Recent Advances in Organocatalyzed Asymmetric Reduction of Prochiral Ketones: An Update

Autor: Xu-Long Qin, Li-Jun Xu, Fu-She Han

Publikováno v: Synthesis. 54:1708-1720

Chiral alcohols are important synthetic intermediates and building blocks for the synthesis of drugs, agrochemicals, and natural products. Asymmetric reduction of prochiral ketones has been the most investigated method for accessing chiral alcohols.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed5799a4660f56a4b61a6d4dd0170339
https://doi.org/10.1055/a-1697-7758

Enantioselective Total Synthesis and Absolute Configuration Assignment of (+)-Toxicodenane A

Autor: Xu-Long Qin, Guo-Jie Wu, Fu-She Han

Publikováno v: Organic letters. 23(21)

We present the first enantioselective total synthesis and absolute configuration assignment of (+)-toxicodenane A via a nine-step sequence from the readily available material. The synthesis features a desymmetric enantioselective reduction of 2,2-dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12cca1ceb712541ac3cfdbb46299a8f6
https://pubmed.ncbi.nlm.nih.gov/34652928

Pd-catalyzed enantioselective C–H arylation of phosphinamides with boronic acids for the synthesis of P-stereogenic compounds

Autor: Yuan-Hui Chen, Jing Guan, Fu-She Han, Zhijun Du, Xu-Long Qin

Publikováno v: Tetrahedron: Asymmetry. 28:522-531

A Pd-catalyzed enantioselective C–H arylation of phosphinamides with aryl boronic acids is presented. With readily affordable amino acid derivatives as chiral ligands, the reaction proceeded efficiently to afford the P-stereogenic phosphinamides in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b6e0bdc942bd99555fb410af306a6ec
https://doi.org/10.1016/j.tetasy.2017.03.008

Semisynthesis of Fluoro-substituted Benzoates of Epi-gallocatechin

Autor: Tao Jiang, Xue Min Li, Di Chen, Sheng Biao Wan, Xu Long Qin, Jian Yuan, Q. Ping Dou, Tak Hang Chan

Publikováno v: Synthetic Communications. 42:3524-3531

In the present study, four fluoro-substituted benzoates of epi-gallocatechin (EGC) were prepared through a semisynthetic strategy, and the yield of benzylation of epi-gallocatechin gallate (−)-EGCG was improved by using freshly purified (−)-EGCG

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::83263bad22aaadf669ce870c0edc6c77
https://doi.org/10.1080/00397911.2011.585269

Prodrugs of fluoro-substituted benzoates of EGC as tumor cellular proteasome inhibitors and apoptosis inducers

Autor: Tao Jiang, Di Chen, Zhiyong Yu, Xu Long Qin, Q. Ping Dou, Yan Yan Gu, Qiuzhi Cindy Cui, Sheng Biao Wan

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 9, Iss 6, Pp 951-961 (2008)
Volume 9
Issue 6
Pages 951-961

The most potent catechin in green tea is (-)-epigallocatechin-3-gallate [(-)- EGCG], which, however, is unstable under physiological conditions. To discover more stable and more potent polyphenol proteasome inhibitors, we synthesized several novel fl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4abcf8872682a306c524aa3d14c0c358
https://pubmed.ncbi.nlm.nih.gov/19325839