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CXCL5 impedes CD8 ⁺ T cell immunity by upregulating PD-L1 expression in lung cancer via PXN/AKT signaling phosphorylation and neutrophil chemotaxis.

Autor: Sun D; Department of Thoracic and Cardiac Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China., Tan L; Department of nursing administration, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China., Chen Y; Department of Thoracic and Cardiac Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China., Yuan Q; Department of interventional medicine, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China., Jiang K; Department of Thoracic and Cardiac Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China., Liu Y; Department of Vascular Surgery, Hospital of Zhangjiagang, Suzhou, 215600, China., Xue Y; Department of Thoracic Surgery, Hospital of Yancheng, Yancheng, 224000, China., Zhang J; Department of Thoracic and Cardiac Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China., Cao X; Department of Thoracic and Cardiac Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China., Xu M; Department of Thoracic and Cardiac Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China., Luo Y; Department of Thoracic and Cardiac Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China., Xu Z; Department of Thoracic and Cardiac Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China., Xu Z; Department of Thoracic and Cardiac Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China., Xu W; Department of Thoracic and Cardiac Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China., Shen M; Department of Thoracic and Cardiac Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China. shenmingjing0707@126.com.

Publikováno v: Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2024 Jul 22; Vol. 43 (1), pp. 202. Date of Electronic Publication: 2024 Jul 22.