Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Xu-Gang Xia"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Background: Recessive mutation of the X-linked gene, PIH1 domain-containing protein 3 (PIH1D3), causes familial ciliopathy. PIH1D3 deficiency is associated with the defects of dynein arms in cilia, but how PIH1D3 specifically affects the structure an
Externí odkaz:
https://doaj.org/article/68e7cb02a65a43749cffe5614d2d6e72
Detergent-insoluble PFN1 inoculation expedites disease onset and progression in PFN1 transgenic rats
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Accumulating evidence suggests a gain of elusive toxicity in pathogenically mutated PFN1. The prominence of PFN1 aggregates as a pivotal pathological hallmark in PFN1 transgenic rats underscores the crucial involvement of protein aggregation in the i
Externí odkaz:
https://doaj.org/article/76fd476b1ec645b890fc961a2d3c7e4f
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 22, p 16214 (2023)
A dominant mutation in hnRNPA1 causes amyotrophic lateral sclerosis (ALS), but it is not known whether this mutation leads to motor neuron death through increased or decreased function. To elucidate the relationship between pathogenic hnRNPA1 mutatio
Externí odkaz:
https://doaj.org/article/9959ad069dce42dea3c2724443db0576
Publikováno v:
BioTechniques, Vol 41, Iss 1, Pp 64-68 (2006)
RNA interference (RNAi) has been increasingly used for reverse genetics. Both pol III and pol II promoters have been used to synthesize short hairpin RNA (shRNA) for knockdown of gene expression in mammalian cells and animals. Compared with gene knoc
Externí odkaz:
https://doaj.org/article/d1ace0ee0c3e4f8395d6b964f42e5ecf
Autor:
Cao Huang, Hongxia Zhou, Jianbin Tong, Han Chen, Yong-Jian Liu, Dian Wang, Xiaotao Wei, Xu-Gang Xia
Publikováno v:
PLoS Genetics, Vol 7, Iss 3, p e1002011 (2011)
Fused in Sarcoma (FUS) proteinopathy is a feature of frontotemporal lobar dementia (FTLD), and mutation of the fus gene segregates with FTLD and amyotrophic lateral sclerosis (ALS). To study the consequences of mutation in the fus gene, we created tr
Externí odkaz:
https://doaj.org/article/7e95254ff05a4b6f9b7dda9e5e7bc54c
Publikováno v:
PLoS Genetics, Vol 2, Iss 1, p e10 (2006)
RNA interference (RNAi) has been used increasingly for reverse genetics in invertebrates and mammalian cells, and has the potential to become an alternative to gene knockout technology in mammals. Thus far, only RNA polymerase III (Pol III)-expressed
Externí odkaz:
https://doaj.org/article/4284cec08fce4228add4819ce75aa1f1
Publikováno v:
Journal of Neurochemistry. 139:285-293
Pathogenic mutation of ubiquilin 2 (UBQLN2) causes neurodegeneration in amyotrophic lateral sclerosis and frontotemporal lobar degeneration. How UBQLN2 mutations cause the diseases is not clear. While over-expression of UBQLN2 with pathogenic mutatio
Autor:
Xu-Gang Xia, Cao Huang, Hongxia Zhou, Fangfang Bi, Linda H. Yan, Bo Huang, Jufang Huang, Jianbin Tong
Publikováno v:
Journal of Neurochemistry. 129:932-939
Mutation in TAR DNA binding protein 43 (TDP-43) is a causative factor of amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Neurodegeneration may not require the presence of pathogenic TDP-43 in all types of relevant cells. Rather,
Publikováno v:
International Journal of Biological Sciences
Environmental exposure, genetic modification, and aging are considered risky for Parkinson's disease (PD). How these risk factors cooperate to induce progressive neurodegeneration in PD remains largely unknown. Paraquat is an herbicide commonly used
Publikováno v:
International Journal of Biological Sciences, Vol 7, Iss 6, Pp 753-761 (2011)
Parkinson's disease (PD) results from progressive degeneration of dopaminergic neurons. Most PD cases are sporadic, but some have pathogenic mutation in the individual genes. Mutation of the leucine-rich repeat kinase-2 (LRRK2) gene is associated wit