Platelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice

Autor: Odette Leiter, David Brici, Stephen J. Fletcher, Xuan Ling Hilary Yong, Jocelyn Widagdo, Nicholas Matigian, Adam B. Schroer, Gregor Bieri, Daniel G. Blackmore, Perry F. Bartlett, Victor Anggono, Saul A. Villeda, Tara L. Walker

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)

Abstract The beneficial effects of physical activity on brain ageing are well recognised, with exerkines, factors that are secreted into the circulation in response to exercise, emerging as likely mediators of this response. However, the source and i

Externí odkaz: https://doaj.org/article/d8e83ff214284a649830da1f3c2ec9ee

Genome-Wide Association Study Suggests the Variant rs7551288*A within the DHCR24 Gene Is Associated with Poor Overall Survival in Melanoma Patients

Autor: Duffy, Annette Pflugfelder, Xuan Ling Hilary Yong, Kasturee Jagirdar, Thomas K. Eigentler, H. Peter Soyer, Richard A. Sturm, Lukas Flatz, David L.

Publikováno v: Cancers; Volume 14; Issue 10; Pages: 2410

Melanoma incidence rates are high among individuals with fair skin and multiple naevi. Established prognostic factors are tumour specific, and less is known about prognostic host factors. A total of 556 stage I to stage IV melanoma patients from Germ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::3c494774900b6ff813153c9498d537a4

Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIα phosphorylation of the GluN2A subunit

Autor: Joseph W. Lynch, Xiumin Chen, Katherine W. Roche, Marta Vieira, Liming Yang, Emma Livingstone, Mintu Chandra, Xiaojun Yu, Jing Zhi Anson Tan, Jocelyn Widagdo, Victor Anggono, Xuan Ling Hilary Yong, Angelo Keramidas, Brett M. Collins, Lingrui Zhang

NMDAR-dependent Ca2+ influx underpins multiple forms of synaptic plasticity. In the adult forebrain, the majority of synaptic NMDAR currents are mediated by GluN2A-containing NMDARs. These receptors are rapidly inserted into synapses during LTP; howe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c88be8e480bd8ad79c43ed3695755ac
https://doi.org/10.1101/2021.01.11.425709

Ubiquitination Regulates the Proteasomal Degradation and Nuclear Translocation of the Fat Mass and Obesity-Associated (FTO) Protein

Autor: Victor Anggono, Di Xia, Tianyi Zhu, Jocelyn Widagdo, Xuan Ling Hilary Yong

Publikováno v: Journal of Molecular Biology. 430:363-371

Genetic polymorphisms in the fat mass and obesity-associated (FTO) gene have been strongly associated with obesity in humans. The cellular level of FTO is tightly regulated, with alterations in its expression influencing energy metabolism, food intak

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c635887692c405bb938835d298fd9d7b
https://doi.org/10.1016/j.jmb.2017.12.003

PICK1 Controls Activity-Dependent Synaptic Vesicle Cargo Retrieval

Autor: Xuan Ling Hilary Yong, Victor Anggono, Michael A. Cousin

Publikováno v: Yong, X L H, Cousin, M A & Anggono, V 2020, ' PICK1 controls activity-dependent synaptic vesicle cargo retrieval ', Cell Reports . https://doi.org/10.1016/j.celrep.2020.108312

Efficient retrieval of synaptic vesicles (SVs) is crucial to sustain synaptic transmission. Protein interacting with C-kinase 1 (PICK1) is a unique PDZ (postsynaptic density-95/disc-large/zona-occluden-1)- and BAR (Bin-Amphiphysin-Rvs )-domain-contai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97a6d2ef6a038f2c992997894502e1f9
https://doi.org/10.1016/j.celrep.2020.108312