Výsledky vyhledávání - "Xu-Guang Tai"

Reversible CD8 expression induced by common cytokine receptor γ chain-dependent cytokines in a cloned CD4+ Th1 cell line

Autor: Xuyu Zhou, Woong-Ryeon Park, Yi-Fu Yang, Michio Tomura, Hiromi Fujiwara, Yumi Yashiro-Ohtani, Xu-Guang Tai, Cheung-Seog Park, Toshiyuki Hamaoka, Kazuhito Toyo-oka

Publikováno v: International Immunology. 14:259-266

T cells that are intrathymically lineage committed are believed to maintain their CD4 or CD8 co-receptor expression. Here, we investigated whether intrathymic lineage commitment involves irreversible genetic modification or whether co-receptor expres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c415d8bf0b9974fe3aea02b515bfdf9
https://doi.org/10.1093/intimm/14.3.259

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CD5 Costimulation Up-Regulates the Signaling to Extracellular Signal-Regulated Kinase Activation in CD4+CD8+ Thymocytes and Supports Their Differentiation to the CD4 Lineage

Autor: Hiromi Fujiwara, Xuyu Zhou, Kazuhito Toyo-oka, Yumi Yashiro-Ohtani, Xu-Guang Tai, Toshiyuki Hamaoka, Cheung-Seog Park

Publikováno v: The Journal of Immunology. 164:1260-1268

CD5 positively costimulates TCR-stimulated mature T cells, whereas this molecule has been suggested to negatively regulate the activation of TCR-triggered thymocytes. We investigated the effect of CD5 costimulation on the differentiation of CD4+CD8+

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dd37dd8716d85092b41a41b957aa7d5
https://doi.org/10.4049/jimmunol.164.3.1260

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Association of a tetraspanin CD9 with CD5 on the T cell surface: role of particular transmembrane domains in the association

Autor: Toshiyuki Hamaoka, Xu-Guang Tai, Hiromi Fujiwara, Cheung-Seog Park, Yumi Yashiro-Ohtani, Kazuhito Toyo-oka, Kensuke Miyake

Publikováno v: International Immunology. 11:2043-2052

CD9 is a member of the tetraspanin superfamily which is characterized by four transmembrane (TM) domains and associates with other surface molecules. This tetraspanin was recently found to be expressed on mature T cells. Here, we investigated which m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b5b2072e3a62faea7d18bf81697263f
https://doi.org/10.1093/intimm/11.12.2043

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A caspase inhibitor protects thymocytes from diverse signal-mediated apoptosis but not from clonal deletion in fetal thymus organ culture

Autor: Hiromi Fujiwara, Yumi Yashiro, Toshiyuki Hamaoka, Cheung-Seog Park, Kazuhito Toyo-oka, Xu-Guang Tai

Publikováno v: Immunology Letters. 63:83-89

A family of caspases has been implicated as an effector in various forms of apoptosis. The present study investigated whether this family of proteases is involved in the induction of intrathymic clonal deletion in comparison with apoptosis induced in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b61b23fb3e2f8c9abebac055373c3562
https://doi.org/10.1016/s0165-2478(98)00059-5

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A fundamental difference in the capacity to induce proliferation of naive T cells between CD28 and other co-stimulatory molecules

Autor: Toshiyuki Hamaoka, Michiko Kobayashi, Hiromi Fujiwara, Yumi Yashiro, Ryo Abe, Kazuhito Toyo-oka, Xu-Guang Tai, Steven Neben, Cheung-Seog Park

Publikováno v: European Journal of Immunology. 28:926-935

T cell activation requires two signals: a signal from the TCR and a co-stimulatory signal provided by antigen-presenting cells (APC). In addition to CD28, multiple molecules on the T cell have been described to deliver co-stimulatory signals. Here, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c635b2e42cdc03c79fbb3de5d55d3d2
https://doi.org/10.1002/(sici)1521-4141(199803)28:03<926::aid-immu926>3.0.co

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SUPPRESSION OF ALLOGRAFT RESPONSES INDUCED BY INTERLEUKIN-6, WHICH SELECTIVELY MODULATES INTERFERON-?? BUT NOT INTERLEUKIN-2 PRODUCTION1

Autor: Hiromi Fujiwara, Xu-Guang Tai, Miho Murachi, Michio Tomura, Izumi Nakatani, Kazuhito Toyo-oka

Publikováno v: Transplantation. 64:757-763

BACKGROUND Interferon (IFN)-gamma produced by activated T cells represents an important effector cytokine in mediating an inflammatory response. METHODS The present study investigated the modulation of allograft responses by inhibiting IFN-gamma prod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aa07debf5476b78189bfbce7ba6ae812
https://doi.org/10.1097/00007890-199709150-00017

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Inhibition of Growth and Metastasis of Ovarian Carcinoma by Administering a Drug Capable of Interfering with Vascular Endothelial Growth Factor Activity

Autor: Norihiko Yamamoto, Xu-Guang Tai, Jie Mu, Hiroshi Terano, Tateki Tsutsui, Bunzo Sato, Ohtsura Niwa, Yoshiko Abe, Toshiyuki Hamaoka, Hiromi Fujiwara, Takahiro Tsujimura

Publikováno v: Japanese Journal of Cancer Research : Gann

The present study investigates the relationship between in vivo growth/metastasis of tumor cells and their capacity to produce the vascular endothelial growth factor (VEGF), as well as the regulation of tumor growth/metastasis using an angiogenesis-i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88c088da52a6d8dece57906364bc320e
https://doi.org/10.1111/j.1349-7006.1996.tb02127.x

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Molecular mechanisms underlying IFN-γ-mediated tumor growth inhibition induced during tumor growth inhibition induced during tumor immunotherapy with rIL-12

Autor: Hiromi Fujiwara, Hiroshi Takenaka, Wen-Gong Yu, Tateki Tsutsui, Ryotaro Yoshida, Rishani Wijesuriya, Noriniko Yamamoto, Jie Mu, Toshiyuki Hamaoka, Steven H. Herrmann, Xu-Guang Tai, Makoto Ogowa, Jian-Ping Zou

Publikováno v: International Immunology. 8:855-865

The present study investigates the molecular mechanisms by which IFN-gamma produced as a result of in vivo IL-12 administration exerts its anti-tumor effects. rIL-12 was administered three or five times into mice bearing CSA1M fibrosarcoma, OV-HM ova

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f52288b1608f67715028db6fb0b9696d
https://doi.org/10.1093/intimm/8.6.855

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A role for CD9 molecules in T cell activation

Autor: Andrew J. Long, J Morris, R Abe, Hiromi Fujiwara, Yumi Yashiro, Toshiyuki Hamaoka, Kazuhito Toyo-oka, Shiro Ono, Masayoshi Kobayashi, Xu-Guang Tai, S Neben, C R Wood

Publikováno v: The Journal of Experimental Medicine

Costimulation mediated by the CD28 molecule plays an important role in optimal activation of T cells. However, CD28-deficient mice can mount effective T cell-dependent immune responses, suggesting the existence of other costimulatory systems. In a se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1024237d1b85bccf3b7cf325dd5b2ba3
http://europepmc.org/articles/PMC2192734

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Non-CD28 costimulatory molecules present in T cell rafts induce T cell costimulation by enhancing the association of TCR with rafts

Autor: Hiromi Fujiwara, Kensuke Miyake, Cheung-Seog Park, Ryo Abe, Toshiyuki Hamaoka, Xuyu Zhou, Xu-Guang Tai, Kazuhito Toyo-oka, Yumi Yashiro-Ohtani

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 164(3)

While CD28 functions as the major T cell costimulatory receptor, a number of other T cell molecules have also been described to induce T cell costimulation. Here, we investigated the mechanisms by which costimulatory molecules other than CD28 contrib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eb6d3476355a5977116e9e914b01685
https://pubmed.ncbi.nlm.nih.gov/10640738

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