Zobrazeno 1 - 10 of 52 pro vyhledávání: '"Xu-Dong Kong"'
1
Akademický článek
Towards the Development of Orally Available Peptide Therapeutics
Autor: Xu-Dong Kong, Christian Heinis
Publikováno v: CHIMIA, Vol 75, Iss 6, Pp 514-517 (2021)
Peptides have a number of attractive properties that make them an interesting modality for drug development, including their ability to bind challenging targets, their high target specificity, and their non-toxic metabolic products. However, a major
Externí odkaz: https://doaj.org/article/a52d8b221ac14bfbb6f1831a21bbc5ef
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2
Akademický článek
A minimalistic cyclic ice-binding peptide from phage display
Autor: Corey A. Stevens, Fabienne Bachtiger, Xu-Dong Kong, Luciano A. Abriata, Gabriele C. Sosso, Matthew I. Gibson, Harm-Anton Klok
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Developing molecules that emulate the properties of naturally occurring ice-binding proteins (IBPs) is a daunting challenge. Here, the authors demonstrate the use of phage display for the identification of short peptide mimics of IBPs, which resulted
Externí odkaz: https://doaj.org/article/21547cda4f1a4a8ab88ce626361f17f5
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3
Akademický článek
Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs
Autor: Jonas Wilbs, Xu-Dong Kong, Simon J. Middendorp, Raja Prince, Alida Cooke, Caitlin T. Demarest, Mai M. Abdelhafez, Kalliope Roberts, Nao Umei, Patrick Gonschorek, Christina Lamers, Kaycie Deyle, Robert Rieben, Keith E. Cook, Anne Angelillo-Scherrer, Christian Heinis
Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Inhibiting thrombosis without inducing bleeding is a major challenge for anticoagulant agents. Here the authors describe a synthetic FXIIa inhibitor able to efficiently prevent thrombosis in mice and suppress coagulation in artificial lungs in rabbit
Externí odkaz: https://doaj.org/article/1f9ddb75be1e4a398c1ff63698dcaa1b
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8
Generation of a Large Peptide Phage Display Library by Self-Ligation of Whole-Plasmid PCR Product
Autor: Vanessa Carle, Christian Heinis, Cristina Díaz-Perlas, Kaycie Butler, Xu-Dong Kong
Publikováno v: ACS Chemical Biology. 15:2907-2915
The success of phage display, used for developing target-specific binders based on peptides and proteins, depends on the size and diversity of the library screened, but generating large libraries of phage-encoded polypeptides remains challenging. New
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f2ef9ab3273d76c7c301aa600b0da24
https://doi.org/10.1021/acschembio.0c00497
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10
Interlaboratory analysis of teicoplanin plasma concentration assays among Chinese laboratories
Autor: Wenqian Chen, Wei Qin, Pengmei Li, Xianglin Zhang, Xu‐Dong Kong, Wang-Jun Qin, Shuo Xu, Peng‐Fei Jin, Xiaoxue Wang
Publikováno v: Journal of Clinical Pharmacy and Therapeutics. 45:983-990
What is known and objective Teicoplanin is widely used for the treatment of infections caused by drug-resistant Gram-positive bacteria. Since there is a good correlation between trough levels and clinical outcome, therapeutic drug monitoring (TDM) is
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2bf99d091328b1b45f9a2522b4fe73
https://doi.org/10.1111/jcpt.13115
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