Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Xiuman Zhou"'
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Background Colorectal cancer (CRC) is the third most prevalent cancer globally, and liver metastasis (CRLM) is the primary cause of death. Hence, it is essential to discover novel prognostic biomarkers and therapeutic drugs for CRLM. Methods
Externí odkaz:
https://doaj.org/article/65b1f28c4cbc4f1c9a0c5c5905e4656b
Publikováno v:
Cancer Biology & Medicine, Vol 21, Iss 3, Pp 198-203 (2024)
Externí odkaz:
https://doaj.org/article/05cd077fced94d669ef2236cc0d7d5a7
Autor:
Shengzhe Jin, Hongfei Wang, Yang Li, Jingwen Yang, Beibei Li, Peishang Shi, Xiangrui Zhang, Xiaowen Zhou, Xiuman Zhou, Xiaoshuang Niu, Menghan Wu, Yahong Wu, Wenjie Zhai, Yuanming Qi, Yanfeng Gao, Wenshan Zhao
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background Targeting the tumor microenvironment (TME) has emerged as a promising strategy in cancer treatment, particularly through the utilization of immune checkpoint blockade (ICB) agents such as PD-1/PD-L1 inhibitors. Despite partial suc
Externí odkaz:
https://doaj.org/article/e691f26caa4b41538892947c9f03fbbd
Autor:
Yuzhen Qian, Yixuan Sun, Peishang Shi, Xiuman Zhou, Qiongqiong Zhang, Qingyu Dong, Shengzhe Jin, Lu Qiu, Xiaoshuang Niu, Xiaowen Zhou, Wenshan Zhao, Yahong Wu, Wenjie Zhai, Yanfeng Gao
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 3, Pp 1150-1165 (2024)
Aside from antibodies, peptides show great potential as immune checkpoint inhibitors (ICIs) due to several advantages, such as better tumor penetration and lower cost. Lymphocyte-activation gene 3 (LAG-3) is an immune checkpoint which can induce T ce
Externí odkaz:
https://doaj.org/article/2ac2caa014eb4e9e8e214552da52bbd8
Autor:
Xiaoshuang Niu, Menghan Wu, Guodong Li, Xiuman Zhou, Wenpeng Cao, Wenjie Zhai, Aijun Wu, Xiaowen Zhou, Shengzhe Jin, Guanyu Chen, Yanying Li, Jiangfeng Du, Yahong Wu, Lu Qiu, Wenshan Zhao, Yanfeng Gao
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 11, Pp 4511-4522 (2023)
Developing new therapeutic agents for cancer immunotherapy is highly demanding due to the low response ratio of PD-1/PD-L1 blockade in cancer patients. Here, we discovered that the novel immune checkpoint VISTA is highly expressed on a variety of tum
Externí odkaz:
https://doaj.org/article/6351c959bc1240cab10ee9ff5e5547e1
Publikováno v:
EJNMMI Research, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Background Accumulating studies have demonstrated that elevated TIGIT expression in tumor microenvironment correlates with better therapeutic response to TIGIT-based immunotherapy in pre-clinical studies. Therefore, a non-invasive method to
Externí odkaz:
https://doaj.org/article/3506dd39748840d5bf66d986bde036fa
Autor:
Xinghua Sui, Chunxia Chen, Xiuman Zhou, Xueyan Wen, Chao Shi, Guanyu Chen, Juan Liu, Zhuoying He, Yongjie Yao, Yin Li, Yanfeng Gao
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-21 (2023)
Abstract Background Esophageal squamous cell carcinoma (ESCC) is a common gastrointestinal malignancy with poor patient prognosis. Current treatment for ESCC, including immunotherapy, is only beneficial for a small subset of patients. Better characte
Externí odkaz:
https://doaj.org/article/c08f8ade765046e48939a7b069ff4352
Autor:
Xiuman Zhou, Chunxia Chen, Guanyu Chen, Wenjie Zhai, Yahong Wu, Yanfeng Gao, Xinghua Sui, Wenhui Shen, Peishang Shi, Qingyu Dong, Wentong Tian, Xueqin Zhu, Xiaoxi Wang, Shengzhe Jin, Lu Qiu
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 6 (2023)
Background Aside from immune checkpoint inhibitors targeting programmed cell death protein 1 (PD-1) and programmed death ligand 1 (PD-L1), intervention of CD47/Sirpα mediated ‘don’t eat me’ signal between macrophage and tumor cell is considere
Externí odkaz:
https://doaj.org/article/bfdb2b1228a14984813b18ec4aaf15ed
Autor:
Yixuan Sun, Yuzhen Qian, Chunxia Chen, Hongfei Wang, Xiuman Zhou, Wenjie Zhai, Lu Qiu, Xiaowen Zhou, Haoming Ning, Yumiao Zhao, Chao Shi, Lu Han, Yuanming Qi, Yahong Wu, Yanfeng Gao
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-22 (2022)
Abstract Background Metastasis is the leading cause of mortality in human cancers, including esophageal squamous cell carcinoma (ESCC). As a pro-inflammatory cytokine, IL-32 was reported to be a poor prognostic factor in many cancers. However, the ro
Externí odkaz:
https://doaj.org/article/46a3f121cd2b45838c425ad29e3bf0dd
Autor:
Yumiao Zhao, Jiaxin Sun, Yin Li, Xiuman Zhou, Wenjie Zhai, Yahong Wu, Guanyu Chen, Shanshan Gou, Xinghua Sui, Wenshan Zhao, Lu Qiu, Yongjie Yao, Yixuan Sun, Chunxia Chen, Yuanming Qi, Yanfeng Gao
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2835-2849 (2021)
Tryptophan 2,3-dioxygnease 2 (TDO2) is specific for metabolizing tryptophan to kynurenine (KYN), which plays a critical role in mediating immune escape of cancer. Although accumulating evidence demonstrates that TDO2 overexpression is implicated in t
Externí odkaz:
https://doaj.org/article/0aa534eb4168403f86ec610c42443d29