Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Xu-Bin Bao"'
Autor:
Li‐Min Wang, Pingyuan Wang, Xiao‐Min Chen, Hui Yang, Shan‐Shan Song, Zilan Song, Li Jia, Hua‐Dong Chen, Xu‐Bin Bao, Ne Guo, Xia‐Juan Huan, Yong Xi, Yan‐Yan Shen, Xin‐Ying Yang, Yi Su, Yi‐Ming Sun, Ying‐Lei Gao, Yi Chen, Jian Ding, Jing‐Yu Lang, Ze‐Hong Miao, Ao Zhang, Jin‐Xue He
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 3, Pp n/a-n/a (2023)
Abstract Poly‐ADP‐ribose polymerase (PARP) inhibitors (PARPi) have shown great promise for treating BRCA‐deficient tumors. However, over 40% of BRCA‐deficient patients fail to respond to PARPi. Here, we report that thioparib, a next‐generat
Externí odkaz:
https://doaj.org/article/24325773452c46108ba801e5debd9f21
Autor:
Li-Na Zhou, Chaodong Xiong, Yong-Jun Cheng, Shan-Shan Song, Xu-Bin Bao, Xia-Juan Huan, Tong-Yan Wang, Ao Zhang, Ze-Hong Miao, Jin-Xue He
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 32, Iss , Pp 100823- (2022)
Inhibition of the NEDD8-activating enzyme (NAE), the key E1 enzyme in the neddylation cascade, has been considered an attractive anticancer strategy with the discovery of the first-in-class NAE inhibitor, MLN4924. In this study, we identified SOMCL-1
Externí odkaz:
https://doaj.org/article/b631d181d8ac4e6eaba5e0c1b074aaac
Autor:
Ning Zhang, Yu-Nan Tian, Li-Na Zhou, Meng-Zhu Li, Hua-Dong Chen, Shan-Shan Song, Xia-Juan Huan, Xu-Bin Bao, Ao Zhang, Ze-Hong Miao, Jin-Xue He
Publikováno v:
Cell Death and Disease, Vol 12, Iss 2, Pp 1-18 (2021)
Abstract Monotherapy with poly ADP-ribose polymerase (PARP) inhibitors results in a limited objective response rate (≤60% in most cases) in patients with homologous recombination repair (HRR)-deficient cancer, which suggests a high rate of resistan
Externí odkaz:
https://doaj.org/article/aa58f0bfd0a740678bf052d1f92375c9
Autor:
Li‐Min Wang, Pingyuan Wang, Xiao‐Min Chen, Hui Yang, Shan‐Shan Song, Zilan Song, Li Jia, Hua‐Dong Chen, Xu‐Bin Bao, Ne Guo, Xia‐Juan Huan, Yong Xi, Yan‐Yan Shen, Xin‐Ying Yang, Yi Su, Yi‐Ming Sun, Ying‐Lei Gao, Yi Chen, Jian Ding, Jing‐Yu Lang, Ze‐Hong Miao, Ao Zhang, Jin‐Xue He
Publikováno v:
EMBO Molecular Medicine. 15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3367cfcc4bca331ca0e997a18e1755eb
https://doi.org/10.15252/emmm.202216235
https://doi.org/10.15252/emmm.202216235
Autor:
Huaqian Ding, Jing Tan, Xu-Bin Bao, Shanshan Song, Jiannan Zhao, Ning Zhang, Jin-Xue He, Chaodong Xiong, Ze-Hong Miao, Ao Zhang, Li-Na Zhou
Publikováno v:
Journal of Medicinal Chemistry. 64:6161-6178
The ubiquitin-like protein NEDD8 is a critical signaling molecule implicated in the functional maintenance and homeostasis of cells. Dysregulation of this process is involved in a variety of human diseases, including cancer. Therefore, NEDD8-activati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::194bb6174cee128b96ab393d959c3a17
https://doi.org/10.1021/acs.jmedchem.1c00242
https://doi.org/10.1021/acs.jmedchem.1c00242
Publikováno v:
Am J Cancer Res
Colorectal cancer (CRC) is an aggressive malignancy with limited options for treatment. Targeting the bromodomain and extra terminal domain (BET) proteins by using BET inhibitors (BETis) could effectively interrupt the interaction with acetylated his
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::772e4c067484351fae378b33aed88bc1
https://pubmed.ncbi.nlm.nih.gov/35411247
https://pubmed.ncbi.nlm.nih.gov/35411247
Autor:
Hua-Dong Chen, Jin-Xue He, Xu-Bin Bao, Meng-Zhu Li, Huan Xiajuan, Ze-Hong Miao, Ning Zhang, Ao Zhang, Yu-Nan Tian, Li-Na Zhou, Shanshan Song
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 2, Pp 1-18 (2021)
Cell Death and Disease, Vol 12, Iss 2, Pp 1-18 (2021)
Monotherapy with poly ADP-ribose polymerase (PARP) inhibitors results in a limited objective response rate (≤60% in most cases) in patients with homologous recombination repair (HRR)-deficient cancer, which suggests a high rate of resistance in thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7efb8d21c6a0cf7895bf49ad4b74dc88
https://doi.org/10.1038/s41419-021-03475-4
https://doi.org/10.1038/s41419-021-03475-4
Autor:
Yongliang Zhang, Lanping Ma, Shanshan Song, Ze-Hong Miao, Ting Yu, Ning Zhang, Jingkang Shen, Bing Xiong, Xu-Bin Bao, Tao Meng, Jin-Xue He, Meng-Zhu Li
Publikováno v:
Investigational new drugs. 39(5)
G-quadruplexes (G4s) are DNA or RNA structures formed by guanine-rich repeating sequences. Recently, G4s have become a highly attractive therapeutic target for BRCA-deficient cancers. Here, we show that a substituted quinolone amide compound, MTR-106
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::371fe7ad0a09e772442504ea1461a377
https://pubmed.ncbi.nlm.nih.gov/33710464
https://pubmed.ncbi.nlm.nih.gov/33710464
Autor:
Chang-Qing Tian, Huan Xiajuan, Danqi Chen, Ze-Hong Miao, Bing Xiong, Qian Wu, Xu-Bin Bao, Jianping Hu, Kaikai Lv, Ying-Qing Wang, Lin Sun
Publikováno v:
Biochemical Pharmacology. 185:114435
Bromodomain and extra-terminal domain (BET) family proteins are promising anticancer targets. Most BET inhibitors in clinical trials are monovalent. They competitively bind to one of the bromodomains (BD1 and BD2) in BET proteins and exhibit relative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc913be3d49705575c7ea7151c9919ad
https://doi.org/10.1016/j.bcp.2021.114435
https://doi.org/10.1016/j.bcp.2021.114435