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Extraction process optimization of Ligusticum chuanxiong hort. and its cardiomyocyte-protective effects via regulation of Dvl-1/Akt/GSK-3β/Nrf2

Autor: Ling-Yu Wang, Dan-Dan Tang, Ruo-Lan Li, Mei-Yan Li, Li-Sha He, Xu-Feng Pu, Shu-Ting Zhao

Publikováno v: Arabian Journal of Chemistry, Vol 17, Iss 8, Pp 105843- (2024)

Background: The traditional Chinese medicine Ligusticum chuanxiong Hort. (CHX) has been used in the management of heart disease, particularly myocardial ischemia (MI), but its related active constituents and mechanisms remain to be further explored.

Externí odkaz: https://doaj.org/article/e4bd9e2b0f784a8bb18cc7ccc3c7b818

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Anti-proliferation and anti-migration effects of an aqueous extract of Cinnamomi ramulus on MH7A rheumatoid arthritis-derived fibroblast-like synoviocytes through induction of apoptosis, cell arrest and suppression of matrix metalloproteinase

Autor: Jia Liu, Qing Zhang, Ruo-Lan Li, Shu-Jun Wei, Yong-Xiang Gao, Li Ai, Chun-Jie Wu, Xu-Feng Pu

Publikováno v: Pharmaceutical Biology, Vol 58, Iss 1, Pp 863-877 (2020)

Context Cinnamomi ramulus, the dry twig of Cinnamomum cassia Presl. (Lauraceae), has been reported to exert several activities such as antitumor, anti-inflammatory, and analgesic effects. Objective This study investigates the effects of an aqueous ex

Externí odkaz: https://doaj.org/article/e09b08a4b21243528f60003a37ed3493

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Akademický článek

Integrated network pharmacology analysis and in vitro cell experiments to reveal the mechanisms of Ligusticum chuanxiong Hort. in the treatment of non-alcoholic fatty liver disease.

Autor: Ling-Yu Wang, Cheng-Xun He, Dan-Dan Tang, Chun-Jie Wu, Shu-Ting Zhao, Xu-Feng Pu

Publikováno v: TMR Integrative Medicine; 2023, Vol. 7, p1-15, 15p

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Study of forced degradation behavior of pramlintide acetate by HPLC and LC-MS

Autor: Zheng-Fu Tai, Xu-Feng Pu, Gao Jian, Yi-Peng Xie, Yu Yuan, Yuan-Bo Li

Publikováno v: Journal of Food and Drug Analysis, Vol 26, Iss 1, Pp 409-415 (2018)

Pramlintide acetate (Symlin ® ), a synthetic analogue of the human hormone amylin. It was approved in March 2005 as a subcutaneous injection for the adjunctive treatment of patients who have type 1 or 2 diabetes mellitus. The objective of current in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c3d62ee827d93bca3d272c3fcad50d9
https://pubmed.ncbi.nlm.nih.gov/29389581

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Chemical constituents from Cimicifuga foetida

Autor: Xiao-Rong Zhang, Shu-Lin Peng, Pei Cao, Li-Sheng Ding, Xu-Feng Pu

Publikováno v: Journal of Asian natural products research. 7(2)

From the rhizoma of Cimicifuga foetida L. (Ranunculaceae) a new chromone, 6'-hydroxylangelicain (18), has been isolated together with 20 known compounds. The structure of 18 has been elucidated on the basis of spectroscopic and chemical evidence.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::687eb68d2e4afd226ecc692339a3bd25
https://pubmed.ncbi.nlm.nih.gov/15621617

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Foetidinol, a new trinor-triterpenoid with a novel carbon skeleton, from a Chinese crude drug 'Shengma' (Cimicifuga foetida L.)

Autor: Shigetoshi Kadota, Xu Feng Pu, Jian-Xin Li, Tsuneo Namba

Publikováno v: Tetrahedron Letters. 35:4575-4576

Foetidinol (1a), trinor-triterpenoid with a novel carbon skeleton, has been isolated from the rhizoma of Cimicifuga foetida L., and its structure was determined based on the 2D NMR spectroscopy including HMBC.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a8acec8a5f320d6217a892ec9d5cc09
https://doi.org/10.1016/s0040-4039(00)60732-3

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