Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Xiwen Lou"'
Autor:
Senlin Li, Ze Hong, Zhe Wang, Fei Li, Jiahao Mei, Lulu Huang, Xiwen Lou, Simeng Zhao, Lihua Song, Wei Chen, Qiang Wang, Heng Liu, Yanni Cai, Huansha Yu, Huimin Xu, Guangzhi Zeng, Quanyi Wang, Juanjuan Zhu, Xing Liu, Ninghua Tan, Chen Wang
Publikováno v:
Cell Reports, Vol 25, Iss 12, Pp 3405-3421.e7 (2018)
Summary: cGAS-STING signaling is essential for innate immunity. Its misregulation promotes cancer or autoimmune and autoinflammatory diseases, and it is imperative to identify effective lead compounds that specifically downregulate the pathway. We re
Externí odkaz:
https://doaj.org/article/dae1a14407434d41ad9a7d69491e6609
Autor:
Huasong Zeng, Xing Liu, Zengzhang Zheng, Wanyan Deng, Xiwen Lou, Junhong Wang, Yang Bai, Sitang Gong
Publikováno v:
Acta Biochimica et Biophysica Sinica. 52:467-474
Gasdermins (GSDMs) belong to a protein superfamily that is found only in vertebrates and consists of GSDMA, GSDMB, GSDMC, GSDMD, DFNA5 (a.k.a. GSDME) and DFNB59 (a.k.a. Pejvakin (PJVK)) in humans. Except for DFNB59, all members of the GSDM superfamil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d6dcdb88ec339d2af4b0fa0ef1dc94
https://doi.org/10.1093/abbs/gmaa016
https://doi.org/10.1093/abbs/gmaa016
Autor:
Wanyan Deng, Xiwen Lou, Xing Liu, Yi Wang, Rui Miao, Youdong Pan, Shenglin Mei, Rui Min, Zeyu Wu, Pengcheng Chen, Judy Lieberman, Zhibin Zhang, Yang Bai, Wu Li, Zengzhang Zheng, Fan Deng, Tianchi Ma
Publikováno v:
Science
INTRODUCTION An inflammatory innate immune response is a first line of host defense against invading pathogens. Inflammation recruits immune cells to the infection site and activates protective adaptive immune responses. Invasive bacteria have evolve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::273ce107b3676a9cc18374df2a161ae5
https://pubmed.ncbi.nlm.nih.gov/35058659
https://pubmed.ncbi.nlm.nih.gov/35058659
Autor:
Suming Yang, Huijuan Shi, Hongyan Wang, Yifu Ding, Xiwen Lou, Yong Chen, Shuo Huang, Zhanfei Sun, Jinsong Li, Wei Tang, Lei Lu, Meng Yan, Yanjing Li, Qi Yin, Qing Li
Publikováno v:
Nature Cell Biology. 20:1315-1325
CRISPR-mediated base editing can introduce single-nucleotide changes in the DNA of living cells. One intriguing application of base editing is to screen pivotal amino acids for protein function in vivo; however, it has not been achieved. Here, we rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9712ef9cf938f6ba429b0898d19d82c5
https://doi.org/10.1038/s41556-018-0202-4
https://doi.org/10.1038/s41556-018-0202-4
Autor:
Jianbin Ruan, Li Zhao, Hao Wu, Justin Kim, Judy Lieberman, Jun Jacob Hu, L. Robert Hollingsworth, Xing Liu, Shiyu Xia, Hongbo R. Luo, Venkat Giri Magupalli, Yang Bai, Junhong Wang, Zhibin Zhang, Jiangning Zhao, Xiwen Lou, Ying Zhang, Xuemei Luo
Publikováno v:
Nature immunology
Cytosolic sensing of pathogens and damage by myeloid and barrier epithelial cells assembles large complexes called inflammasomes, which activate inflammatory caspases to process cytokines (IL-1β) and gasdermin D (GSDMD). Cleaved GSDMD forms membrane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7cee12ae261c06e82a1cc27a360de43
https://pubmed.ncbi.nlm.nih.gov/32577009
https://pubmed.ncbi.nlm.nih.gov/32577009
Autor:
Jinsong Li, Suming Yang, Wei Tang, Yifu Ding, Hongyan Wang, Meng Yan, Zhanfei Sun, Shuo Huang, Yanjing Li, Yong Chen, Xiwen Lou, Lei Lu, Huijuan Shi, Qi Yin, Qing Li
Publikováno v:
Nature Cell Biology. 21:408-409
In Fig. 2a of this Technical Report originally published, the authors inadvertently used the same set of images for the 4B2N1 and 4B2N3 cells when preparing the figure. The three images (bright field, Oct4-EGFP and pCAG-mRFP) of 4B2N3 cells have now
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e404a16a3fcacd45bc01834568427caf
https://doi.org/10.1038/s41556-018-0265-2
https://doi.org/10.1038/s41556-018-0265-2
Publikováno v:
The Journal of Immunology. 188:358-366
Virus infection induces the MAVS–TNFR-associated factor (TRAF) 3 signaling axis on mitochondria. It remains to elucidate the corresponding regulatory processes. In this study, we identify UXT-V1 as a novel TRAF3-binding protein. UXT-V1 is critical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4e3106d74a0146659383952e618b9fd
https://doi.org/10.4049/jimmunol.1102079
https://doi.org/10.4049/jimmunol.1102079
Autor:
Juanjuan Zhu, Heng Liu, Yanni Cai, Senlin Li, Qiang Wang, Fei Li, Ning-Hua Tan, Zhe Wang, Huimin Xu, Lulu Huang, Chen Wang, Huansha Yu, Xiwen Lou, Quanyi Wang, Guang-Zhi Zeng, Lihua Song, Xing Liu, Jiahao Mei, Wei Chen, Si-Meng Zhao, Ze Hong
Publikováno v:
Cell Reports, Vol 25, Iss 12, Pp 3405-3421.e7 (2018)
Summary: cGAS-STING signaling is essential for innate immunity. Its misregulation promotes cancer or autoimmune and autoinflammatory diseases, and it is imperative to identify effective lead compounds that specifically downregulate the pathway. We re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb0bcebfe29f2295ecec8a2e12b5d58a
https://doi.org/10.1016/j.celrep.2018.11.097
https://doi.org/10.1016/j.celrep.2018.11.097
Autor:
Kai Yang, Chen Wang, Lianhui Zhu, Xiwen Lou, Bianhong Zhang, Shaogang Sun, Hexin Shi, Yujie Tang
Publikováno v:
The Journal of Cell Biology
As a latent transcription factor, nuclear factor kappaB (NF-kappaB) translocates from the cytoplasm into the nucleus upon stimulation and mediates the expression of genes that are important in immunity, inflammation, and development. However, little
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed52cee6383763a2600ba775695e7e71
http://europepmc.org/articles/PMC2064443
http://europepmc.org/articles/PMC2064443
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 186(1)
NF-κB is a family of important transcription factors that modulate immunity, development, inflammation, and cancer. The biological activity of NF-κB is subjected to various spatial and temporal regulations. Bioinformatics analysis predicts that CIT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17472d8e79b2ca6a47e0c9965cffcedd
https://pubmed.ncbi.nlm.nih.gov/21098220
https://pubmed.ncbi.nlm.nih.gov/21098220