Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Xixian Chen"'
Publikováno v:
npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract Engineered microorganisms have emerged as viable alternatives for limonene production. However, issues such as low enzyme abundance or activities, and regulatory feedback/forward inhibition may reduce yields. To understand the underlying met
Externí odkaz:
https://doaj.org/article/42937daf53594e4886801272335a0d11
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract Esophageal cancer is a common type of cancer that poses a significant threat to human health. While the pro-inflammatory cytokine IL-1β has been known to contribute to the development of various types of tumors, its role in regulating esoph
Externí odkaz:
https://doaj.org/article/47d12309480c4326a46ebf07a0baa806
Publikováno v:
Engineering Microbiology, Vol 4, Iss 1, Pp 100123- (2024)
The bacterium Escherichia coli (E. coli) is one of the most widely used chassis microbes employed for the biosynthesis of numerous valuable chemical compounds. In the past decade, the metabolic engineering of E. coli has undergone significant advance
Externí odkaz:
https://doaj.org/article/d35ef899241d4444974d0f8bd5c5e1f1
Publikováno v:
PLoS Pathogens, Vol 19, Iss 12, p e1011856 (2023)
The rapid emergence of SARS-CoV-2 variants of concern (VOCs) calls for efforts to study broadly neutralizing antibodies elicited by infection or vaccination so as to inform the development of vaccines and antibody therapeutics with broad protection.
Externí odkaz:
https://doaj.org/article/d8a0dcaf39a54eb194e4f15cf463982f
Autor:
Xixian Chen, Rehka T, Jérémy Esque, Congqiang Zhang, Sudha Shukal, Chin Chin Lim, Leonard Ong, Derek Smith, Isabelle André
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Retrosynthetic pathway design using promiscuous enzymes can provide a solution to the biosynthetic production of natural products. Here, the authors design a pathway for the production of cis-α-irone with a promiscuous methyltransferase using struct
Externí odkaz:
https://doaj.org/article/913a9e6923b0454cb3e5d54b2cd70510
Publikováno v:
Microbial Cell Factories, Vol 21, Iss 1, Pp 1-9 (2022)
Abstract Background α-Ionone is highly valued in cosmetics and perfumery with a global usage of 100–1000 tons per year. Metabolic engineering by microbial fermentation offers a promising way to produce natural (R)-α-ionone in a cost-effective man
Externí odkaz:
https://doaj.org/article/971f45bbdeef46d3887b086cf2aae7fe
Publikováno v:
Engineering Microbiology, Vol 3, Iss 1, Pp 100058- (2023)
Diterpenes, or diterpenoids, are the most abundant and diverse subgroup of terpenoids, the largest family of secondary metabolites. Most diterpenes possess broad biological activities including anti-inflammatory, antiviral, anti-tumoral, antimicrobia
Externí odkaz:
https://doaj.org/article/e162a82eef35416ba05bd65e0236774c
Publikováno v:
Buildings, Vol 13, Iss 9, p 2395 (2023)
Strain measurements have a significant role in evaluating the condition of various structural types and have become an essential component in the area of structural health monitoring. However, there are some limitations in the current means of strain
Externí odkaz:
https://doaj.org/article/73800e33e2864a28b4e3218a65a4074d
Publikováno v:
Microbial Cell Factories, Vol 21, Iss 1, Pp 1-14 (2022)
Abstract Background The recent CRISPR-Cas coupled with λ recombinase mediated genome recombineering has become a common laboratory practice to modify bacterial genomes. It requires supplying a template DNA with homology arms for precise genome editi
Externí odkaz:
https://doaj.org/article/1abfe29a5ccc4b08a11176c17453e68a
Publikováno v:
Bioresources and Bioprocessing, Vol 8, Iss 1, Pp 1-21 (2021)
Abstract In the biosynthesis of natural products, methylation is a common and essential transformation to alter molecules’ bioavailability and bioactivity. The main methylation reaction is performed by S-adenosylmethionine (SAM)-dependent methyltra
Externí odkaz:
https://doaj.org/article/1446aa3d6846450e890070e1a778e4b6