Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Xixun, Du"'
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-16 (2024)
Abstract Apolipoprotein D (ApoD), a lipocalin transporter of small hydrophobic molecules, plays an essential role in several neurodegenerative diseases. It was reported that increased immunostaining for ApoD of glial cells surrounding dopaminergic (D
Externí odkaz:
https://doaj.org/article/e8750a93601b41d68e8bb6fa1c7128e5
Autor:
Xue Xiao, Tingting Tang, Mingxia Bi, Jing Liu, Mengru Liu, Qian Jiao, Xi Chen, Chunling Yan, Xixun Du, Hong Jiang
Publikováno v:
Redox Biology, Vol 76, Iss , Pp 103322- (2024)
In Parkinson's disease (PD), exogenous ghrelin protects dopaminergic neurons through its receptor, growth hormone secretagogue receptor (GHSR). However, in contrast to the strikingly low levels of ghrelin, GHSR is highly expressed in the substantia n
Externí odkaz:
https://doaj.org/article/2f44f475dd6342e89790dfdab2a72279
Autor:
Yizhen Liu, Weiwei Wang, Ning Song, Lingling Jiao, Fengju Jia, Xixun Du, Xi Chen, Chunling Yan, Jianwei Jiao, Qian Jiao, Hong Jiang
Publikováno v:
Advanced Science, Vol 9, Iss 30, Pp n/a-n/a (2022)
Abstract Ghrelin contributes to the communication between the brain and gastrointestinal (GI) tract. Both decreased ghrelin levels and functional GI disorders are early events in Parkinson's disease (PD) patients and animal models. However, the reaso
Externí odkaz:
https://doaj.org/article/d09a57f6557d49b4811f2efcbbed4b5e
Publikováno v:
Cell Death and Disease, Vol 12, Iss 2, Pp 1-16 (2021)
Abstract Proteasome is the principal hydrolytic machinery responsible for the great majority of protein degradation. The past three decades have testified prominent advances about proteasome involved in almost every aspect of biological processes. No
Externí odkaz:
https://doaj.org/article/888b3beaf8ab4956a31bd778674bb534
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Abstract Abnormal iron accumulation caused by elevated levels of divalent metal transporter 1 (DMT1) contributes to progressive neurodegeneration in Parkinson's disease (PD). Parkin is a E3 ubiquitin ligase for the ubiquitination of DMT1. S-nitrosyla
Externí odkaz:
https://doaj.org/article/22540776606441e0bc5953c1c4410373
Autor:
Ling Chen, Xuejie Huan, Fengju Jia, Zhen Zhang, Mingxia Bi, Lin Fu, Xixun Du, Xi Chen, Chunling Yan, Qian Jiao, Hong Jiang
Publikováno v:
Antioxidants, Vol 12, Iss 4, p 809 (2023)
OTU domain-containing protein 3 (OTUD3) knockout mice exhibited loss of nigral dopaminergic neurons and Parkinsonian symptoms. However, the underlying mechanisms are largely unknown. In this study, we observed that the inositol-requiring enzyme 1α (
Externí odkaz:
https://doaj.org/article/02827d39b5d9492d858a4d6761db77c8
Publikováno v:
Brain Sciences, Vol 13, Iss 3, p 438 (2023)
Nitric oxide (NO) is a crucial factor in regulating neuronal development. However, certain effects of NO are complex under different physiological conditions. In this study, we used differentiated neural stem cells (NSCs), which contained neural prog
Externí odkaz:
https://doaj.org/article/894bd1d798294127a5add5d38745f257
Autor:
Mingxia Bi, Xixun Du, Xue Xiao, Yingying Dai, Qian Jiao, Xi Chen, Lingqiang Zhang, Hong Jiang
Publikováno v:
Redox Biology, Vol 47, Iss , Pp 102167- (2021)
Aberrant α-synuclein (α-Syn) accumulation resulting from proteasome dysfunction is considered as a prominent factor to initiate and aggravate the neurodegeneration in Parkinson's disease (PD). Although the involvement of 26S proteasome in proteosta
Externí odkaz:
https://doaj.org/article/439bffa1b8c445e6b9d39ba473d8158b
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Iron regulatory protein 2 (IRP2) plays a key role in the cellular iron homeostasis and could be regulated by a variety of factors, such as oxidative stress, hypoxia and iron, etc. IRP2 depletion results in neurodegenerative movement disorder with the
Externí odkaz:
https://doaj.org/article/cf644578bb8c48c8b81aa71f6b72df95
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Parkinson's disease (PD) is characterized not only by typical motor symptoms, but also by nonmotor symptoms in the early stages. In addition to the loss of dopaminergic (DAergic) neurons, progressive degenerations of noradrenergic (NA) and serotonerg
Externí odkaz:
https://doaj.org/article/18351e14a4ef42eea2b2cc799c335231