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pro vyhledávání: '"Xu‐Qiao Chen"'
Autor:
Xu-Qiao Chen
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/8444755e7edb4d559a9d56d99263ffc6
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-20 (2021)
Abstract Background Impaired axonal transport may contribute to the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease (AD) and Down syndrome (DS). Axonal transport is a complex process in which specific motor proteins move c
Externí odkaz:
https://doaj.org/article/b1d6b1a81e6c469a96beb036522311a7
Autor:
Xu-Qiao Chen, Zhuo Xing, Quang-Di Chen, Richard J. Salvi, Xuming Zhang, Benjamin Tycko, William C. Mobley, Y. Eugene Yu
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Down syndrome (DS) is the most common genetic cause of Alzheimer’s disease (AD) due to trisomy for all or part of human chromosome 21 (Hsa21). It is also associated with other phenotypes including distinctive facial features, cardiac defects, growt
Externí odkaz:
https://doaj.org/article/bffcd0fd52544b958fda18942a7a1def
Publikováno v:
Translational Oncology, Vol 12, Iss 3, Pp 475-484 (2019)
Early detection of gastrointestinal tumors improves patient survival. However, patients with these tumors are typically diagnosed at an advanced stage and have poor prognosis. The incidence and mortality of gastrointestinal cancers, including esophag
Externí odkaz:
https://doaj.org/article/7e30f1e818cc4932bd6896e186a94295
Autor:
Zhongying Mo, Xiaobei Zhao, Huaqing Liu, Qinghua Hu, Xu-Qiao Chen, Jessica Pham, Na Wei, Ze Liu, Jiadong Zhou, Robert W. Burgess, Samuel L. Pfaff, C. Thomas Caskey, Chengbiao Wu, Ge Bai, Xiang-Lei Yang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Mutations in glycyl-tRNA synthetase (GlyRS) cause Charcot-Marie-Tooth disease, a neuromuscular disorder characterized by axonal degeneration. Here the authors show that mutant GlyRS interacts with histone deacetylase 6, resulting in increased deacety
Externí odkaz:
https://doaj.org/article/dde98cded6fc4c8db9679bb17adaa174
Autor:
Xu-Qiao Chen
Publikováno v:
Neural Regeneration Research, Vol 14, Iss 4, Pp 588-590 (2019)
Externí odkaz:
https://doaj.org/article/3b2f1d7ba3834c579d0e101cb8ae0110
Autor:
Xu-Qiao Chen, Carlos A. Barrero, Rodrigo Vasquez-Del Carpio, E. Premkumar Reddy, Chiara Fecchio, Salim Merali, Alessia Deglincerti, Cheng Fang, Jack Rogers, Maria L. Maccecchini
Publikováno v:
Pharmaceutics, Vol 13, Iss 12, p 2109 (2021)
Posiphen tartrate (Posiphen) is an orally available small molecule that targets a conserved regulatory element in the mRNAs of amyloid precursor protein (APP) and α-synuclein (αSYN) and inhibits their translation. APP and αSYN can cause neurodegen
Externí odkaz:
https://doaj.org/article/89386ce687ad4c2ebd214da12cad2f41
Autor:
Xu-Qiao Chen
Publikováno v:
Neural Regeneration Research, Vol 16, Iss 12, Pp 2420-2421 (2021)
Externí odkaz:
https://doaj.org/article/3326e8b2372b46eda3f2ca7e07c1e385
Autor:
Xu-Qiao Chen, William C. Mobley
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Alzheimer disease (AD) represents an oncoming epidemic that without an effective treatment promises to exact extraordinary human and financial burdens. Studies of pathogenesis are essential for defining targets for discovering disease-modifying treat
Externí odkaz:
https://doaj.org/article/436b1c4f8f7c4abe8bbd6b54627c65cf
Autor:
Xu-Qiao Chen, William C. Mobley
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Alzheimer disease (AD) represents an oncoming epidemic that without an effective treatment promises to exact extraordinary financial and emotional burdens (Apostolova, 2016). Studies of pathogenesis are essential for defining critical molecular and c
Externí odkaz:
https://doaj.org/article/1a9ec93b963048339732244bcf265554