Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Xu Yun Zhao"'
Autor:
Bing Han, Zhan-Ming Li, Xu-Yun Zhao, Kai Liang, Yu-Qin Mao, Shi-Long Zhang, Li-Ying Huang, Chao-Yue Kong, Xin Peng, Hui-Ling Chen, Jia-Ting Huang, Zhao-Xia Wu, Jin-Qing Yao, Pei-Ran Cai, Zheng-Yan Zhang, Xu-Min Zhang, Zhu-Jun Yao, Guo-Qiang Chen, Li-Shun Wang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Obesity and related diseases pose a major health risk, yet current anti-obesity drugs inadequately addressing clinical needs. Here we show AA005, an annonaceous acetogenin mimic, resists obesity induced by high-fat diets and leptin mutations
Externí odkaz:
https://doaj.org/article/6fc4b8b8320f4c158db395a138e49514
Publikováno v:
Redox Report, Vol 28, Iss 1 (2023)
ABSTRACTPrimary hepatocytes are widely used as a tool for studying metabolic function and regulation in the liver. However, the metabolic properties of primary hepatocytes are gradually lost after isolation. Here, we illustrated that fatty acid metab
Externí odkaz:
https://doaj.org/article/b344c617d49142f49f7f912b7befd78c
Autor:
Wenkai Zhou, Yisheng Feng, Chengzhong Lin, Chi Kuan CHAO, Ziqi He, Shiyao Zhao, Jieyuan Xue, Xu‐Yun Zhao, Wei Cao
Publikováno v:
Advanced Science, Vol 10, Iss 25, Pp n/a-n/a (2023)
Abstract LncRNAs play a critical role in oral squamous cell carcinoma (OSCC) progression. However, the function and detailed molecular mechanism of most lncRNAs in OSCC are not fully understood. Here, a novel nuclear‐localized lncRNA, DUXAP9 (DUXAP
Externí odkaz:
https://doaj.org/article/5d263ffb68764a90801601186ccde59f
Autor:
Tongyu Liu, Lin Mi, Jing Xiong, Peter Orchard, Qi Yu, Lei Yu, Xu-Yun Zhao, Zhuo-Xian Meng, Stephen C. J. Parker, Jiandie D. Lin, Siming Li
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The regulatory networks that govern chromatin accessibility and gene expression in brown and beigeadipocytes remain to be fully elucidated. Here the authors use fat-specific inactivation of BAF60a toreveal a differential role for this chromatin remod
Externí odkaz:
https://doaj.org/article/9367a3385a00407688e6ae5ad541e1f3
Autor:
Xu-Yun Zhao, Siming Li, Jennifer L. DelProposto, Tongyu Liu, Lin Mi, Cara Porsche, Xiaoling Peng, Carey N. Lumeng, Jiandie D. Lin
Publikováno v:
Molecular Metabolism, Vol 14, Iss , Pp 60-70 (2018)
Objective: Long noncoding RNAs (lncRNAs) are emerging as powerful regulators of adipocyte differentiation and gene expression. However, their significance in adipose tissue metabolism and physiology has not been demonstrated in vivo. We previously id
Externí odkaz:
https://doaj.org/article/f63a544fb87947608e82d4b239babbc8
Autor:
Xu-Yun Zhao, Xuelian Xiong, Tongyu Liu, Lin Mi, Xiaoling Peng, Crystal Rui, Liang Guo, Siming Li, Xiaoying Li, Jiandie D. Lin
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
The LXR-SREBP1c pathway promotes hepatic lipogenesis that is deregualted in fatty liver disease. Here the authors show that the long noncoding RNA Blnc1 contributes to the development of obesity-driven steatosis by enabling SREBP1c trascriptional act
Externí odkaz:
https://doaj.org/article/5cb9c080fd1e4921b29a4d16a40ab672
Autor:
Zhimin Chen, Guo-Xiao Wang, Sara L. Ma, Dae Young Jung, Hyekyung Ha, Tariq Altamimi, Xu-Yun Zhao, Liang Guo, Peng Zhang, Chun-Rui Hu, Ji-Xin Cheng, Gary D. Lopaschuk, Jason K. Kim, Jiandie D. Lin
Publikováno v:
Molecular Metabolism, Vol 6, Iss 8, Pp 863-872 (2017)
Objective: Brown and white adipose tissue exerts pleiotropic effects on systemic energy metabolism in part by releasing endocrine factors. Neuregulin 4 (Nrg4) was recently identified as a brown fat-enriched secreted factor that ameliorates diet-induc
Externí odkaz:
https://doaj.org/article/52f145a393e44c87914693d39c2777e6
Publikováno v:
Molecular Metabolism, Vol 6, Iss 1, Pp 101-110 (2017)
Objective: Long noncoding RNAs (lncRNAs) are emerging as important regulators of diverse biological processes. Recent work has demonstrated that the inducible lncRNA Blnc1 stimulates thermogenic gene expression during brown and beige adipocyte differ
Externí odkaz:
https://doaj.org/article/8a4150840e974414bb3fff46823adcf7
Autor:
Jing Xiong, Peter Orchard, Siming Li, Zhuo Xian Meng, Jiandie D. Lin, Qi Yu, Stephen C. J. Parker, Tongyu Liu, Lei Yu, Lin Mi, Xu-Yun Zhao
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Brown and beige fat share a remarkably similar transcriptional program that supports fuel oxidation and thermogenesis. The chromatin-remodeling machinery that governs genome accessibility and renders adipocytes poised for thermogenic activation remai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ff784fd210e6c78cc869b629e8bfcd6
https://doaj.org/article/9367a3385a00407688e6ae5ad541e1f3
https://doaj.org/article/9367a3385a00407688e6ae5ad541e1f3
Autor:
Jiandie D. Lin, Siming Li, Ling Qi, Yewei Ji, Zhimin Chen, Xu-Yun Zhao, Xiaoling Peng, Linkang Zhou
Publikováno v:
Science Advances. 6
Depletion of fat-resident regulatory T cells (Tregs) and group 2 innate lymphoid cells (ILC2s) has been causally linked to obesity-associated insulin resistance. However, the molecular nature of the pathogenic signals suppress adipose Tregs and ILC2s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1400c3b0cee1af6ce7c5f171df95e28c
https://doi.org/10.1126/sciadv.aay6191
https://doi.org/10.1126/sciadv.aay6191