Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Xixi Hou"'
Autor:
Xixi Hou, Longfei Mao, Yajie Guo, Lan Wang, Lizeng Peng, Huili Wang, Jianxue Yang, Sanqiang Li, Yue-Ming Li
Publikováno v:
BMC Chemistry, Vol 18, Iss 1, Pp 1-12 (2024)
Abstract Modification of marketed drugs is an important way to develop drugs because its safety and clinical applicability. Oxygen-nitrogen heterocycles are a class of important active substances discovered in the process of new drug development. Dol
Externí odkaz:
https://doaj.org/article/d66191b3ae3d4647be1e806383cfcfa9
Autor:
En Gao, Ya Wang, Gao-lu Fan, Guiqing Xu, Zi-Yuan Wu, Zi-Jun Liu, Jian-Cheng Liu, Long-Fei Mao, Xixi Hou, Shouhu Li
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract A series of 20 novel gefitinib derivatives incorporating the 1,2,3-triazole moiety were designed and synthesized. The synthesized compounds were evaluated for their potential anticancer activity against EGFR wild-type human non-small cell lu
Externí odkaz:
https://doaj.org/article/f84713dadc2c4faf94fc6075ebdfa619
Publikováno v:
Molecules, Vol 29, Iss 8, p 1779 (2024)
We introduced a terminal alkyne into the core structure of dolutegravir, resulting in the synthesis of 34 novel dolutegravir-1,2,3-triazole compounds through click chemistry. These compounds exhibited remarkable inhibitory activities against two hepa
Externí odkaz:
https://doaj.org/article/6ed4ca75a6ee4c5cbaabc879b27756ad
Autor:
Peng Deng, Xiaodan Dong, Ziyuan Wu, Xixi Hou, Longfei Mao, Jingjing Guo, Wenshan Zhao, Chune Peng, Zhe Zhang, Lizeng Peng
Publikováno v:
Molecules, Vol 29, Iss 8, p 1898 (2024)
In the context of peptide drug development, glycosylation plays a pivotal role. Accordingly, L-type peptides were synthesized predicated upon the PD-1/PD-L1 blocker DPPA-1. Subsequent glycosylation resulted in the production of two distinct glycopept
Externí odkaz:
https://doaj.org/article/2845fef03e4d49e6bbeb75cadc86259d
Autor:
Huaxia Xie, Longfei Mao, Gaolu Fan, Ziyuan Wu, Yimian Wang, Xixi Hou, Jiangang Wang, Huili Wang, Ling Liu, Sanqiang Li
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Based on the structure of the anti-HIV drug cabotegravir, we introduced 1,2,3-triazole groups with different substituents to obtain 19 cabotegravir derivatives and tested their activity against HepG2 cells. The proliferation of HepG2 cells was examin
Externí odkaz:
https://doaj.org/article/5612fbc3d50042a395de40ebf7e890f8
Publikováno v:
Pharmaceuticals, Vol 15, Iss 11, p 1316 (2022)
Indoleamine 2,3-dioxygenase 1 (IDO1) has received much attention as an immunomodulatory enzyme in the field of cancer immunotherapy. While several IDO1 inhibitors have entered clinical trials, there are currently no IDO1 inhibitor drugs on the market
Externí odkaz:
https://doaj.org/article/e9187804be1d4e5cb5dcf60c93927eb3
Publikováno v:
Heterocyclic Communications. 22:291-294
Starting with 4-piperidone, new 5,6,7,8-tetrahydroimidazo[2′,1′:2,3]thiazolo [5,4-c]pyridines were synthesized. Structures of these compounds were confirmed by 1H NMR, 13C NMR, MS and elemental analysis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3747d8ed220d4e8994de4ab15c0b19e2
https://doi.org/10.1515/hc-2016-0137
https://doi.org/10.1515/hc-2016-0137