Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Xuan He Huang"'
Autor:
Wei Long, Bo-Xin Zheng, Ying Li, Xuan-He Huang, Dan-Min Lin, Cui-Cui Chen, Jin-Qiang Hou, Tian-Miao Ou, Wing-Leung Wong, Kun Zhang, Yu-Jing Lu
Publikováno v:
Nucleic Acids Research. 50:1829-1848
DNA G4-structures from human c-MYC promoter and telomere are considered as important drug targets; however, the developing of small-molecule-based fluorescent binding ligands that are highly selective in targeting these G4-structures over other types
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbd6775f06f0cb51c1153088a65bf06d
https://doi.org/10.1093/nar/gkac090
https://doi.org/10.1093/nar/gkac090
Autor:
Ao Lu Liu, Meng Ting She, Wing-Leung Wong, Xuan He Huang, Wei Long, Yu Jing Lu, Bo Xin Zheng, Kun Zhang
Publikováno v:
Journal of Medicinal Chemistry. 64:2125-2138
A series of fluorescent ligands, which were systematically constructed from thiazole orange scaffold, was investigated for their interactions with G-quadruplex structures and antitumor activity. Among the ligands, compound 3 was identified to exhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7072bcda4281468aee57374d93123cfe
https://doi.org/10.1021/acs.jmedchem.0c01656
https://doi.org/10.1021/acs.jmedchem.0c01656
Autor:
Yi‐Han Zhang, Xiao‐Chun Guo, Jia‐Ben Zhong, Dong‐Xiao Zhong, Xuan‐He Huang, Zhi‐Yuan Fang, Chi Zhang, Yu‐Jing Lu
Publikováno v:
ChemistrySelect. 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68f480a701ee847a63a9d5abeba3870d
https://doi.org/10.1002/slct.202201456
https://doi.org/10.1002/slct.202201456
Autor:
Xuan-He Huang, Meng-Ting She, Yi-Hang Zhang, Yi-Fu Liu, Dong-Xiao Zhong, Yi-Han Zhang, Jun-Xia Zheng, Ning Sun, Wing-Leung Wong, Yu-Jing Lu
Publikováno v:
Journal of applied microbiologyREFERENCES. 133(4)
Aims The emerging of drug resistant Pseudomonas aeruginosa is a critical challenge and renders an urgent action to discover innovative antimicrobial interventions. One of these interventions is to disrupt the pseudomonas quinolone signal (pqs) quorum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f18077cf737c4cf684e63eadcb874118
https://pubmed.ncbi.nlm.nih.gov/35490292
https://pubmed.ncbi.nlm.nih.gov/35490292
Antibacterial activity evaluation and mode of action study of novel thiazole-quinolinium derivatives
Autor:
Ying Li, Chen Cuicui, Wei Long, Hooi-Leng Ser, Xuan-He Huang, Ning Sun, Zhihua Liu, Yu-Jing Lu, Zheng Boxin, Yanan Li
Publikováno v:
RSC Advances. 10:15000-15014
New antimicrobial agents are urgently needed to address the emergence of multi-drug resistant organisms, especially those active compounds with new mechanisms of action. Based on the molecular structures of the FtsZ inhibitors reported, a variety of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f300d91cda153bb6626f2485fc89634f
https://doi.org/10.1039/d0ra00691b
https://doi.org/10.1039/d0ra00691b
Autor:
Yi-Han Zhang, Xuan-He Huang, Wing-Leung Wong, Jun-Ren Luo, Xiao-Chun Guo, Wenjie Liu, Jinqiang Hou, Meng-Ting She, Wen-Hao Jiang, Ning Sun, Yu-Jing Lu
Publikováno v:
Sensors and Actuators B: Chemical. 376:132992
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55cb3cb7a5a6247b018946d88aa7c59f
https://doi.org/10.1016/j.snb.2022.132992
https://doi.org/10.1016/j.snb.2022.132992
Akademický článek
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Autor:
Meng-Ting She, Jia-Wei Yang, Bo-Xin Zheng, Wei Long, Xuan-He Huang, Jun-Ren Luo, Ze-Xin Chen, Ao-Lu Liu, Dong-Peng Cai, Wing-Leung Wong, Yu-Jing Lu
Publikováno v:
Chemical Engineering Journal. 446:136947
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04985ea151276d4abdf92c045ef39c78
https://doi.org/10.1016/j.cej.2022.136947
https://doi.org/10.1016/j.cej.2022.136947
Autor:
Ziwei Tang, Wing-Leung Wong, Qi Guo, Ning Sun, Wenchang Yuan, Xuan-He Huang, Yu Jing Lu, Zhiyuan Fang, Sen-Yuan Cai, Hai Lin, Ying Li, Kwok Yin Wong
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:1274-1282
Filamenting temperature-sensitive mutant Z (FtsZ) is recognized as a promising target for new antibiotics development because of its high conservatism and pivotal role in the bacteria cell division. The aromatic heterocyclic scaffold of indole is kno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a044eda1d0c78be1fd157e33e772e53
https://doi.org/10.1016/j.bmc.2019.02.024
https://doi.org/10.1016/j.bmc.2019.02.024
Autor:
Dong-Xiao Zhong, Meng-Ting She, Xiao-Chun Guo, Bo-Xin Zheng, Xuan-He Huang, Yi-Han Zhang, Hooi-Leng Ser, Wing-Leung Wong, Ning Sun, Yu-Jing Lu
Publikováno v:
European Journal of Medicinal Chemistry. 236:114360
The discovery of small molecular inhibitors targeting essential and conserved bacterial drug targets such as FtsZ protein is a promising approach to fight against multi-drug resistant bacteria. In the present study, two new series of FtsZ inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b010c8de982f617756ca075285d77ee
https://doi.org/10.1016/j.ejmech.2022.114360
https://doi.org/10.1016/j.ejmech.2022.114360