Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Xiuxiu Jin"'
Autor:
Xiaoli Zhang, Shun Yao, Lujia Zhang, Beisi Zhang, Mingzhu Yang, Qingge Guo, Jin Xu, Zhongfeng Wang, Bo Lei, Xiuxiu Jin
Publikováno v:
FASEB BioAdvances, Vol 6, Iss 11, Pp 555-564 (2024)
Abstract Mitochondria are vital for retinal cell function and survival, and there is growing evidence linking mitochondrial dysfunction to retinal degenerations. Although ARL3 mutations have been linked to multiple forms of retinal degeneration, the
Externí odkaz:
https://doaj.org/article/8b89c51d5f1143699d937fb8b3c3cfcd
Autor:
Mingzhu Yang, Ruiqi Qiu, Xiuxiu Jin, Shun Yao, Weiping Wang, Jingyang Liu, Guangming Liu, Jinfeng Han, Bo Lei
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Retinitis pigmentosa (RP) is a progressive and degenerative retinal disease resulting in severe vision loss. RP have been extensively studied for pathogenetic mechanisms and treatments. Yet there is little information about alterations of RP
Externí odkaz:
https://doaj.org/article/ae8d4d8f3264411c850837add40663ff
Publikováno v:
Biomedicines, Vol 12, Iss 9, p 2020 (2024)
Increased or altered mitochondrial ROS production in the retinal ganglion cells is regarded as the chief culprit of the disease-causing Leber’s hereditary optic neuropathy (LHON). SkQ1 is a rechargeable mitochondria-targeted antioxidant with high s
Externí odkaz:
https://doaj.org/article/9691a87f163a4d33a24188a613c504f6
Autor:
Xiuxiu Jin, Jingyang Liu, Weiping Wang, Jiangfeng Li, Guangming Liu, Ruiqi Qiu, Mingzhu Yang, Meng Liu, Lin Yang, Xiaofeng Du, Bo Lei
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 20, Iss 4, Pp 633-647 (2022)
Retinal pigment epithelium (RPE) has essential functions, such as nourishing and supporting the neural retina, and is of vital importance in the pathogenesis of age-related retinal degeneration. However, the exact molecular changes of RPE during agin
Externí odkaz:
https://doaj.org/article/66b0b1a7d82c4ffba840d13c19797bb6
Autor:
Lin Yang, Xiuxiu Jin, Ya Li, Qingge Guo, Mingzhu Yang, Ya You, Shun Yao, Xiaoli Zhang, Zhongfeng Wang, Bo Lei
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-10 (2022)
Abstract Dominant optic atrophy (DOA) is the most common hereditary optic neuropathy. Although DOA is caused by mutations in several genes, there are still many cases that have not been diagnosed or misdiagnosed. Herein, we present a large family of
Externí odkaz:
https://doaj.org/article/524bf0d746a9487aa40ef74f5a0eabd5
Autor:
Shun Yao, Qingru Zhou, Mingzhu Yang, Ya Li, Xiuxiu Jin, Qingge Guo, Lin Yang, Fangyuan Qin, Bo Lei
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Heterogeneity is a major feature of Leber's hereditary optic neuropathy (LHON) and has a significant impact on the manifestation and diagnosis of the disease. This study explored whether multiple variations in mitochondrial genes were associated with
Externí odkaz:
https://doaj.org/article/83f95aea19ad472d9879997e80f8fbda
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
PurposeTo study the long-term photoreceptor changes and to evaluate the effects of topical application of a carbonic anhydrase inhibitor (CAI) in a mouse model of X-linked retinoschisis (XLRS).MethodsConventional electroretinograms (ERGs) and dark-ad
Externí odkaz:
https://doaj.org/article/2f2ec0219e1141fdba487a73c238017b
Autor:
Xiuxiu Jin, Li Li, Qinlu Peng, Chunmei Gan, Li Gao, Siyu He, Shuangyan Tan, Wenchen Pu, Yu Liu, Yanqiu Gong, Yuqin Yao, Gang Wang, Xiaohui Liu, Meng Gong, Peng Lei, Huiyuan Zhang, Shiqian Qi, Heng Xu, Hongbo Hu, Biao Dong, Yong Peng, Dan Su, Lunzhi Dai
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104349- (2022)
Summary: Glycyrrhetinic acid (GA) is a natural product of licorice with mitochondria targeting properties and shows broad anticancer activities, but its targets and underlying mechanisms remain elusive. Here, we identified the mitochondrial enzyme se
Externí odkaz:
https://doaj.org/article/76b2f7aeb41a4892af42573508174498
Publikováno v:
Biomolecules, Vol 12, Iss 11, p 1568 (2022)
LHON is a common blinding inherited optic neuropathy caused by mutations in mitochondrial genes. In this study, by using skin fibroblasts derived from LHON patients with the most common m.G11778A mutation and healthy objects, we performed proteomic a
Externí odkaz:
https://doaj.org/article/86fa06d6d41d4f228eac61c09965b442
Autor:
Xiuxiu Jin, Xiaoli Zhang, Jingyang Liu, Weiping Wang, Meng Liu, Lin Yang, Guangming Liu, Ruiqi Qiu, Mingzhu Yang, Shun Yao, Bo Lei
Publikováno v:
Cells, Vol 11, Iss 14, p 2150 (2022)
X-linked retinoschisis (XLRS) is among the most commonly inherited degenerative retinopathies. XLRS is caused by functional impairment of RS1. However, the molecular mechanisms underlying RS1 malfunction remain largely uncharacterized. Here, we perfo
Externí odkaz:
https://doaj.org/article/e525b538c62044dca53402fb064c426e