Biological Chemistry. 284:13735-13745
Angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) are secreted proteins that regulate triglyceride (TG) metabolism in part by inhibiting lipoprotein lipase (LPL). Recently, we showed that treatment of wild-type mice with monoclonal anti
Autor:
Eric Buxton, Arian Oldham, Nguyen Nghi, Thomas H. Lanthorn, Zhi-Cai Shi, Catherine Bomont, David T. Tran, Qingyun Liu, Shiv Patel, Xuan Chuan Yu, Wandong Zhang
Publikováno v:
Neuroscience Letters. 451:212-216
The mammalian proline transporter (PROT) is a high affinity Na(+)/Cl(-)-dependent transporter expressed in specific regions of the brain. It is homologous to other neurotransmitter transporters such as glycine, norepinephrine, serotonin, and dopamine
Publikováno v:
Journal of Biological Chemistry. 284:1419-1424
Two members of the angiopoietin-like family of proteins, ANGPTL3 and ANGPTL4, have been shown to play important roles in modulating lipoprotein metabolism in the body. Both proteins were found to suppress lipoprotein lipase (LPL) activity in vitro as
Autor:
Christian Barth, William Margolin, Sui. Lay, Peter L. Beech, Xuan Chuan Yu, Paul R. Fisher, Amelia. Savage, Ben R. Kiefel, Dale Hereld, Paul R. Gilson
Publikováno v:
Eukaryotic Cell. 2:1315-1326
In bacteria, the protein FtsZ is the principal component of a ring that constricts the cell at division. Though all mitochondria probably arose through a single, ancient bacterial endosymbiosis, the mitochondria of only certain protists appear to hav
Autor:
Chantal Monnier, G. Colé, William Margolin, Jean-Marc Valleton, Stéphane Alexandre, S. Coutard, Xuan-Chuan. Yu, Vic Norris
Publikováno v:
Colloids and Surfaces B: Biointerfaces. 23:391-395
FtsZ is the key protein in cell division in bacteria. We have proposed that lipid domains in the cytoplasmic membrane play a role in the localisation of FtsZ. In order to test this hypothesis, we used a model system based on Langmuir films to simulat
Publikováno v:
Europe PubMed Central
The site of cell division in Escherichia coli is defined by formation of the Z ring between the two segregated daughter nucleoids. Positioning of the Z ring, composed of the highly conserved and tubulin-like FtsZ protein, appears to be negatively reg
Autor:
William Margolin, Xuan Chuan Yu
Publikováno v:
Journal of Biological Chemistry. 273:10216-10222
To gain further insight into the structural relatedness of tubulin and FtsZ, the tubulin-like prokaryotic cell division protein, we tested the effect of tubulin assembly inhibitors on FtsZ assembly. Common tubulin inhibitors, such as colchicine, colc