Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Xizhe Gao"'
Autor:
Xizhe Gao, Yi-Hua Sheng, Sijia Yu, Jiadong Li, Raymond Rosa, Simone Girgis, Tiffany Guo, Luigi Brunetti, Leonid Kagan
Publikováno v:
Pharmaceutical Research.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcc5f03e82ef7a0076056e522d43bf4b
https://doi.org/10.1007/s11095-023-03496-y
https://doi.org/10.1007/s11095-023-03496-y
Publikováno v:
Pharmaceutical research. 39(8)
To evaluate the duration of effect of rHuPH20 on SC absorption of cetuximab and to develop a mechanistic pharmacokinetic model linking the kinetics of rHuPH20 action with hyaluronan (HA) homeostasis and absorption of cetuximab from the SC space.Serum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c5cf35d75a8c0e2871d20bf4a03a279
https://pubmed.ncbi.nlm.nih.gov/35778631
https://pubmed.ncbi.nlm.nih.gov/35778631
Autor:
Xizhe Gao, Gerard Dalglish, Leonid Kagan, Claudia Generaux, Raymond Rosa, Alexander T. Kozhich, Gregory Voronin, Sarah Oh, Anne Rose
Publikováno v:
Pharmaceutical Research. 37
The purpose of this work was to investigate the role of the lymphatic system in the pharmacokinetics of etanercept, a fusion protein. Etanercept 1 mg/kg was administered intravenously (IV) and subcutaneously (SC) to thoracic lymph duct-cannulated and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fed24ae4b0822d749f1bd3e474fda07
https://doi.org/10.1007/s11095-020-02860-6
https://doi.org/10.1007/s11095-020-02860-6
Autor:
William Dall'acqua, Kevin L Allen, Keith W Rickert, Jason White, Kim Rosenthal, Ping Tsui, Norman C. Peterson, Qing Li, Chris Lloyd, Xizhe Gao, M. Jack Borrok, Herren Wu
Publikováno v:
Journal of Controlled Release. 279:126-135
The accumulation, dissemination and clearance of monoclonal antibody-based therapeutics or imaging reagents targeting tumor associated antigens is governed by several factors including affinity, size, charge, and valency. Tumor targeting antibody fra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eeb1e87904ba1ce567ceb02a6d38b11
https://doi.org/10.1016/j.jconrel.2018.04.013
https://doi.org/10.1016/j.jconrel.2018.04.013
Autor:
Robert E. Hollingsworth, Adeela Kamal, Haihong Zhong, Ryan Fleming, Nazzareno Dimasi, Herren Wu, Mary Jane Hinrichs, Xiang-Qing Yu, Pamela Thompson, Robert M. Woods, Patrick Strout, Song Cho, Cui Chen, Molly Reed, Rakesh Dixit, Binyam Bezabeh, Fengying Huang, Jay Harper, Xizhe Gao, Shenlan Mao, Changshou Gao
Publikováno v:
Journal of Controlled Release. 236:100-116
Antibody-drug conjugates (ADCs) are among the most promising empowered biologics for cancer treatment. ADCs are commonly prepared by chemical conjugation of small molecule cytotoxic anti-cancer drugs to antibodies through either lysine side chains or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66c2272903e2d1065a7e37d4befb96bc
https://doi.org/10.1016/j.jconrel.2016.06.025
https://doi.org/10.1016/j.jconrel.2016.06.025
Autor:
William Dall'acqua, Xiang-Qing Yu, Adem C. Koksal, Romana Cvitkovic, C. Kendall Stover, Jessica Bonnell, Yan Chen, Qun Wang, Xizhe Gao, Xiaodong Xiao, Chien-Ying Chang, Ellen O'Connor, Mark Pelletier, Herren Wu
Publikováno v:
mAbs. 9(3)
Antibodies carry out a plethora of functions through their crystallizable fragment (Fc) regions, which can be naturally tuned by the adoption of several isotypes and post-translational modifications. Protein engineering enables further Fc function mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29e7dcf01a0a17831a62580a61398f2a
https://pubmed.ncbi.nlm.nih.gov/28102754
https://pubmed.ncbi.nlm.nih.gov/28102754
Publikováno v:
The Journal of Biological Chemistry
Antibody therapeutics offer effective treatment options for a broad range of diseases. One of the greatest benefits of antibody therapeutics is their extraordinarily long serum half-life, allowing infrequent dosing with long-lasting effects. A charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc1c9c7190c95725f53ba5d6ec9eb1ae
https://pubmed.ncbi.nlm.nih.gov/28258216
https://pubmed.ncbi.nlm.nih.gov/28258216
Publikováno v:
Journal of Pharmacy and Pharmacology. 63:238-244
Objectives Silymarin or silybin has been effectively used for treating liver diseases and acute liver injury partly due to its antioxidant activity. In this study, 2,3-dehydrosilymarin, a compound exhibiting remarkable antiradical/antioxidant activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d934a6c519df68e3d213e12bd5b7cf8e
https://doi.org/10.1111/j.2042-7158.2010.01210.x
https://doi.org/10.1111/j.2042-7158.2010.01210.x
Autor:
Chelsea Black, Joyson Joseph Karakunnel, Bo Zheng, Xizhe Gao, Matthew Joseph Gribbin, Lorin Roskos, Rajesh Narwal, Xuyang Song
Publikováno v:
Cancer Research. 77:5045-5045
Background: MEDI0680 (AMP-514) is a humanized immunoglobulin gamma 4, kappa (IgG4κ) monoclonal antibody (mAb) specific for human programmed cell death-1 (PD-1), developed for the treatment of cancer. The primary objectives of this analysis were to (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::412cafcb0adabd8edecd679cef32123d
https://doi.org/10.1158/1538-7445.am2017-5045
https://doi.org/10.1158/1538-7445.am2017-5045
Autor:
Portnoff, Alyse D.1, Cuihua Gao1, Borrok, M. Jack1, Xizhe Gao2, Changshou Gao1 gaoc@medimmune.com, Rainey, G. Jonah1 jrainey@mabvax.com
Publikováno v:
Journal of Biological Chemistry. 5/19/2017, Vol. 292 Issue 20, p8498-8506. 9p.