Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Xizhe Gao"'
Autor:
Xizhe Gao, Yi-Hua Sheng, Sijia Yu, Jiadong Li, Raymond Rosa, Simone Girgis, Tiffany Guo, Luigi Brunetti, Leonid Kagan
Publikováno v:
Pharmaceutical Research.
Publikováno v:
Pharmaceutical research. 39(8)
To evaluate the duration of effect of rHuPH20 on SC absorption of cetuximab and to develop a mechanistic pharmacokinetic model linking the kinetics of rHuPH20 action with hyaluronan (HA) homeostasis and absorption of cetuximab from the SC space.Serum
Autor:
Xizhe Gao, Gerard Dalglish, Leonid Kagan, Claudia Generaux, Raymond Rosa, Alexander T. Kozhich, Gregory Voronin, Sarah Oh, Anne Rose
Publikováno v:
Pharmaceutical Research. 37
The purpose of this work was to investigate the role of the lymphatic system in the pharmacokinetics of etanercept, a fusion protein. Etanercept 1 mg/kg was administered intravenously (IV) and subcutaneously (SC) to thoracic lymph duct-cannulated and
Autor:
William Dall'acqua, Kevin L Allen, Keith W Rickert, Jason White, Kim Rosenthal, Ping Tsui, Norman C. Peterson, Qing Li, Chris Lloyd, Xizhe Gao, M. Jack Borrok, Herren Wu
Publikováno v:
Journal of Controlled Release. 279:126-135
The accumulation, dissemination and clearance of monoclonal antibody-based therapeutics or imaging reagents targeting tumor associated antigens is governed by several factors including affinity, size, charge, and valency. Tumor targeting antibody fra
Autor:
Robert E. Hollingsworth, Adeela Kamal, Haihong Zhong, Ryan Fleming, Nazzareno Dimasi, Herren Wu, Mary Jane Hinrichs, Xiang-Qing Yu, Pamela Thompson, Robert M. Woods, Patrick Strout, Song Cho, Cui Chen, Molly Reed, Rakesh Dixit, Binyam Bezabeh, Fengying Huang, Jay Harper, Xizhe Gao, Shenlan Mao, Changshou Gao
Publikováno v:
Journal of Controlled Release. 236:100-116
Antibody-drug conjugates (ADCs) are among the most promising empowered biologics for cancer treatment. ADCs are commonly prepared by chemical conjugation of small molecule cytotoxic anti-cancer drugs to antibodies through either lysine side chains or
Autor:
William Dall'acqua, Xiang-Qing Yu, Adem C. Koksal, Romana Cvitkovic, C. Kendall Stover, Jessica Bonnell, Yan Chen, Qun Wang, Xizhe Gao, Xiaodong Xiao, Chien-Ying Chang, Ellen O'Connor, Mark Pelletier, Herren Wu
Publikováno v:
mAbs. 9(3)
Antibodies carry out a plethora of functions through their crystallizable fragment (Fc) regions, which can be naturally tuned by the adoption of several isotypes and post-translational modifications. Protein engineering enables further Fc function mo
Autor:
Chelsea Black, Joyson Joseph Karakunnel, Bo Zheng, Xizhe Gao, Matthew Joseph Gribbin, Lorin Roskos, Rajesh Narwal, Xuyang Song
Publikováno v:
Cancer Research. 77:5045-5045
Background: MEDI0680 (AMP-514) is a humanized immunoglobulin gamma 4, kappa (IgG4κ) monoclonal antibody (mAb) specific for human programmed cell death-1 (PD-1), developed for the treatment of cancer. The primary objectives of this analysis were to (
Publikováno v:
Journal of Pharmacy and Pharmacology. 63:238-244
Objectives Silymarin or silybin has been effectively used for treating liver diseases and acute liver injury partly due to its antioxidant activity. In this study, 2,3-dehydrosilymarin, a compound exhibiting remarkable antiradical/antioxidant activit