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Akademický článek

Widespread aggregation of mutant VAPB associated with ALS does not cause motor neuron degeneration or modulate mutant SOD1 aggregation and toxicity in mice

Autor: Qiu Linghua, Qiao Tao, Beers Melissa, Tan Weijia, Wang Hongyan, Yang Bin, Xu Zuoshang

Publikováno v: Molecular Neurodegeneration, Vol 8, Iss 1, p 1 (2013)

Abstract Background A proline-to-serine substitution at position-56 (P56S) of vesicle-associated membrane protein-associated protein B (VAPB) causes a form of dominantly inherited motor neuron disease (MND), including typical and atypical amyotrophic

Externí odkaz: https://doaj.org/article/e1fdb7e04aaf4f1dbe1d7dadeaa04a96

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Akademický článek

A construct with fluorescent indicators for conditional expression of miRNA

Autor: Xia Xugang, Wang Hongyan, Qiu Linghua, Zhou Hongxia, Xu Zuoshang

Publikováno v: BMC Biotechnology, Vol 8, Iss 1, p 77 (2008)

Abstract Background Transgenic RNAi holds promise as a simple, low-cost, and fast method for reverse genetics in mammals. It may be particularly useful for producing animal models for hypomorphic gene function. Inducible RNAi that permits spatially a

Externí odkaz: https://doaj.org/article/133076bd1b4a4345a4a91af149ca020c

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Akademický článek

ALS-associated mutant SOD1G93A causes mitochondrial vacuolation by expansion of the intermembrane space and by involvement of SOD1 aggregation and peroxisomes

Autor: Xu Zuoshang, Jung Cheolwha, Higgins Cynthia MJ

Publikováno v: BMC Neuroscience, Vol 4, Iss 1, p 16 (2003)

Abstract Background Amyotrophic lateral sclerosis (ALS) is an age-dependent neurodegenerative disease that causes motor neuron degeneration, paralysis and death. Mutations in Cu, Zn superoxide dismutase (SOD1) are one cause for the familial form of t

Externí odkaz: https://doaj.org/article/c1757343a5914f43bc8d202626b37c0a

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