Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Xiying, Qu"'
Autor:
Yu Lan, Ping Bai, Zude Chen, Ramesh Neelamegam, Michael S. Placzek, Hao Wang, Stephanie A. Fiedler, Jing Yang, Gengyang Yuan, Xiying Qu, Hayden R. Schmidt, Jinchun Song, Marc D. Normandin, Chongzhao Ran, Changning Wang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 9, Iss 6, Pp 1204-1215 (2019)
The sigma-1 receptor (σ1R) is a unique intracellular protein. σ1R plays a major role in various pathological conditions in the central nervous system (CNS), implicated in several neuropsychiatric disorders. Imaging of σ1R in the brain using positr
Externí odkaz:
https://doaj.org/article/6f8047a7f7314da6b2b69e01ff50ae50
Publikováno v:
Viruses, Vol 14, Iss 3, p 468 (2022)
Human transmission of SARS-CoV-2 and emergent variants of concern continue to occur globally, despite mass vaccination campaigns. Public health strategies to reduce virus spread should therefore rely, in part, on frequent screening with rapid, inexpe
Externí odkaz:
https://doaj.org/article/ff97c534b54b4e35b25147321335ed91
Autor:
Haiyan Ji, Panpan Lu, Baochi Liu, Xiying Qu, Yanan Wang, Zhengtao Jiang, Xinyi Yang, Yangcheng Zhong, He Yang, Hanyu Pan, Lin Zhao, Jianqing Xu, Hongzhou Lu, Huanzhang Zhu
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 12, Iss , Pp 67-74 (2018)
Highly active anti-retroviral therapy (HAART) cannot clear infected cells harboring HIV-1 proviral DNA from HIV-1-infected patients. We previously demonstrated that zinc-finger nucleases (ZFNs) can specifically and efficiently excise HIV-1 proviral D
Externí odkaz:
https://doaj.org/article/3492fa03c2d042ff8838feef759b40c0
Autor:
Georges El Fakhri, Normandin, Nicolas Guehl, Maeva Dhaynaut, Sepideh Afshar, Xiying Qu, Sung-Hyun Moon, Gengyang Yuan, Ramesh Neelamegam, Pekka Poutiainen, Anna-Lissa Brownell
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 43:296-308
Metabotropic glutamate receptor 2 (mGluR2) has been extensively studied for the treatment of various neurological and psychiatric disorders. Understanding of the mGluR2 function is pivotal in supporting the drug discovery targeting mGluR2. Herein, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29ec040acb2504e3c1cd52ea7aaaa40b
https://doi.org/10.1177/0271678x221130387
https://doi.org/10.1177/0271678x221130387
Autor:
Junxiao Deng, Xiying Qu, Panpan Lu, Xinyi Yang, Yuqi Zhu, Haiyan Ji, Yanan Wang, Zhengtao Jiang, Xian Li, Yangcheng Zhong, He Yang, Hanyu Pan, Won-Bin Young, Huanzhang Zhu
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 6, Iss , Pp 233-242 (2017)
HIV-1 inserts its proviral DNA into the infected host cells, by which HIV proviral DNA can then be duplicated along with each cell division. Thus, provirus cannot be eradicated completely by current antiretroviral therapy. We have developed an innova
Externí odkaz:
https://doaj.org/article/8d195c47f1424fe5b8be022e7106d31b
Autor:
Sepideh, Afshar, Sevda, Lule, Gengyang, Yuan, Xiying, Qu, Chuzhi, Pan, Michael, Whalen, Anna-Liisa, Brownell, Maria, Mody
Publikováno v:
Translational Neuroscience. 13:80-92
Fragile X syndrome (FXS) is a monogenic disorder characterized by intellectual disability and behavioral challenges. It is caused by aberrant methylation of the fragile X mental retardation 1 (FMR1) gene. Given the failure of clinical trials in FXS a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9af0978da4491284f608584979df1d4
https://doi.org/10.1515/tnsci-2022-0217
https://doi.org/10.1515/tnsci-2022-0217
Autor:
Hye Jin Kang, Maeva Dhaynaut, Nicolas Guehl, Zhaoda Zhang, Baohui Zheng, Anna-Liisa Brownell, Georges El Fakhri, Sung-Hyun Moon, Gengyang Yuan, Marc D. Normandin, Xiying Qu, Timothy M. Shoup, Sepideh Afshar
Publikováno v:
Molecular Imaging and Biology. 23:527-536
Metabotropic glutamate receptor 2 (mGluR2) has been implicated in various psychiatric and neurological disorders, such as schizophrenia and Alzheimer’s disease. We have previously developed [11C]7 as a PET radioligand for imaging mGluR2. Herein, [1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db2a484c06688829614a4d2051c9f1da
https://doi.org/10.1007/s11307-021-01586-0
https://doi.org/10.1007/s11307-021-01586-0
Autor:
Xiying Qu, Won-Bin Young
Publikováno v:
Journal of Virus Eradication, Vol 2, Iss , Pp 26- (2016)
Externí odkaz:
https://doaj.org/article/f1373727bd7a447eae12095950c7e55c
Autor:
Won-Bin Young, Xiying Qu
Publikováno v:
Journal of Virus Eradication, Vol 2, Iss , Pp 38- (2016)
Externí odkaz:
https://doaj.org/article/9bd5b5c080cc4555a45d9a181cd42d2e
Autor:
Timothy M. Shoup, Chuzhi Pan, Ji-Kyung Choi, Sepideh Afshar, Junfeng Wang, Aijun Zhu, Xiying Qu, Hye Jin Kang, Pekka Poutiainen, Zhaoda Zhang, Anna-Liisa Brownell, Georges El Fakhri, Gengyang Yuan
Publikováno v:
Journal of Medicinal Chemistry. 63:3381-3389
We have synthesized and characterized [18F]-N-(4-chloro-3-((fluoromethyl-d2)thio)phenyl)-picolinamide ([18F]15) as a potential ligand for the positron emission tomography (PET) imaging of mGluR4 in the brain. Radioligand [18F]15 displays central nerv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b66cfdecbcbb01348dc3d7f53268e98d
https://doi.org/10.1021/acs.jmedchem.0c00201
https://doi.org/10.1021/acs.jmedchem.0c00201